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SCLAV_p0068

Gene
SCLAV_p0068
Protein
(+)-T-muurolol synthase ((2E,6E)-farnesyl diphosphate cyclizing)
Organism
Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
Length
418 amino acids
Function
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) into (+)-T-muurolol via a 1,10-cyclization, which requires isomerization of FPP to nerolidyl diphosphate (NPP) and then abstraction of the pyrophosphate from intermediate NPP leading to a (E,Z)-germacradienyl (helminthogermacradienyl) cation.
Similarity
Belongs to the terpene synthase family.
Mass
46.002 kDa
Sequence
MSLNHSDLMFYCPVDDLPHPAASGVNDRTLDWASGQGIPTADRDAGRLRAMAPGLLAARIAPDARGPVLDAFADHHTWLFAFDDEYCDRADGSGITEWASFLARLHRVVETGESALLPGNPYGLALRDIACRLSTYTTPAQLAEWLEALRSYFAALVWERSRRRDDDRLQSLDDYLLLRLRNGAMHTSITLLDTVNGYVLPRELRETPGVRALVEMTALLVSVDNDILSHHKESTSGTREANLLDVLGRTGHTTPGEAVAQAVALRNEIMRQFVRVAERVRTPAAVPELYRFTTGLARWIRANLDFSLTTTRYTGPVTERAALSPHEVPPLSGQGPAPARSDVIGWWWRIPEPLPEPGSDGADTPVRKRRAGDRPPTAGRGGAPHHQRTGPPPPVLPGGITASRSSGLQQSTWRREHR