SIGIRR

Single Ig IL-1-related receptor

410 amino acids

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Belongs to the interleukin-1 receptor family.

45.679 kDa

MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDPMLILRGRVPEGRALDSEVDPDPEGDLGVRGPVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM

Sigirr

Single Ig IL-1-related receptor

409 amino acids

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).

Belongs to the interleukin-1 receptor family.

46.159 kDa

MAGVCDMAPNFLSPSEDQALGLALGREVALNCTAWVFSRPQCPQPSVQWLKDGLALGNGSHFSLHEDFWVSANFSEIVSSVLVLNLTNAEDYGTFTCSVWNVSSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVKCRLNMLLWYQDTYGEVEMNDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLVLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRGMESELDPDPEGDLGVRGPVFGEPPTPLQETRICIGESHGSEMDVSDLGSRNYSARTDFYCLVSEDDV

Sigirr

Single Ig IL-1-related receptor

409 amino acids

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).

Belongs to the interleukin-1 receptor family.

46.171 kDa

MAGVCDRVPNFLSPSEDQALGPALGSAVALNCTAWVFSRPQCPQPSVQWLKDGLALGNGSHFSLHQDFWVSDNFSEIVSSVLVFNLTKAEDYGTFTCSAWNVSSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVKCRLNVLLWYQDTYGEVEMNDGKLYDAYVSYSDRPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLRRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLLLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRAMESELDPDPEGDLGVRGPVFGEPPTPLHESKVSIGEGHASEMDVSDLGSRNYSARTDFYCLVSEDDV