SEC14L1

SEC14-like protein 1

715 amino acids

May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).

81.25 kDa

MVQKYQSPVRVYKYPFELIMAAYERRFPTCPLIPMFVGSDTVNEFKSEDGAIHVIERRCKLDVDAPRLLKKIAGVDYVYFVQKNSLNSRERTLHIEAYNETFSNRVIINEHCCYTVHPENEDWTCFEQSASLDIKSFFGFESTVEKIAMKQYTSNIKKGKEIIEYYLRQLEEEGITFVPRWSPPSITTSSETSSSSSKKQAASMAVVIPEAALKEGLSGDALSSPSAPEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKDEHILRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILETWTPPQVLQDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCEVPEGGLVPKSLYRTAEELENEDLKLWTETIYQSASVFKGAPHEILIQIVDASSVITWDFDVCKGDIVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGESVQGSHVTRWPGFYILQWKFHSMPACAASSLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSMTSLESSHSGFSQLSAATTSSSQSHSSSMISR

Sec14l1

SEC14-like protein 1

715 amino acids

May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters.

81.216 kDa

MVQKYQSPVRVYKHPFELIMAAYERRFPTCPLIPMFVDSDTVSEFKSEDGALHVIERRCKLDIDAPRLLKKIAGVDYVYFVQKNSLNSRDRTLHIEAHNETFSNRVIIHEHCCYTVHPENEDWTCFEQSASLDIKSFFGFESTVEKIAMKHYTSNIKKGKEIIEYYLRQLEEEGITFVPRWTPPPVGPSETCSSSKNQVTSAAVLVPDAAAVMEGLSGENLSSPGTASEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKDEHILRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILDTWTPPQVLLDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCDVPEGGLVPKSLYRTAEELENEDLKLWTETIYQSASVFKGAPHEILIQIVDASSVITWDFDVCKGDIVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGESVQGSHVTRWPGFYILQWKFHTMPACAATNLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSMTSLESSHSGFSQLSAATTSSSQSQSSSMISR

sec14l1

SEC14-like protein 5

707 amino acids

80.502 kDa

MVQKYQSPVRVYKYPFELVMAAYEKRFPTCPQIPVFLGSDILQEHKSEDGALHVVERSCKLNVDAPRLLKKIAGVEFVYFIQKNTVNWKDRTLLIEAHNETFSSRVLVNETCSYSVHPENEEWTCFEQTASLDIKSFFGFESTVEKIAMKQYTANIKRGKEVIEFYLNELISQGITHLPKWTPGVPAGWHPLQAFRSGITRSNQAEQTASQGPCKADAGSHSLAAEPSTPDTDKLEADYIERYLGQLTPMQESALIHLRQWLQETHKGKIPKDEHILRFLRARDFNMEKAREMLCQSLSWRKQHQVDYILQTWQPPRVLEEYYAGGWHYHDKDGRPLYILRLGQVDTKGLVKALGEEAILRHVLSINEEGQKRCEENTRQFGRPIWSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLIVRAPRVFPVLWTLVSPFINENSRQKFLIYSGNNYQGPGGIADYVDKEIVPDFLGGECVCNIPEGGLVPKSLYQSDEDAEMSDHIRLWTETIYQSSCVWKGAPHEIIVEILEEESVITWDFDILRGDVIFSLFHSKRAPDTRQRELALAAGNAPSSNVQLIDKSWTLGVDYSRVQAPLVCREGESIQGSHVTRWPGIYILQWKMHSSASGSSMARVDDVLASLQGSSHKCKLMYYFEVLASEDFRGSMSSLESCSGFSQLSGVTNTSSKSHSSSLISR