Protein
Succinate dehydrogenase 2 membrane subunit SdhC
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function
Membrane-anchoring subunit of succinate dehydrogenase 2 (Sdh2). Sdh2 may catalyze the two-electron oxidation of succinate to fumarate with a corresponding reduction of quinone to quinol under low oxygen conditions, when the primary aerobic succinate dehydrogenase (Sdh1) is inhibited. Sdh2 seems to be the generator of the proton motive force (PMF) under hypoxia.
Similarity
Belongs to the cytochrome b560 family.
Sequence
MLLRGLPAVNTTATTVSRGRRPPRTLYRGDPGMWSWVCHRISGATIFFFLFVHVLDAAMLRVSPQTYNAVLATYKTPIVGLMEYGLVAAVLFHALNGIRVILIDFWSEGPRYQRLMLWIIGSVFLLLMVPAGVVVGIHMWEHFR