Protein
SH2 domain-containing protein 4A
Organism
Rattus norvegicus
Function
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function (By similarity).
Sequence
MLRQILSEMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGKSVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAEREHLRAAKDAELRKAQSLQFTNSLKVKSLNCDLQAVKKTEPQNVTRKAAAEEATDQGPRAIPTKKDDKAQTKDLTKKKDSEELKQTEDEKTKQIYKNWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPKRPPLPPKPQFLQPLGSPPKSLGNQGVIRTKTSSTQEDIIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKANELLSTGMPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLFPCGQQDKPPDYLELFQ