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SLC22A16

Gene
Slc22a16
Protein
Solute carrier family 22 member 16
Organism
Mus musculus
Length
649 amino acids
Function
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent (By similarity).
Similarity
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Mass
73.933 kDa
Sequence
MESCNVELIFDHIGHFGRFQIVLYLICAYQSLSCGIHYLSSVFLSIIPEHACKPPGMVRKAVFHNVSAWRLEDILALRSPEHKDHIMVELQDGEIWELTRCSRTWRENTSHLGYEYSGYKHDSPCFDGYVYDQSKWRNSAVRNFNLVCDQKWYARMIQPLIIFGVMLGSITFSYLSDRFGRRMALWCTSIGVFFFGIASLFIFDYLSFMITRFFLVMASSGYFVVVFVYVMEIIGKKARTWASIHLNTFFAIGAMLVALASYLLKTWWLYQIILCIVTTPFILCCWMLPETPFWLLSEGRYKEAQGTVDTMAVWNKSSSCDLVELLSLDVTRSHNKSPHSIRKHRLADLFHNLDVAKMTLIVWLDWFTANLGYYMFGKEVIRRKENEPLYLLLVGAMEIPAYICLCIWLKRVGRRKTMLLFLLVSSLTCMLHVVMPSDYKTAKRMVALLVKSVISSVFAFIYLYTAELYPTTVRCLAVGSSNMVSHVSSIFIPFTSHFSKVWIFLPQILFGILAILSGLLSLKLPETQDTPMKSTWETTEQQVPENKDSLGEGPPDSFERWDSSRALSFAERWGLSRASPDAEKWGSGRVPPDAGKWGAGIAPPVTERGASGRASLEDESGGSGRAPPEKNTEMENEIENMKVSNLGGF

Gene
SLC22A16
Protein
Solute carrier family 22 member 16
Organism
Homo sapiens
Length
577 amino acids
Function
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.
Similarity
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Mass
64.614 kDa
Sequence
MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE

Gene
SLC22A16
Protein
Solute carrier family 22 member 16
Organism
Bos taurus
Length
572 amino acids
Function
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent (By similarity).
Similarity
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Mass
64.355 kDa
Sequence
MGSSNLELIFDSVGHFGRYQIFLYFICAFQNISCGIHYLASVFLSVSPQHTCRPPGNVSQVLFQDLSTWQLEDIWTQFSVGREDRILVQLQDGAIWELTSCQRFRRDDQSSLDYEYSGQKSSFPCLDGYIYDRSKWLSTVVTQWDLVCNREWFGRLIQPTFMFGVLLGAVIFGYLSDRAGRRLVLWASSTGVFLFGIAAAFTFDYYSFIVARFLLAISGSGYLVVVFVYVTEFVGMKSRTWASIHLHSFFAFGTMVVALTGYFVRTWWIYQIVLSSVTVPFVLCCWMLPETPFWLISGGKYEEAQKVIDTMAKWNRTRPCKLSEILSLDHDGSAGNKPSQVEKHTLSELFYDWSIGTRTLILWLIWFTGCLGFYTFSLNSVHLGGSEYLNLFLMGVVEIPAYVLVCLGMDRVGRRNILIFSLLSSAVTSGVIMVIPKDYHVWLVVASMAGKFFIGAAFGLIYLYTAELYPTIVRSLAVGSGSTVGRVGSIVAPLCIYLSSVWIFMPQLLVGTLALVSGVLTFLLPETLRRPLTTTWEETEKESSSGKLLSTTSNTVLENVTVENSEDSSLNK

Gene
slc22a16
Protein
Solute carrier family 22 member 16
Organism
Xenopus laevis
Length
566 amino acids
Function
High affinity carnitine transporter.
Similarity
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Mass
63.754 kDa
Sequence
MEHLFDYVGHFGRFQAYLYFASAFQTISCGIHYLASVFIAVTPKFICRAPGNISTVLLPNASTLRLEDAWESWTSKDYLVVQQENGDIWELNQCSRLKREDASYLTYFYDGNKTLFSCSNGYHYDKSNLESSIVTEWDLVCDREWLAKLIQPIFMLGVLIGAVIFGDIADRVGRRPIIWITSTGQFLFGIAVAFTFDYYSFVIVRFLLAMVSSGYYVVVFVYLTEYVGIKARTWASMHVHAFFAVGVMIVSLVGFLVRTWWIYQIILSLTTLPFVLCCWMLPETPFWLYSQGKYKEVEKLIRTIEKWNKISTPCKLSELCPAQETHVDQPNTLKNHNVLDLFYNWSFARRTITVWLIWFTGSLGYYVFALNSVNLGGNEYLNLFLTGAVEIPSYIVACLGMDKIGRRNTLAPFLIISAVICGVIMLIPQDHSTVTIAMSMAGKFSIAVAFGLIYLYTAELYPTIVRSLAVGSGSMMCRIGSVVAPFCVYLTDVWIFMPQMLVGIMAFLTGILTLTLPETLGIPLTSTMEEAAEMGTTSGITKRKALTESNGVVMEKLDQTTDNAAS