snrnp70

U1 small nuclear ribonucleoprotein 70 kDa

471 amino acids

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrnp70 binds to the loop I region of U1-snRNA.

57.204 kDa

MTQFLPPNLLALFAPRDPVPYLPPLDKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQDVENELKIWDPHNDQNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHIVYNKGSEGSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERDRERERDRRERSREREKEPRERRRSRSRERRRKSRSREKEERKRTREKSKDKDKEKDKDNKDRDRKRRSRSRERKRERDRDREKKEERVEAEVPEADDAPQDDAQIGDLGIDGIELKQEPEEKSRERDRERDRDREKGEKDRDKDRDRDRDRRRSHRDRDREKDRDRDRDRRRDRDRDRERDKDHKRERDRGDRSEKREERVPDNGMVMEQAEETSQDMYLDQESMQSGDGYLSTENGYMMEPPME

snrnp70

U1 small nuclear ribonucleoprotein 70 kDa

471 amino acids

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrnp70 binds to the loop I region of U1-snRNA.

57.55 kDa

MTQFLPPNLLALFAPRDPVPYLPPLDKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQDVENELKIWDPHNDQNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYNKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERDRDRERERDRRERSRERDKERERRRSRSRERRRRSRSREKEERKRSRERSRDKDKDKDKDKDKEKDKDKDRDRKRRSRSRERKRERDRDREKKEDRVEGEVPESVDVPQDDAQTGDLGIDGIELKQEPEEKNRDRDRERDREKDRDKDRDRDRDRRRSHRDRERDKDRERDRDRRRDRDRDRDRDRDHKRERDRGDRGEKREERVPDNGMVMEQAEETSQDMYLDQESMQSGDGYLSTENGYMMEPPME

snrnp70

U1 small nuclear ribonucleoprotein 70 kDa

459 amino acids

Mediates the splicing of pre-mRNA by binding to the stem loop I region of U1-snRNA.

53.436 kDa

MAFLPPNLKIMFNPRHPPPFLPPPPPSNLPPYTGLRDYLSIFTDPSNEEPFKKEHIENLEEKREKKRKLKISENDERISKSLKAWDPYSNSETTGDPYKTIFVSRISYKTTQQKLEFEFGQFGPIKSLFLVKDSNNPEKHTGYAFIEFERERDMKAAYKQADGMKIDDRRIVVDIERGRVIKNWKPRKFGGGLGNTRAGGVDVNQTFSGREMSESREKEKEREKEKEKEKERMEKMKKRDGGLSSNGNRSNGISSGSGGSGGDRGDRGDRDRGDRGDRSDRSDRDRERGRGDRDHRGSGGERERERDQRDRGGDRGGDRGDRSDRGRSDRGDRGDRSDRGRDDRERGRDDRGDRGRDDRRGGSDRDRDRGSRDDRGDRDDRSDRGRDDRRGGSDRDHRIDERRRDQRDYGSISDAHFDHFQYQPQQHHHHQQNHQSHHNQPHPERVNRDYSMISNENGF

Snrnp70

U1 small nuclear ribonucleoprotein 70 kDa

448 amino acids

Isoform 2: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

51.992 kDa

MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKDERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGGGGGGSGGGGGGDMAEPSEAGDGAPDDGPPGELGPEGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDREHKRGERGSERGRDEARGGGGSGQDNGLEGLGSDGRDMYMEAEGGDGYMAPENGYLMEAAPE

SNRNP70

U1 small nuclear ribonucleoprotein 70 kDa

439 amino acids

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.

51.426 kDa

MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRDRRRSHRSERERRRDRDRDRDREHKRGERGGDRGRDEARGGGGGGQDNGLEGLGNDGRDMYMESEGGDGYLAPENGYLMEAAPE

SNRNP70

U1 small nuclear ribonucleoprotein 70 kDa

437 amino acids

Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

51.557 kDa

MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE