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SMU1

Gene
SMU1
Protein
Serine/threonine-protein kinase SMU1
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
746 amino acids
Function
MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity).
Similarity
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Mass
79.535 kDa
Sequence
MSLVPQRSAPPPPSSSANRAASSLAFQPASTSNSASPTSSSTSTFANGSSSSTTAYRPQPTINTSVSALQGPRSGLPAQTGLAFSVSSLSNNPPAASPITAPSSALPWSSQNPAASGSTATFPPRPVRSNTAGPDTLHTISSVSASQTVAPVMVQRSHSSIAAHQASPSLNQSSPTLDADGPASLTTQSHFVHPSRDRERSRDGTTTPGSRNTFKSVFGGFVNSMSDVFSAQKKIEISTPYDPVHLTHVGFNSDTGEFTGLPKEWQQLLQESGISRQDQEANPQAVIDIVAFYQDATQSQGGSDVWKKMGAAKGNKAPATPRTDTSSEDGIYRVAPQPVLYEKPRTAPAPPGITHPNRPSEFGSPDLRQPPSNASTSSADTALRPSRSTPAPGAAPPPNAKTTSSSNPPPCKPSPASRAPDAPAAVSAASKNAKGPGSVPRRRETKKSTIKDSEVIAKLQAICTDADPTKLYRSLQKIGQGASGGVFTAYQVGTNVSVAIKQMNLEQQPKKDLIINEILVMKESRHRNIVNFIDSFLFKGDLWVVMEYMEGGSLTDVVTCNIMTEGQIAAVSREVLEGLRHLHQHGVIHRDIKSDNVLLSLQGDIKLTDFGFCAQIGESQAKRTTMVGTPYWMAPEVVTRKEYGPKVDIWSLGIMCIEMVEGEPPYLNENPLRALYLIATNGTPKINNPENLSNTFKDFLTTSLDVDAERRPDALGMLAHPFLKRSESLRTLTPLIKAAREQTRKS
Protein
Serine/threonine-protein kinase SMU1: SMU1

Gene
smu1
Protein
WD40 repeat-containing protein smu1
Organism
Dictyostelium discoideum
Length
530 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome.
Similarity
Belongs to the WD repeat SMU1 family.
Mass
60.437 kDa
Sequence
MSNPTSTTHHNIEIQSQDVIKLILQFLKENSLGNSLTALQEETGINLNAVDSKETFLNDVKNGNWDSVLTVVSTLRLSTTLLMDLYEQIVELLHLKEYELCKYLIRKTEPLNYMKLNQQERYLKLENHLQREYIDLGDFYKYGITTEKRRKQLIEQLNNEIITVPSSRLLSLLSQSLHWQKHQGIIPDDCMEFDLFKGEVPFKKIESEEEQITTVLDKTIKFNNKNKPETIKFSPDSKYLLTGSMDGFIEVWDYNTGKLSKSLAYQSNDDFMMHDDAILCIAFSKDGEFLATGSLDNKIKVWQIKSGKCLRKFEPAHTNGVTCLQFSRNSTQILSGSFDSSLKIHGLKSGKALKIFRGHQSFVNDCCFNHDEDRVISCSSDGKIKIWDAKSSDCLQTITPTSVVTVRDISIRSITILLKNPEFLLVCNSSQISIVSMKSQTISKTFTSENSKTFLVCTLSPLQNYLYAVDEDNILYTFDFNSGSLLNKFKIHDQEVISISHHPTKNLLATTGSDCLLKIWKSNSNDNINN
Protein
WD40 repeat-containing protein smu1: smu1

Gene
SMU1
Protein
WD40 repeat-containing protein SMU1
Organism
Bos taurus
Length
513 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.544 kDa
Sequence
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: SMU1

Gene
SMU1
Protein
WD40 repeat-containing protein SMU1
Organism
Gallus gallus
Length
513 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.498 kDa
Sequence
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKVWNVKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: SMU1

Gene
SMU1
Protein
WD40 repeat-containing protein SMU1
Organism
Cricetulus griseus
Length
513 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome (Probable). Regulates alternative splicing of the HSPG2 pre-mRNA (PubMed:17105761). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (PubMed:15878348).
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.544 kDa
Sequence
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: SMU1

Gene
smu1
Protein
WD40 repeat-containing protein SMU1
Organism
Danio rerio
Length
513 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Required for normal accumulation of ik (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.531 kDa
Sequence
MSIEIESADVIRLIMQYLKENSLHRTLAMLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQSLKWQQHQGLLPPGMTIDLFRGKAAVKDVEEERFPTQLARHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMSFSRDTEMLATGAQDGKIKVWKIQSGQCLRRYERAHSKGVTCLSFSKDSTQILSASFDQTIRIHGLKSGKCLKEFRGHSSFVNEATLTPDGHHAISASSDGTVKVWNMKTTECTSTFKSLGTSAGTDITVNNVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCTLSPRGEWIYCVGEDYVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIGTYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: smu1

Gene
SMU1
Protein
WD40 repeat-containing protein SMU1
Organism
Homo sapiens
Length
513 amino acids
Function
(Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.544 kDa
Sequence
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: SMU1

Gene
Smu1
Protein
WD40 repeat-containing protein SMU1
Organism
Mus musculus
Length
513 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.544 kDa
Sequence
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: Smu1

Gene
Smu1
Protein
WD40 repeat-containing protein SMU1
Organism
Rattus norvegicus
Length
513 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.551 kDa
Sequence
MSIEIESSDVIRLIMQYLKENSLHRALATFTEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: Smu1

Gene
smu1
Protein
WD40 repeat-containing protein SMU1
Organism
Xenopus laevis
Length
513 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Required for normal accumulation of ik (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.623 kDa
Sequence
MSIEIESSDVIRLIMQYLKENSLHRTLATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQNQSERYIHLENLLARSYFDPREAYPDGSSKEKRRTAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCTLSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIGTYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: smu1

Gene
smu1
Protein
WD40 repeat-containing protein SMU1
Organism
Xenopus tropicalis
Length
513 amino acids
Function
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Required for normal accumulation of ik (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.617 kDa
Sequence
MSIEIESSDVIRLIMQYLKENSLHRTLATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQNQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMIIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDCSQILSASFDQTIRVHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCTLSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIGTYSEDGLLKLWKP
Protein
WD40 repeat-containing protein SMU1: smu1

Gene
SMU1
Protein
Suppressor of mec-8 and unc-52 protein homolog 1
Organism
Arabidopsis thaliana
Length
511 amino acids
Function
Auxiliary spliceosomal protein involved in splicing of specific pre-mRNAs that affect multiple aspects of development. Required for proper accumulation of SMU2.
Similarity
Belongs to the WD repeat SMU1 family.
Mass
57.724 kDa
Sequence
MALEIEARDVIKIMLQFCKENSLNQTFQTLQSECQVSLNTVDSVETFISDINSGRWDSVLPQVSQLKLPRNKLEDLYEQIVLEMIELRELDTARAILRQTQVMGVMKQEQAERYLRMEHLLVRSYFDPHEAYGDSTKERKRAQIAQAVAAEVTVVPPSRLMALIGQALKWQQHQGLLPPGTQFDLFRGTAAMKQDVEDTHPNVLTHTIKFGKKSHAECARFSPDGQFLASSSVDGFIEVWDYISGKLKKDLQYQADESFMMHDDPVLCIDFSRDSEMLASGSQDGKIKIWRIRTGVCIRRFDAHSQGVTSLSFSRDGSQLLSTSFDQTARIHGLKSGKLLKEFRGHTSYVNHAIFTSDGSRIITASSDCTVKVWDSKTTDCLQTFKPPPPLRGTDASVNSIHLFPKNTEHIVVCNKTSSIYIMTLQGQVVKSFSSGNREGGDFVAACVSTKGDWIYCIGEDKKLYCFNYQSGGLEHFMMVHEKDVIGITHHPHRNLLATYSEDCTMKLWKP
Protein
Suppressor of mec-8 and unc-52 protein homolog 1: SMU1