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SMG9

Gene
SMG9
Protein
Protein SMG9
Organism
Bos taurus
Length
520 amino acids
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development.
Similarity
Belongs to the SMG9 family.
Mass
57.638 kDa
Sequence
MSESGHSQPGLYGIERRRRWKEPGPGGPQNLSGPGGRERDYIAPWERERRDGSEETSTAVMQKTPIILSKPPAERSKQPPPPAAPAAPPAPAPLEKPIVLMKPREEGKGPAATTSTSTPEGTAPPPPAAPVPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSEEGAEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLMPFMDSETESETPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA

Gene
SMG9
Protein
Protein SMG9
Organism
Homo sapiens
Length
520 amino acids
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity).
Similarity
Belongs to the SMG9 family.
Mass
57.651 kDa
Sequence
MSESGHSQPGLYGIERRRRWKEPGSGGPQNLSGPGGRERDYIAPWERERRDASEETSTSVMQKTPIILSKPPAERSKQPPPPTAPAAPPAPAPLEKPIVLMKPREEGKGPVAVTGASTPEGTAPPPPAAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDSEAESENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKSSALAEYSRLLA

Gene
Smg9
Protein
Protein SMG9
Organism
Mus musculus
Length
520 amino acids
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development (PubMed:27018474).
Similarity
Belongs to the SMG9 family.
Mass
57.621 kDa
Sequence
MSESGHSQPGLYGIERRRRWKEPGSSGPQNLSGPGGRERDYIAPWERERRDGSEDPSTNVMQKTPIILSKPPAERSKQPPPSTAPAAPPAPAPLEKPIVLMKPREEGKGPVAGTGASTPEGTAPPPPTAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPTAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSAGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDAEVNLFLVPFMDSEAENENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA

Gene
Smg9
Protein
Protein SMG9
Organism
Rattus norvegicus
Length
520 amino acids
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development.
Similarity
Belongs to the SMG9 family.
Mass
57.633 kDa
Sequence
MSESGHSQPGLYGIERRRRWKEPGSSGPQNLSGPGGRERDYIAPWERERRDGSEDPSTNVMQKTPIILSKPPAERSKQPPPSTAPAAPPAPAPLEKPIVLMKPREEGKGPVAATGASTPEGTAPPPPTAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPTAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSAAGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNIFPGLPPDFLDAEVNLFLVPFMDSEAENENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA

Gene
smg9
Protein
Protein SMG9
Organism
Xenopus laevis
Length
508 amino acids
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between smg1 and smg8 (By similarity).
Similarity
Belongs to the SMG9 family.
Mass
56.599 kDa
Sequence
MSDSGHSQPNVFIPGRNRRRRWMDQGPAGNLNLSEPGREKDSVLRDRDQERWEGNDEGCGYTIQKTPIILAKPASDRAKAATPAAPAPIEKPIVLMKAREEGKPTAPAEGAAVPPAAAVAKVEKEGQRPTQPVYQIQNRGMGAAASAGGSVDPVVGQAKLLPPQKMKHSIKLVDEYMNWCDSAIEFLLDQTDVLVVGVLGLQGTGKSTLMSLLSANSPDDDQRSYVFRMQSQEVRERAGNQTSGIDFFISQERIIFLDTQPILSPAILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDFNLYRFLQTAEMLKPSTPSPSHESSGSSGSDEGIEYYPHIVFVQNKSKREDFCPRTLKQMHTVMDKLMLHSHLRYKGTLSMLDCNIFPGLPYDFVESEVNLFLIPTMESDADETISRAGTSGIPLFSLLPAYKGHPSFHSLVSRLRSQIMSMSRPQLSHTILTEKNWFHYAARIWDGVKKSSALSEYSRLLG

Gene
smg9
Protein
Protein SMG9
Organism
Xenopus tropicalis
Length
508 amino acids
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between smg1 and smg8 (By similarity).
Similarity
Belongs to the SMG9 family.
Mass
56.964 kDa
Sequence
MSDSGHSQPNVFIPGRNRRRRWMDQGPPGHLNLSEPGREKDPMLRDRDQDRWEGNEEGYGYTIQKTPIILAKPTSDRTKAATPAAPPPMEKPIVLMKAREDGKPAAPAEGATAPPPTAVAKVEKEGQRPTQPVYQIQNRGMGAAASASGNVDPVVGQAKLLPPQKMKHSIKLVDEYMNWCDSAIEFLLDQTDVLVVGILGLQGTGKSTLMSLLSANSPDDDQRSYVFRMQSQEVRERAGNQTSGIDFFISQERIIFLDTQPILSPAILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDFNLYRFLQTAEMLKPSTPSPSHESSGSSGSDEGIEYYPHVVFVQNKAKREDYCPRTLKQMHTVIDKLMLHSHLRYKGTLSMLDCNIFPGLPYDFIESEVNLFLIPTMESDVDETISRAGTSGIPLFSLLPAYKGHPSFHSLISRLRSQIMSMSRPQLSHTILTEKNWFHYAARIWDGVKKSSALSEYSRLLG

Gene
smg9
Protein
Protein SMG9
Organism
Salmo salar
Length
505 amino acids
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between smg1 and smg8 (By similarity).
Similarity
Belongs to the SMG9 family.
Mass
56.289 kDa
Sequence
MSESGHSQPGMYGQGRRRRRRRDRDVGPPGQNLSGPSRDREYVPRERRDGSEEPPGPLLQKTPIILAKPPGERSKPSQSVPIGGGQALEKPIMLIKSREDGGKPGTPPEVASPCSGASKLEREGQRPTQPVYQIQNRGMGAAASSGAVDPVIGQTKLVPPEKMKHSIKLVDDQMNWCDSAMEYLRDQTDMLVVGVIGLQGTGKSTIMSLLSANAPEEDQRGYVFRAQTQEIKERGGNQSTGIDFYITQERVIFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQITAFLFTVCHVVIVIQDWFTDINLYRFLQTAEMLKPSTPSASHDSTGSSGNEEGSEYYPHIVFLQNKSSRDEFCPRNLKKMHMAVDKLMAHSHLKYKGTLSMLDCNIFPGLDRDYLETEVNMFLLPLMENEGEDALTKAGSGSAPLFSLLPGYRGHPTFSSQVSKLRSQILAMSRCQLSHTILTEKNWFHYAARIWDGVKKSSALSEYSRLQA