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SKA3

Gene
ska3
Protein
Spindle and kinetochore-associated protein 3
Organism
Xenopus tropicalis
Length
561 amino acids
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SKA3 family.
Mass
62.908 kDa
Sequence
MSVTGNFFSKLRSLAVTLEKETGQLEQLFSSEDNEYEEESPMRVLHDLRSDIMVLKGDFQSTLNKRLARGQELSAFIKACRVLHERTAADIEQIKETFQTYGYKPQCNANSEREQTQESGKPKENGVSPNKADVEDLQALPTLEKTASTSWDILRAPQLSDFGLAHYQLPTAWEPPKVKPCKKDPEEEKPRIMLKDPEPMNVAKTPKCALRLEEDFSQIQHFGISDCSTNLNDDYTMALINKKFQKNQNVTENAAKETCQPKNLKSLLATPSHLSHRMDWVDSPLPPVFCTPGLKVHKKEKMSLPGKPAEKKGLNANNTTLPSDTCDRNDPDSAHLEDDYECTAVKPAIDFKSTSAAPAYLSLGSNINSVYSPRPPVFCTPGLKVHKKETSSVLADPTEPKGTGCTDTPPLPSFQTNWLKSDAKEKGLDITEPVPRPDLSYRQCLEEPPTLVLNSNKYEAPAMRDYCMGTPPRPEMTVSLTEDLFKYNVKPSSPPKVSEYENMLWTPVRPEMTSCITEDISQILSKYCDNNMNPADGIWDKAGAPFGKISTEYENKENRLY

Gene
ska3
Protein
Spindle and kinetochore-associated protein 3
Organism
Xenopus laevis
Length
556 amino acids
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SKA3 family.
Mass
62.718 kDa
Sequence
MSVTGNFFSKLRSLALTLEKETAQLEQVFGNEDNEYEEESPMRVLHDLRSDIMVLKGDFQSTLDKKLTRGQELSAFIKACRVLHERSAADIEQIKETFQTYGYKPLCNDNSENEQTQESEKPKDNDVSPRKADAEDLPILEKAASTSWDLLRAPQLSDFGLSHYQLPTAWEPPKVKPCPKNPEEEKPRIMYKDPEPINVAKTPKCALRLEEDFSQIQHFGISDCSTNLNDDYTIALINKNFQKKQNDTENETCQAKNLKSLLATPSHLSHRMDCVDSPLPPVFFTPGLKVHKKETISLPGKTGERQGLNAADTDSTLLSGTCDRKDSDNAHLEDVHECTAMKPAMDLKSISAAPPYLSLGSNFDSVYSPRPPVFCTPGLKTHKKETSSVLVEPKEVTGCSDTPPLPSFQTNWLKNDTTEKALDITEPVPRPELSYRQYLEEPPSLVLNSNKYEAPAMTEYDIGTPTRPEMTVSLTEDLFKYNVKPSSPPKMSEYEKMLWTPIRPEMTSCITEDISQILSKYCDNNTNVADKEMWNKAGASFGKISSEYEDKENRQY

Gene
ska3
Protein
Spindle and kinetochore-associated protein 3
Organism
Danio rerio
Length
495 amino acids
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SKA3 family.
Mass
55.834 kDa
Sequence
MNPSERFFSKLRKLTVYLETESSSLLHTSQNLKEDEEDEETGAQALYQLHSEVRALKRQVRDQVATHDTSSADLRSFIRRCLVLKQRTTEDIDSLKKHYEKYGYRPRISRLGSTEVNCTKEAEERAERDAEKLDAAEEDEETERGDCDKVDQSVTPEKMPPPVDQLQTPKLSDFGLSALQFQRVLGEAEVPLSAAPESAIALSSPPILMNLQPPQPKTPKCSLSMEEDALTPRLEDFGISEYTMCWNNDFTMDLFNKKPPKNRSERNENVLKPHNVFSNTSSVLNKDVANKSLESPEPPEFCTPGFKIAKNHVPSTPLFNGKNDLNSPPRLNNNCPSTPELPAFETPFVSKLIKKEDREEESKIHSESQENSLRLPDLSTTNGTSWNDAPEMPKMLRYEEEALPEMPILQSNFGSSLAFKNTSGESLSRMKTGAGHMLEMKQTSVPVPEDGFNQDWCLSTPKVRVKFPAEPCTPEMPDMSSVTQDILKLVAQCKY

Gene
Ska3
Protein
Spindle and kinetochore-associated protein 3
Organism
Rattus norvegicus
Length
419 amino acids
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SKA3 family.
Mass
46.352 kDa
Sequence
MNPIQSFHCKLRSLATVLDGETARLLRALDGEDSEDFEDSSARILCDLYSEVQTLKDDVNAHLDKARLESRESTHFIKAAKVLMKKNSADIIKLREFFQKYGYQARDKEDSACEHRVSNSSPGLAVCKDTQEPGVKQELSEPRVPRGSAPEEPLRSPQLSDFGLQRYMVSQGPANPRQETVSLKEDRASETTPAKDPSVQVLKTPRCALKMDDFECVTPKLEHFGISEYTMCLNEDYTMGLKNMKSIKSSPLSGVGGEAVETGPVTSDNSFAIPGPMIQQLEKNDVEYINSPLPPKFCTPGLKIPSSMDSTDLVSIDYPLSKPNSSPTDLEDKDCAPLILNSDECYQSFADPHSPTITSYENFTTPSPPKVTAIPEDILQMLKYNSNLASPIDVKAMPLRRGFTSKGQSTRGAANKENW

Gene
SKA3
Protein
Spindle and kinetochore-associated protein 3
Organism
Homo sapiens
Length
412 amino acids
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).
Similarity
Belongs to the SKA3 family.
Mass
46.359 kDa
Sequence
MDPIRSFCGKLRSLASTLDCETARLQRALDGEESDFEDYPMRILYDLHSEVQTLKDDVNILLDKARLENQEGIDFIKATKVLMEKNSMDIMKIREYFQKYGYSPRVKKNSVHEQEAINSDPELSNCENFQKTDVKDDLSDPPVASSCISEKSPRSPQLSDFGLERYIVSQVLPNPPQAVNNYKEEPVIVTPPTKQSLVKVLKTPKCALKMDDFECVTPKLEHFGISEYTMCLNEDYTMGLKNARNNKSEEAIDTESRLNDNVFATPSPIIQQLEKSDAEYTNSPLVPTFCTPGLKIPSTKNSIALVSTNYPLSKTNSSSNDLEVEDRTSLVLNSDTCFENLTDPSSPTISSYENLLRTPTPPEVTKIPEDILQLLSKYNSNLATPIAIKAVPPSKRFLKHGQNIRDVSNKEN

Gene
Ska3
Protein
Spindle and kinetochore-associated protein 3
Organism
Mus musculus
Length
411 amino acids
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SKA3 family.
Mass
45.37 kDa
Sequence
MNPIQSFHCKLRGLATTLDSETARLLRALDGEDSDFEDSPGRILHDLHSEVQTLKDNVNALLDEARLENQESTRFKKATKILMEKNSADVRKLREFFQKYGYQARDKEDSGCEHRVNNSTPELAVCKDIQKAGVKELSDPCVPSGSVSEEPLRSPQLSDFGLQRYIISQVPANPPQTAASLKEERVAETPPAKDPSVQVLKTPRCALRMDDFECETPKLEHFGISEHTMCLNEDYTMGLKNMKNIKSSLLSGVSGEAIGTGPVTSDNSFAIPGPIIQQMEENDVEYVSSPLPPKFCTPGLKIPSTMDRTDLVSIDYPLSKPNSSSTDLEIKDCVPLILNSDECYQSFAEPPSSAITSCENFATPSPPKVTAIPEDILQMITKHSSNLASPLDVKVMPRRKGTRGAANKENW

Gene
SKA3
Protein
Spindle and kinetochore-associated protein 3
Organism
Bos taurus
Length
403 amino acids
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SKA3 family.
Mass
44.762 kDa
Sequence
MDPIRGFCGKLRSLAVTLDSETARLQRALDGEDSDFEDCPMRVLHDLNSEVRILKDDVNILLDKANLESQENIGFIKATKILMRKNSMDIMKIKEFFQKYGYTPRAKKNSVDEQEVTDSKPESSECERPEKPDLKDDLLDSAAASTSVSEKSPRSPQLSDFGLERYIVSQVLPNPPQAVNNQKEEPKILTPFSKHSLLKTPKCALKMDDFECVTPKLEHFGISEYTMCLNDDYTIGLKNVKTNSETIETEPVPNDNVFATPGLITQPLGKNNAEHTHSPLAPTFCTPGLKVPSTKTSTAMVSTNSSSNDLETKESTSLVSNSDECFENFADPSSPTISSYENLLKTPTPPEVTTIPEDIRQILSKYNSNLASPVAVRAVSPINVFLPRHGGQNMRDASNKENW