SHOC1

Protein SHORTAGE IN CHIASMATA 1

1594 amino acids

Essential for the formation of class I meiotic crossovers.

Belongs to the XPF family.

179.455 kDa

MRTRFLNIDYFSTPPSHVFETLGFLNLPAPDNFPAPIVYNGEEDRLRFGSIENVSIPIGNLPIEAALSKFLSDVVPDRVSVDYRVFEIDDSSLGVYYSDEKDDGDAIADKATPKIIELETPELDFEMENKLLCTSEDHLQCFSEVLEIKNDPVKYEGSDIILQNSKDIQEQIYSVDYIPSDYFTENNTSVAENECFRKIQPWFKDARFPLLEVDEVNLSELSSLSVLDKVFTVLETIEPQDTNAGSSLIINSKELIGSKDYDLLDVLSTDCYLNKSGQSDVVPEDEFSEMDIVTILEISNAEEFQGKVAVPVTYEEFQILDVDISDVFDIFLCLQKAIEPEICYGMFSKEMNFKDFDELVVSSELAFTDDAFKSLPTPILHDYEMTRSLELIYEDVLSKIKPQSLSASNDIYLPWNLLEERNHNHCDYPFEEIVTFNIDYNWEASEGDKWVYDFIFSEDAFCEPLVEKCTEPFYGISNLDEHAPVNTSHGLLENPFQKTGARDCAVDDNAKKATLLFKSMSAFDDLTFFMDPKKAVIEDNLESRVEAAKTTNHKCMSIDSKASCRSGGMHPNPKTEEMILHSVRPSENIQALVGEFVKSYLTLVKDESENLSEDKLKLLSISKGKLIDCIRKANVHKTQLADDKTFTFALLLAIKQMTWYMCFFGIHVAYIYLNKVCRSSNPMKIGLHTLYSAVETEHKSDETDITRSHPSLAVIQGILQSEFARGNSKALLLAEKVFWSSLKRLLMSMGLSYNDLNSPSPSGNRPNVHEAIELGFLPISDCLIISYEQISPSFPVENFSVIVEYGGPNASPRYSFPSKLDSFPSFHFIKVELDMPSACGQLCAGVTVPYSLKMIKGDEVETKTGWLEEVLNFVPLEKVCYAGSSETTNESEFISMPQESERKRGIIEQGLSDQRSVIVVNTKTVDKEMIISRRSTYQKVLAMEKEGVQVVERDSDLPVDLMLSPAVCLLWYDSETVSKKSAATIGTSSSSLSWIGDIATNVLTSLSFSFSTCIMVFEGEPAFLAAVMDSSDELYAAAGSLGISLQMFCSSSANLTDEIILKCIKSSVKLSKLHVKMPESESLAESFLTKFPSVNPLTAQVILSSSGSLLEFMKLPHKSKVERTQKYHVPEESVDLFSSVCRYGAREDSRSVMTDSSSSVSSGPDSDTHHVSVHSGSKKKQYIAEKDEIDMDDLVHFSPSIEFADTQLKSSGDFQLDDSWSSKDHEIFHFDPVTEFSDAPFKPSGISHPNDSWPSKDPERFDKKSGPGSSSKDTFWEKDQPDFSVEDSLPGIPELEDWSFPVKDKFMSQNRGCKFPVMRDFNLHDNRNSENFIADYKGEVIDRADKYLEEDFPPSPGYNRFARIVSDVNEEELPRKSKSSRKLSFFGSLQPNFPKAADIDSSSERYATEKDSKYDNNTSLRGYADNYPAKRQRTLLEEVLTRRSAVPTTELPFREEISHFGGSPLSNAIRSSNQVQSSPWTVDFLNRVRERSRARKQQQSLPSYASPPSLETPGNIKKANTKRKSPSILEFFKYKGGNKLQEEKRQKRSKNSSASPKNERFYSPLKSCTPIDKRAKQSLSYTANGTGQTKLVWK

Shoc1

Protein shortage in chiasmata 1 ortholog

1481 amino acids

ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity).

Belongs to the XPF family. Highly divergent.

168.065 kDa

MALNGRTMFPAFKYYAIDYLQEDIIKERLYRDALLLQIPSCLNQDKNIIDDKYRTPWTRAIPVQEMEDNSVLEQWRTRFCVEGVPEKKTVTGVMINGTFEEIVPSSNPNSPPGIENDKLFPSKDYVDDFIPVKCSLYYPGVKAEHQGLLIDEEMIFMNKAMDNHLPTVNGLLSRLKLYLVKDPFLDFKEELSGKDNFTEYFSVQECSEPFVRDFHMAEETFCKKKLPSVFPSGFKSLISTNPKQEILILPPSKLKKPLNSIPKIMDSVDESECFKGDITSKHEFDTEDIKCNSTENLTFASLCEPECSEPGDLEMPPTHLILPRQHSAVSSLHMGFQTFPFSATCKINLLSAGESANKYCMLWQLGGCRNSWVSFLLTVPRFQEPSSQYSLADMRNIFSVKGDSLVINPAKAKGWRQARLHPIMAETLAHLKAYLCHNGLSSQETKLEIFLPTKVFQLESWLELKSRPLPIVPISEKSTDVHQLHPQKRPIPSSEKEVPHLCLSGESISVKKSKVEANPKNDQEPEARIMQKPENSCVGLGCSSQVPSAESASSSQIQASYDKKQDDLDLLSEFIILRSKHQTFPSEADVDVKSHDHDQNNEFQDKEKYSLTLQEESLVASNSKAPEERCEERTDGVIEIPASDTQCQAYCLLEATANPILKELVCLCTYPAANWKFATVNFDQTRFFLKEQEKKINDATHPDKNDDRKMTFRHAALLHLLITIRDVLLTCNLDTALGYLSNAKDIYKSVLDSRLDNIWRQLKILQFIKEKRPKSNYKIQELQCQILSRLQNQQQMKVLIIIRMDSDGEKHLLIKTLKKIEGLTMTVLRSNDRKKILETTSILKGTNACVVVHNHSIGADFPWSSFSLVVEYNHVGHSCWAEHCQLLDIPFLAFKVAVPDTALQRDALLDGFGGFLLKIPIPYVFFASEGLLNTPEILRLLESNYNITLVERCCCGSLKLFGSTECYVVVTVDEHTAIVVQDLEELHHEKASDNIIMRLMALSFQYSCCWIILYSKETLNSQYHLTEETLRHLAQVYAALVSSGLKSEELDVKLIIAPGVEETALIIRQIADHNLMTSTRDPHEWLDKSWVEVSPSKEEMSLLDFPCINPLVAQLMLHRAPSLHWLLIATPAELQELLPQVPGKVLKHFCSITSLFKISSPSMTKSSQISSLQEDMNQTDLFISQSSAPIIQEQEEYYPYEDSEGTSSSPVELRATPCMLPSAAPHSQRGCWEDPSCGPDPVQNNPSLMNAESKKVTWPSVPSWSDSESDVFSLARTQVSCEPIMTLTDSQRRGTNGFVNCPEAKGPRNMQVSTPVFLPENSQSHLHWDFKKNSCRKQIYSFNPSCGTEQTTYNKWYSWKDDFSSNQPECLWDEMEDVTYRNANAGTRETFWRELPAVPSWDSPCASDSNANQRGFKGLDFCQRAGNYLGQRSLPVSSSNWGDYKTPTDLMYSQVPQPKKRRLMYEKVPGRVDGQTRLKFL

SHOC1

Protein shortage in chiasmata 1 ortholog

1444 amino acids

ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103).

Belongs to the XPF family. Highly divergent.

165.202 kDa

MTDTSVLDQWKASFFVEDFLEKKTITRMVTQINCEFEEVVPSSNPDSQIEVEEVSLYTHMDYNEVFTPVSCLEKCSALQNQNQDLFIDDKGILFVSSRKHLPTLPTLLSRLKLFLVKDPLLDFKGQIFTEANFSRECFSLQETLEAFVKEDFCMDKVNFCQEKLEDTICLNEPSSFLIEYEFLIPPSLKPEIDIPSLSELKELLNPVPEIINYVDEKEKLFERDLTNKHGIEDIGDIKFSSTEILTIQSQSEPEECSKPGELEMPLTPLFLTCQHSSVNSLRTELQTFPLSPVCKINLLTAEESANEYYMMWQLERCRSPLNPFLLTVPRIQEPHSQYSVTDLKKIFSVKEESLVINLEKAEWWKQAGLNLKMMETLEHLNTYLCHDNLSSNDTKIEIFLPTKVLQLESCLEHKSHSSPIALIDEKSTNAHLSLPQKSPSLAKEVPDLCFSDDYFSDKGAAKEEKPKNDQEPVNRIIQKKENNDHFELDCTGPSIKSPSSSIIKKASFEHGKKQENDLDLLSDFIMLRNKYKTCTSKTEVTNSDEKHDKEACSLTLQEESPIVHINKTLEEINQERGTDSVIEIQASDSQCQAFCLLEAAASPILKNLVSLCTLPTANWKFATVIFDQTRFLLKEQEKVVSDAVRQGTIDEREMTFKHAALLHLLVTIRDVLLTCSLDTALGYLSKAKDIYNSILGPYLGDIWRQLEIVQFIRGKKPETNYKIQELQCQILSWMQSQQQIKVLIIIRMDSDGEKHFLIKILNKIEGLTLTVLHSNERKDFLESEGVLRGTSSCVVVHNQYIGADFPWSNFSFVVEYNYVEDSCWTKHCKELNIPYMAFKVILPDTVLERSTLLDRFGGFLLEIQIPYVFFASEGLLNTPDILQLLESNYNISLVERGCSESLKLFGSSECYVVVTIDEHTAIILQDLEELNYEKASDNIIMRLMALSLQYRYCWIILYTKETLNSEYLLTEKTLHHLALIYAALVSFGLNSEELDVKLIIAPGVEATALIIRQIADHSLMTSKRDPHEWLDKSWLKVSPSEEEMYLLDFPCINPLVAQLMLNKGPSLHWILLATLCQLQELLPEVPEKVLKHFCSITSLFKIGSSSITKSPQISSPQENRNQISTLSSQSSASDLDSVIQEHNEYYQYLGLGETVQEDKTTILNDNSSIMELKEISSFLPPVTSYNQTSYWKDSSCKSNIGQNTPFLINIESRRPAYNSFLNHSDSESDVFSLGLTQMNCETIKSPTDTQKRVSVVPRFINSQKRRTHEAKGFINKDVSDPIFSLEGTQSPLHWNFKKNIWEQENHPFNLQYGAQQTACNKLYSQKGNLFTDQQKCLSDESEGLTCESSKDETFWRELPSVPSLDLFRASDSNANQKEFNSLYFYQRAGKSLGQKRHHESSFNSGDKESLTGFMCSQLPQFKKRRLAYEKVPGRVDGQTRLRFF