SLN

Gene

SLN

Protein

Sarcolipin

Organism

Homo sapiens

Length

31 amino acids

Function

Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity).

Similarity

Belongs to the sarcolipin family.

Mass

3.762 kDa

Sequence

MGINTRELFLNFTIVLITVILMWLLVRSYQY

Gene

Sln

Protein

Sarcolipin

Organism

Mus musculus

Length

31 amino acids

Function

Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle (PubMed:21697544, PubMed:26816378). Required for muscle-based, non-shivering thermogenesis (PubMed:22961106).

Similarity

Belongs to the sarcolipin family.

Mass

3.808 kDa

Sequence

MERSTQELFINFTVVLITVLLMWLLVRSYQY

Gene

SLN

Protein

Sarcolipin

Organism

Oryctolagus cuniculus

Length

31 amino acids

Function

Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle (PubMed:23362265, PubMed:9575189). Required for muscle-based, non-shivering thermogenesis (By similarity).

Similarity

Belongs to the sarcolipin family.

Mass

3.774 kDa

Sequence

MERSTRELCLNFTVVLITVILIWLLVRSYQY

Gene

Sln

Protein

Sarcolipin

Organism

Rattus norvegicus

Length

31 amino acids

Function

Similarity

Belongs to the sarcolipin family.

Mass

3.808 kDa

Sequence

MERSTQELFINFTVVLITVLLMWLLVRSYQY