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SCNN1A

Gene
Scnn1a
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Mus musculus
Length
699 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
78.893 kDa
Sequence
MLDHTRAPELNLDLDLDVSNSPKGSMKGNNFKEQDLCPPLPMQGLGKGDKREEQALGPEPSEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEALGSFIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGTTPPLALTAPPPAYATLGPSASPLDSAVPGSSACAPAMAL

Gene
Scnn1a
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Rattus norvegicus
Length
698 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells (PubMed:8382172). Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception (By similarity).
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
78.888 kDa
Sequence
MLDHTRAPELNIDLDLHASNSPKGSMKGNQFKEQDPCPPQPMQGLGKGDKREEQGLGPEPSAPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYLSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEELEELDRITEQTLFDLYKYNSSYTRQAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEALGNFIFTCRFNQAPCNQANYSKFHHPMYGNCYTFNDKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYRKQSSWGYCYYKLQGAFSLDSLGCFSKCRKPCSVINYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLRRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGMTPPLALTAPPPAYATLGPSAPPLDSAAPDCSACALAAL

Gene
SCNN1A
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Pan troglodytes
Length
692 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
78.073 kDa
Sequence
MSSIKGNKLEEQGPRPLQPTPGLMEGNKLEEQDSSPPQSTPGLMKGDKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSVRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEKDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPTSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSTGAGSSACPLGGP

Gene
SCNN1A
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Cavia porcellus
Length
682 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
77.071 kDa
Sequence
MLMRLLPLPSLTDGRPLGCCCTCQGSMKGDELKAQGPLPPQPLQGPLKGDKCEQPGLGPEPTAPQQHTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFGEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYKEIKEQLRELDRITQQTLFDLYNYNASSTLLAGARSRRSLADTLPYPLQRIPVQPEPRRARSSDPSSVRDNNPRVDRRDWRVGFQLCNQNKSDCFYQTSSSGVDGVREWYRFHYINILAQVADTSPRWEEETLGNFIFACRFNQAPCTQENYSHFHHPIYGNCYTFNNKNDSSLWMASMPGINNGLSLTLRTEQNDYIPLLSTVTGARVTVHGQDEPAFMDDGGFNLRPGVETSISMRKEALDRLGGSYGDCTQDGSDVPVQNLYPSKYTQQVCIHSCFQENMIKQCGCAYIFYPKPKGVEFCDYTNHSAWGYCYYKLQGAFSSDSLGCFNKCRKPCNVTIYKLSAGYSRWPSAASQDWIFQMLSLQNNYTISNKRNGVAKLNIYFKELNYRTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEFMFDLLVITLLMLLRRFRSRYWSPGRGARAAREVACTPPPSLPSRFCAHSAFPTLTAPPPAYATLSACPPLQGLAGASSAACAPREP

Gene
SCNN1A
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Homo sapiens
Length
669 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
75.704 kDa
Sequence
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP

Gene
scnn1a
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Neoceratodus forsteri
Length
655 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
73.378 kDa
Sequence
MTDKEEEAEGGKKKEPMIGFYDSYQELFEFFCNNTTIHGTIRMVCSKHNNMKTVSWTILFITTFGVMYWQFGLLLGQYYSYPVSITMSVNFDKLIFPAVTVCTLNPYRYNVVSTQLANLDCYTEELLSTLYHYNPLTSGNQSACNSSSTAGTRAFDESYMKLEFLNDENTAYSGPVKGATNSTSPVNHTEFYRIGFKLCNATGEDCFYQTYSSGVDALREWYKFQYINIMAQIPSQSNQEDDSQISNFVYACEFNKVSCGVENYTRFRHPVYGNCYTYNDGQSATPWASFVPGVGNGLSLVLRTEQNDFLPFLSTVAGARVLVHDQNQPPFMEDSGLDIRPGVETSIGMKKEIISRLGGVYGNCTDGSDIDVVNLYNSDYNQQACVRSCFQATIVQQCGCGYYFYPLPSGAEYCSYSRNKSWGYCYYKLYKAFAADELGCFRRCRKPCQYTDYKMTAGYAQWPSSVSESWITSILSQENQYNMTSGRKNIAKLNVYFYELNYQTMGESPSFTVVTLLSNMGSQWSLWFGSSVLSVVEMGELVFDLIAVGVIVLRRRRREKCQASSDGEGTSDSTAGTHRGQENASRSGRDVACNRFVVVAEISPPPAYDTLQLDVPVACAPDCECTQHVSHASVHSQAPCSSQPEQEASEGPTVL

Gene
SCNN1A
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Bos taurus
Length
650 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
73.793 kDa
Sequence
MKGDKPEEPGPGPEPSGPPPPTEEEEALLEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTVFWAVLWLCTFGMMYWQFGQLFGEYFSYPVSLNINLNSDKLVFPAVSICTLNPYRYKEIQEELEELDRITEQTLFDLYKYNSSKTLVAHARSRRDLREPLPHPLQRLPVPAPPHAARGVRRAGSSMRDNNPQVNRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRRRQDTSPSLEEDVLGKFIFTCRFNQDSCNEANYSHFHHPMYGNCYTFNDKNSSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHERDEPAFMDDAGFNLRPGVETSISMSKEAVDRLGGDYGDCTKNGSEVPVENLYNTKYTQQVCIHSCFQESMIKECGCAYIFYPRPDGVEFCDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKPCSVTIYKLSASYSQWPSATSQDWVFQMLSRQNNYTIKNKRDGVAKLNIFFKELNYKSNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIIDLLVITFLMLLRRFRSRYWSPGRGGKGTQEVASTPAASLPSSFCPHPAFFSSSPPDPAISPALSAPPPAYATLGPHPAPSGLAEASTSAHAPGEP

Gene
SCNN1A
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Pelodiscus sinensis
Length
642 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
73.892 kDa
Sequence
MHQVVTVKAEKVPMGKRLRRCKQEAENQQKVEEVAEKLEKEHEGLIEFHKSYHELFQFFCNNTTIHGAIRLVCSKRNKMKTAFWSVLFFLTFGLMYWQFGILYREYFSFPVNLNLNLNSDKLTFPAVTLCTLNPYRYSAVRKELDELDRITHQTLMDLYNYSMSQVQSNGAAQSSQKRSQRSLSHHVQRHPLRRRKRNEPVSLKGNSPPVDKSDWKIGFILCNETNEDCFHQTYSSGVDAVREWYSFHYINILARMPDTKALDESNFESFIYACRFNEVTCDKANYTHFHHPLYGNCYTFNDRNNSLWTSSLPGINNGLSLLVRTEQNDYIPLLSTVTGARVMVHEQNEPAFMDDGGFNVRPGIETSISMRKETTMLLGGSYSDCTEDGSDVPVQNLYSSRYTEQVCIRSCFQIHMVKRCGCAYYFYPLPPGAEYCDYTKHIAWGYCYYKLQVEFKSNILGCFSKCRKPCEVTKYQLSAGYSHWPSAVSENWVFHILSQQNKYNITSKRNGVAKVNIFFEEWKYKTNGESPAFTVVTLLSQLGNQWSLWFGSSVLSVVELAELILDFIAITIILSFKRFRSRQVPAPSVPPPGAHDNTAFQSEPADPSAPHRFTVEAVVTTLPSYNSLEPCRRDGEAVIGLE

Gene
SCNN1A
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Oryctolagus cuniculus
Length
640 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
72.734 kDa
Sequence
MKGDKREEQGPGPETVAPQQPTEDEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVNLNINLNSDKLVFPAVTVCTLNPYRYPEITEQLKELDSITQQTLLDLFKYNASTLEAQPRHRRDVHPPLPHPLQRLRVPPPRLEARRARSSASSVRDNSPEVGRKDWMIGFQLCNQNRSDCFYQRYSSGVDAVREWYRFHYINILSRLSDTSLSREQLGNFIFTCRFNQAFCGDGNYSHFHHPMYGNCYTFNDKNNSSLWMSSMPGINNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKESLDRLGGDYGDCTQNGSDVPVKNLYRSKYTQQVCIHSCFQENMVKECGCAYIFYPLPEGVEYCDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKPCSVTNYELSAGYSRWPSVTSQDWVFQMLSLQNNYTVSNKRNGVAKLNIYFKELNYKANSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELLFDLSVITFLMLLRRFRSRYWSPGRGAGGAREVASSPVSALPSRFCPHPTSPSVPQPGPTLPPSLTAPPPAYATLGPCLSQSGSACAPGEP

Gene
SCNN1A
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Gallus gallus
Length
637 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
73.236 kDa
Sequence
MGTASRGGSVKAEKMPEGEKTRQCKQETEQQQKEDEREGLIEFYGSYQDVFQFFCSNTTIHGAIRLVCSKKNKMKTAFWSVLFILTFGLMYWQFGILYREYFSYPVNLNLNLNSDRLTFPAVTLCTLNPYRYSAIRKKLDELDQITHQTLLDLYDYNMSLARSDGSAQFSHRRTSRSLLHHVQRHPLRRQKRDNLVSLPENSPSVDKNDWKIGFVLCSENNEDCFHQTYSSGVDAVREWYSFHYINILAQMPDAKDLDESDFENFIYACRFNEATCDKANYTHFHHPLYGNCYTFNDNSSSLWTSSLPGINNGLSLVVRTEQNDFIPLLSTVTGARVMVHDQNEPAFMDDGGFNVRPGIETSISMRKEMTERLGGSYSDCTEDGSDVPVQNLYSSRYTEQVCIRSCFQLNMVKRCSCAYYFYPLPDGAEYCDYTKHVAWGYCYYKLLAEFKADVLGCFHKCRKPCKMTEYQLSAGYSRWPSAVSEDWVFYMLSQQNKYNITSKRNGVAKVNIFFEEWNYKTNGESPAFTVVTLLSQLGNQWSLWFGSSVLSVMELAELILDFTVITFILAFRWFRSKQWHSSPAPPPNSHDNTAFQDEASGLDAPHRFTVEAVVTTLPSYNSLEPCGPSKDGETGLE

Gene
SCNN1A
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Anolis carolinensis
Length
636 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
73.384 kDa
Sequence
MKSENQPEDKRIGKLKREANMQKMKEAAEVEEKKKEENEALVGFFHSYQELFQFFCNNTTIHGAIRLVCSKKNRMKTAFWSILFFFTFGLMYWQFGIIYREYFSFPVNLNLNLNSDRFTFPAVTLCTLNPYRYSALQNELAELDHITQKTLMDLYKYDMSQGQNNRKAQLSRKRSYRSLHYHVSRHPLHRYKRDSQASIEDNNTQVDKNDWKIAFSVCNENNTDCFKQMYSSGVDAVREWYSFHYINILSRIPNAKSLDESDFASFIYACRFNEVTCDKANYTHFHHPIYGNCYTFNANSSNLWMSSLPGINNGLSLVVRTEQNDFIPLLSTVTGARVMVHNQNEPAFMDEGGFNVRPGIETSISMRKETTNRLGGTYSDCTEDGSDVPVKNLYTSRYTEQVCIRSCFQNSIVERCGCGHYFYPLPSGAVYCDYAKHKAWGYCYYKLLAEFKADLLGCFTKCRKPCKVTEYQLSAGYSRWPSTASEAWVFHILSRQNQYNITSKRNGVAKVNIFFEQWNHKSNGESPAFTVVTLLSQLGSQWSLWFGSSVLSVVELVELILDFIAITCILAIHWLNMNRSSDLPIPTSNTTDTFHNVLPPPNTLPRASVDPDVITLPSYKSLESLDLRRVSSQQTE

Gene
scnn1a
Protein
Amiloride-sensitive sodium channel subunit alpha
Organism
Xenopus laevis
Length
632 amino acids
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Mass
72.627 kDa
Sequence
MTKEEKNEKEALIEFFSSYRELFEFFCSNTTIHGAIRLVCSRRNRMKTAFWLVLFLVTFGLMYWQFGLLFGQYFSYPVSINLNVNSDKLPFPAVTVCTLNPYRYKAIQNDLQELDKETQRTLYELYKYNSTGVQGWIPNNQRVKRDRAGLPYLLELLPPGSETHRVSRSVIEEELQVKRREWNIGFKLCNETGGDCFYQTYTSGVDAIREWYRFHYINILARVPQEAAIDGEQLENFIFACRFNEESCTKANYSSFHHAIYGNCYTFNQNQSDQSNLWSSSMPGIKNGLTLVLRTEQHDYIPLLSSVAGARVLVHGHKEPAFMDDNGFNIPPGMETSIGMKKETINRLGGKYSDCSEDGSDVDVKNLFQSEYTEQVCVRSCFQAAMVARCGCGYAFYPLSPGDQYCDYNKHKSWGHCYYKLIIEFTSNKLGCFTKCRKPCLVSEYQLTAGYSKWPNRVSQDWVLHTLSRQYNLTDRNGIAKLNIYFEELNYKTILESPTINMAMLLSLLGSQWSLWFGSSVLSVVEMLELVIDFVIIGVMILLHRYYYKKANEGEETTVVPTPAPAFADLEQQVPHIPRGDLSQRQISVVADITPPPAYESLDLRSVGTLSSRSSSMRSNRSYYEENGGRRN