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SEC61

Gene
SEC61
Protein
Protein transport protein SEC61
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
480 amino acids
Function
Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. In an initial step, the signal sequence seems to bind simultaneously to SEC61 and SEC62. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC61 mediates the association with the ribosome.
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
52.937 kDa
Sequence
MSSNRVLDLFKPFESFLPEVIAPERKVPYNQKLIWTGVSLLIFLILGQIPLYGIVSSETSDPLYWLRAMLASNRGTLLELGVSPIITSSMIFQFLQGTQLLQIRPESKQDRELFQIAQKVCAIILILGQALVVVMTGNYGAPSDLGLPICLLLIFQLMFASLIVMLLDELLSKGYGLGSGISLFTATNIAEQIFWRAFAPTTVNSGRGKEFEGAVIAFFHLLAVRKDKKRALVEAFYRTNLPNMFQVLMTVAIFLFVLYLQGFRYELPIRSTKVRGQIGIYPIKLFYTSNTPIMLQSALTSNIFLISQILFQKYPTNPLIRLIGVWGIRPGTQGPQMALSGLAYYIQPLMSLSEALLDPIKTIVYITFVLGSCAVFSKTWIEISGTSPRDIAKQFKDQGMVINGKRETSIYRELKKIIPTAAAFGGATIGALSVGSDLLGTLGSGASILMATTTIYGYYEAAAKEGGFTKNLVPGFSDLM

Gene
SEC61
Protein
Protein transport protein SEC61 subunit alpha
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
480 amino acids
Function
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
52.732 kDa
Sequence
MSGRLLDLFKPFEAFLPEVIAPERKVPYNQKLIWTAVSLLIFLVLGQIPLYGIVSSEGSDPLQWLRAMLASNRGTLMELGVSPIITSSMIFQFLQGTQLLQVNLESKQDRELFQIAQKVCAIVLTLGQAIVVVLTGNYGSVSNLGIAISLLLILQLVFASFIVLLLDELLIKGYGLGSGISLFTATNIAEQIFWKAFAPTTVNNGRGTEFEGAVVALFHLLSVRKDKKRALVEAFYRDYLPNMFQVLSTVFVFLFVLYLQGFRYELPVRSTRTRGQVGSYPIKLFYTSNTPIMLQSALTSNIFLTSQLLYQKFPNNPIVKMLGVWGTRSDAPYSPNAAISGLSYYIQPPFSFTEALLDPIKTVVYVTFVLGACAMFSRTWIDVSGTSPRDVSKQFKEQGLVINGRRETSVYRELKKVIPTAAAFGGATIGALSVGSDLLGTLGSGTSILMATTTIYGYYETAAKEGGFAKNLVAGFSEML

Gene
SEC61
Protein
Protein transport protein SEC61 subunit alpha
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
480 amino acids
Function
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
52.631 kDa
Sequence
MSGRVLDLFKPFEAYLPEVIAPERPVPYKQKLIWTGVSLLVFLVLGQIPLYGIVSSETSDPLYWLRAMLASNRGTLMELGVSPIITSSMIFQFLQGTQLLQVNMENKQDRELYQIAQKVFAILLTFGQAIVVVLTGNYGKPSDLGLAISLLLIFQLIFASFTVLLLDELLSKGYGLGSGISLFTATNIAEQITWKAFAPTTVNVGRGQEFEGAVIALFHLLAIRKDKKRALVEAFYRENLPNMFQVFSTIGVFLSVLYLQGFRYELPIKSTRTRGQYGSYPIKLFYTSNTPIMLQSALTSNIFLISQILYQRFSTNPLVKLLGVWGTRAGAPAGQQVALSGLSYYIQPPFSVTDALLDPIKTVVYVGFVLGACALFSKTWIEISGTSPRDVAKQFKDQGLTINGKRETNVYKELKKIIPTAAAFGGAVIGALSVGSDLLGTLGSGTSILMATTTIYGYYEVAAKEGGFTKNLVSGFSEMM

Gene
SEC61
Protein
Protein transport protein SEC61 subunit alpha
Organism
Wickerhamomyces anomalus
Length
479 amino acids
Function
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
52.972 kDa
Sequence
MSSFRVLDLVKPLTGYLPEVIAPERKVPFNQKLMWTGVTLLIFLVMSEIPLYGIVSSESSDPLFWLRMMLASNRGTLMELGISPIVSSGMVFQLLQGTQLLDVNLESKTDRETFQTAQKLFAILLSIGQATVYVLTGIYGRPSDLGVGVCLLLILQLVFAGIIVILLDELLQKGYGLGSGISLFMATNICEQIFWKAFAPTTVNNGRGDEFEGAVVALFHLLSVRKDKRRALVEAFYRQNLPNIFQLLATFIVFFLVVYLQGFRYEIPVRSTRQRGQNGLYPIKLFYTSNTPIMLQSALTSNFFIISQMLFQRFPLNPVVRLFGVWDARPGSAQLFASNGLAYYIQPPLSLTEALLDPIKTVIYVSFVLSVCALFSKTWIEISGTAPRDVAKQFKDQGLVIAGRRETSVYKELKRIIPTAAAFGGASIGALSVACDLLGTLGSGTSILLAVTTIYSYYEIAAKEGGFQKHIVEGFSEAF

Gene
SEC61
Protein
Protein transport protein SEC61 subunit alpha
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
479 amino acids
Function
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
52.52 kDa
Sequence
MSGFRVLDLVKPFSPFLPEVIAPERKVQFQQRVMWTIITLLIFLVMSEIPLYGIASSDSSDPLFWLRMMLASNRGTLMELGISPIVSSGMLFQLLQGTKIIHVDMQNKNDRETFQTAQKLLAILLAVGQATVYVLTGMYGPPSSLGVGVCSLLILQLVFASTIVILLDELLQKGYGLGSGVSLFTATNTCEQVFWKAFAPTTSTSAKGTEFDGAVVAMFHLLGSRKDKKRALIESFYRPNLPNMFQLLATLLVFFAVVYLQGFRIELPMKSTRQRGPYGSYPIRLFYTSNIPIMLESALASNIFIISQLLFMRWPNNLFVKLLGTWDARAGSSQLYANGGLAYYIQPPFNFTDALLDPIKTTIYIAFVLGSCAVFSTTWIEISGTSPRDVAKQFKEQGLVIAGHRDTSAYKELKKIIPIAAAFGGATIGALSVVCDLMGTLGSGTSILLAVTTIYGYYELAVKEGGFNKSIVSGFSDGI

Gene
SEC61
Protein
Protein transport protein SEC61 subunit alpha
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
479 amino acids
Function
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
52.64 kDa
Sequence
MSDRILSLFKPFEAFLPEVISPERKVPYNQKLIWTGVSLLIFLVLGQIPLYGIVSAETSDPLYWLRAMLASNRGTLMELGVSPIITSSMIFQFLQGTQLLQVSLDSKEDRELYQIAQKVCAIILTFGQALVVVMTGNYGSPSDLGIAISLLLIFQLMFASFIVLLLDELLTKGYGLGSGISLFTATNIAENIFWKAFAPTTVNSGRGKEFEGAVIAFFHLLAVRKDKKRALVEAFYRENLPNMFQVIATVFVFLFVLYLQGFRYELPVKSTKVRGQMAIYPIKLFYTSNTPIMLQSALSSNIFLISQILFQKYPSNPVIRLFGVWGIRPGTNGPQVPLSGISYYLQPIGSLKMALLDPIKTVIYTAFVLGTCALFSKTWIEISGTSAKDVAKQFKEQGMVINGKRETSVYKELKKIIPTAAAFGGATIGALSVGSDLLGALGSGASILLATTTIYGYYEVAAKEGGFTKNLVNGFSEMM

Gene
SEC61
Protein
Protein transport protein SEC61 subunit alpha
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
479 amino acids
Function
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
52.518 kDa
Sequence
MSGFRVLDLVKPFTPFMPEVIAPERKVAFQQRLMWTGVTLLIFLVMSEIPLYGIASSDGSDPLYWLRMMLASNRGTLMELGISPIVSAGMVFQLLQGTKLITVDMSNKNDRDQFQTAQKLFAILLAVGQATVYVLTGMYGPPSSLGTGVCLLLVLQLVFAGIVVILLDELLQKGYGLGSGISLFTATNVCEQVFWKAFAPTTSNIGKGTEFEGAVVALFHLLGSRKDKKRALLEAFYRSHLPNMFQLIATVFVFLLVVYLQGFRIELPIKSTRQRGPYGLYPIRLFYTSNIPIMLQSALSSNIFIISQMLFVRWPNNIFVKILGSWDTRQGAAQLYAVSGLAYYIQPPLSFTEALLDPIKTIIYIIFVLGSCAVFSTTWIEISGASPRDVAKQFKEQGLVIAGHRDTSAYRELKKIIPTAAAFGGATIGALSVFCDLMGTLGSGTSILLSVTTIYGYYELAMKEGGFGKSVVSSFSDGI

Gene
sec61
Protein
Protein transport protein sec61 subunit alpha
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
479 amino acids
Function
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to sec62/63 complex, secretory precursor polypeptides may engage sec61 to begin membrane penetration event. A cycle of assembly and disassembly of sec62/63 from sec61 may govern the activity of the translocase (By similarity).
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
53.254 kDa
Sequence
MSDLRFLDLVKPFAPFLPEIAAPERKVPFKQKMLWTGVTLLIFLVMSQVPLYGIVSSDSSDPLLWLRMILAANRGTLMELGISPIVTSSMLVQLLVGSQLIEVNMELKSDREMYQLVQKFLAIIIAFGQATAYVLTGMYGRPQDLGAGICLLLILQLAAASLIVLLLDELLQKGYGLGSGISLFIATINCENIFWKAFSPTTYHIANGVQFEGAVINFVYVMFTWDNKAAALYQAFFRSGLTSSQIQLPNLWNFFATLLVFGVVIYLQDFRVEIPIRSQKFRGYRSTFPVKLLYTSNTPIMLQSALTSNLFFASRLLFNRFSSNFLVRFLGVWEQTATSGLSYYLSPPASFQDALIDPIHTLVYVFFTMFACALFSKLWIEVSGASPRDVAKQLKSQQLVMAGHREGSMYKELKRIIPTAAWLSGAVVGALAVASDLLGALGSGTAVLLCTTTIYGYYEQLQKEIKGDQYGLPVTPMMQ

Gene
SEC61
Protein
Protein transport protein SEC61 subunit alpha
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
471 amino acids
Function
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
Similarity
Belongs to the SecY/SEC61-alpha family.
Mass
51.687 kDa
Sequence
MAGVRFLDLVKPFTPFLPEVQAPERKVPFNQKIMWTAVTLMIFLVMSEIPLYGINSSDKSDALYWLRMMLASNRGSLMELGITPIVSSGMVFQLLGGTQLIEVNMDLKSDRELYQTAQKLFAIILSLGQATVYVLTGMYGPPKDLGVGVCLLLIFQLVLAALVVILLDELLQKGYGLGSGISLFIATNICEQIFWKAFAPTTVNKGRGYEFEGAIVAFVHLLFTRKDKKRAIIEAFTRQDLPNMSQLVTTVAIFAAVIYLQGFRVDIPVKSSKQRGPYGVFPIKLFYTSNLPIMLQSALTSNIFIISQMLFKKFPTNVLVRLLGVWDGREGMQQLFPVSGIAYYMQPPFNAKEALADPVKTVIYIAFVLGVCAVFSATWIEISGSSPRDVAKQFKEQGLVIAGRRETSAYKELKRIIPTAAAFGGATIGALSVASDLLGALSSGTGILMAVTTIYGYYEMAAKEGYVDAAI