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SNOG_09421

Gene
SNOG_09421
Protein
Inosine triphosphate pyrophosphatase
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
188 amino acids
Function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
20.737 kDa
Sequence
MSPTPAHLNFITGNKNKLAEVQAILAGVIELRNENIDLVEIQGSVEDVTTDKARRAAEAIKGPVLVEDTCLCFKAMNDLPGPYIKWFMQSLGAAQMHKLLAGFDDKSAQAVCTFAYCEGPGHEPVLFQGRTDGKLVESRGPTAFGWDSCFEYKGQTYAEMDKSEKNKISHRGKALEKLKEWLAQKVDA