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SELENOK

Gene
SELENOK
Protein
Selenoprotein K
Organism
Bos taurus
Length
95 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.805 kDa
Sequence
MVYISNGQVLDSRSQSPWRLSFITDFFWGIAEFVVLFFRTLLQQDVKKRRGYGSSSDSRYDDGRGPPGNPPRRRMGRINHLQGPNPPPMAGGUGR

Gene
selenok
Protein
Selenoprotein K
Organism
Xenopus laevis
Length
95 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Required for palmitoylation (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.418 kDa
Sequence
MVYISNGQVLDGQSRSPWRLSFLTDMFWGITDFVVMFFQSIIHPNVTRRGCQNSSSSTRYDDGRGPPGHPRRMGRINHGSGPSAPPMAGGGGUGR

Gene
selenok
Protein
Selenoprotein K
Organism
Xenopus tropicalis
Length
95 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Required for palmitoylation (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.646 kDa
Sequence
MVYIANGQVLDGQSRSPWRLSFLTDMFWGITDFIVMFFQSIIHPNVTRRGCQNSSSRTRFDDGRGPPGNPRRRMGRIDHNSGPNAPPMSGGGUGR

Gene
SELENOK
Protein
Selenoprotein K
Organism
Chinchilla lanigera
Length
94 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.569 kDa
Sequence
MVYISNGQVLDSRSQSPWRLSLITDFFWGIAEFVVLFFKTLLQQDVKKGRGYRNSSDSRYDDGRGPPGNPPRRMGRISHLHGPSPPPMAGGUGR

Gene
selenok
Protein
Selenoprotein K
Organism
Danio rerio
Length
94 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Required for palmitoylation (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.153 kDa
Sequence
MVYVSNGQVLDSRSRSPWSLSFLTDFFWGAVEFIGLFFQTLVQPDLSKDGNNSASSRFSDGRGPPGFPGRRRMGRINHGAGPTPPPMGGGGUGR

Gene
SELENOK
Protein
Selenoprotein K
Organism
Homo sapiens
Length
94 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588).
Similarity
Belongs to the selenoprotein K family.
Mass
10.645 kDa
Sequence
MVYISNGQVLDSRSQSPWRLSLITDFFWGIAEFVVLFFKTLLQQDVKKRRSYGNSSDSRYDDGRGPPGNPPRRMGRINHLRGPSPPPMAGGUGR

Gene
SELENOK
Protein
Selenoprotein K
Organism
Macaca fascicularis
Length
94 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.645 kDa
Sequence
MVYISNGQVLDSRSQSPWRLSLITDFFWGIAEFVVLFFKTLLQQDVKKRRSYGNSSDSRYDDGRGPPGNPPRRMGRINHLRGPSPPPMAGGUGR

Gene
Selenok
Protein
Selenoprotein K
Organism
Mus musculus
Length
94 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (PubMed:21220695). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (PubMed:23444136). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (By similarity). Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.642 kDa
Sequence
MVYISNGQVLDSRNQSPWRVSFLTDFFWGIAEFVVFFFKTLLQQDVKKRRGYGSSSDSRYDDGRGPPGNPPRRMGRISHLRGPSPPPMAGGUGR

Gene
SELENOK
Protein
Selenoprotein K
Organism
Sus scrofa
Length
94 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.619 kDa
Sequence
MVYISNGQALDSRSQSPWRLSFITDFFWGIAEFVVLFFRTLLQQDVKKRRGYGGSSDSRYDDGRGPPGNPPRRMGRINHLRGPNPPPMAGGUGR

Gene
Selenok
Protein
Selenoprotein K
Organism
Rattus norvegicus
Length
94 amino acids
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
Similarity
Belongs to the selenoprotein K family.
Mass
10.626 kDa
Sequence
MVYISNGQVLDSRNQSPWRLSFITDFFWGIAEFVVFFFKTLLQQDVKKRRGYGGSSDSRYDDGRGPPGNPPRRMGRISHLRGPSPPPMAGGUGR