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SLC6A19

Gene
SLC6A19
Protein
Sodium-dependent neutral amino acid transporter B(0)AT1
Organism
Homo sapiens
Length
634 amino acids
Function
Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:19185582, PubMed:18484095, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:15286788, PubMed:19185582). Required CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582).
Similarity
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.
Mass
71.11 kDa
Sequence
MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY

Gene
Slc6a19
Protein
Sodium-dependent neutral amino acid transporter B(0)AT1
Organism
Mus musculus
Length
634 amino acids
Function
Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:17167413, PubMed:26240152, PubMed:19185582, PubMed:15044460). Required CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582, PubMed:17167413). This uptake is sodium-dependent and chloride-independent (PubMed:15044460, PubMed:18424768, PubMed:19185582, PubMed:21636576, PubMed:26240152).
Similarity
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.
Mass
71.367 kDa
Sequence
MVRLVLPNPGLEERIPSLDELEVIEKEEAGSRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLYLEFAIGQRLRKGSMGVWSSIHPALKGIGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQEPLPWSECPLNQNQTGYVEECAKSSSVDYFWYRETLNISTSISDSGSIQWWILLCLTCAWSVLYVCIIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNITELSNPNTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSVINGFTSVYAATVVYSIIGFRATERFDDCVNTNILTLINGFDLPEGNVTSENFEAYQQWCNATNPQAYAQLKFQTCDINSFLSEGVEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITPKKWPKELLTGLICLGTYLIAFIFTLNSGQYWLSLLDSFAGSIPLLIIAFCEMFAVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKTLMYSIWDPNYEEFPKSQKIPYPNWVYAVVVTVAGVPCLSIPCFAIYKFIRNCCQKSDDHHGLVNTLSTASVNGDLKN

Gene
SLC6A19
Protein
Sodium-dependent neutral amino acid transporter B(0)AT1
Organism
Pongo abelii
Length
634 amino acids
Function
Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. Required CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity. This uptake is sodium-dependent and chloride-independent. In a Xenopus oocyte assay, the substrate preference is the following: Leu > Gln > Phe = Ala > His = Trp >> Glu = Arg.
Similarity
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.
Mass
71.102 kDa
Sequence
MVRLVLPNPGLDTRILSLAELETIEQEEASSRPKWDNKAQYLLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLHLEFAIGQRLRRGSLGVWSSIHPALKGVGLTSMLVSFVVGLYYNTIISWIMWYLFNSFQEPLPWSECPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWRMLLCLACAWSVLYMCTIRGIETTGKVVYITSTLPYVVLTIFLIRGLTLKGATKGIIYLFTPNVTELANPVTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCERDSVIVSIINGFTSVYVAIVIYSIIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVEMQRQCNASNPAAYAQLVFQTCDINSFLSEGVEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLKVIPPKWPKELLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAVSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIILVFFFVVQVSQELTYSIWNPGYEEFPKSQKISHPNWVYAVVVIVAGVPSLTIPSYAIYKLIRNCCQKPGDRQGLVSTLSTASMNGDLKY

Gene
Slc6a19
Protein
Sodium-dependent neutral amino acid transporter B(0)AT1
Organism
Rattus norvegicus
Length
634 amino acids
Function
Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. Required CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity. This uptake is sodium-dependent and chloride-independent.
Similarity
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.
Mass
71.232 kDa
Sequence
MVRLVLPNPGLEDRIPSLDELEVIEKEEASSRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLHLEFAIGQRLRKGSVGVWSSIHPALKGVGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQEPLPWSECPLNQNQTGYVEECAKSSSVDYFWYRETLNISTSISDSGSIQWWILLCLTCAWSVLYVCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNITELSNPNTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSIINGFTSVYAATVVYSIIGFRATERFDDCVNTNILTLINGFDLPEGNVTAENFEAYQHWCNATNPEAYAQLTFQTCDINTFLSEGVEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITPKKWPKELLTGLICLGTYLIAFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFAVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKQLMYSVWDPDYEEFPKSQKVPYPDWVYAVVVIVAGVPCLTIPCFAIYKLIRNYCQKSGDQHGLVNALSTASVNGDLKN