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SCARB1

Gene
SCARB1
Protein
Scavenger receptor class B member 1
Organism
Homo sapiens
Length
552 amino acids
Function
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).
Similarity
Belongs to the CD36 family.
Mass
60.878 kDa
Sequence
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS

Gene
SCARB1
Protein
Scavenger receptor class B member 1
Organism
Bos taurus
Length
509 amino acids
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Similarity
Belongs to the CD36 family.
Mass
57.61 kDa
Sequence
MGNLSRARRVTAALGFIGLLFAVLGIIMIVMVPSIIKQQVLKNVRIDPNSLSFNMWKEIPVPFYLSVYFFNIVNPEGIIQGQKPQVQEHGPYVYREFRHKSNITFNNNDTVSFLEYRSYQFQPDKSRGQESDYIVMPNILVLSASMMMENRPGLLKLMMTLAFSTLGQRAFMNRTVGEIMWGYDDPLIHLINQYFPNSLPFKGKFGLFAELNNSDSGLFTVFTGVKNFSRIHLVDKWNGVSKVNYWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFRFVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSGLHPNPKEHSLFLDIHPVTGIPMNCSVKLQLSLFVKSVKGIGQTGNIQPVVLPLMWFEESGAMEGETLETFYIQLVLMPKVLHYAQYVLLALGCVLLLIPIIYQIRSQEKCYLFWISFKKGSKDKEAVQAYSEFLMTSAPKGTVLQEARL

Gene
SCARB1
Protein
Scavenger receptor class B member 1
Organism
Cricetulus griseus
Length
509 amino acids
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Similarity
Belongs to the CD36 family.
Mass
56.735 kDa
Sequence
MGGSARARWVAVGLGVVGLLCAVLGVVMILVMPSLIKQQVLKNVRIDPSSLSFAMWKEIPVPFYLSVYFFEVVNPSEILKGEKPVVRERGPYVYREFRHKANITFNDNDTVSFVEHRSLHFQPDRSHGSESDYIILPNILVLGGAVMMESKSAGLKLMMTLGLATLGQRAFMNRTVGEILWGYEDPFVNFINKYLPDMFPIKGKFGLFVEMNNSDSGLFTVFTGVQNFSKIHLVDRWNGLSKVNYWHSEQCNMINGTSGQMWAPFMTPQSSLEFFSPEACRSMKLTYHDSGVFEGIPTYRFTAPKTLFANGSVYPPNEGFCPCLESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPDPREHSLFLDIHPVTGIPMNCSVKLQISLYIKAVKGIGQTGKIEPVVLPLLWFEQSGAMGGEPLNTFYTQLVLMPQVLQYVQYVLLGLGGLLLLVPVIYQLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL

Gene
Scarb1
Protein
Scavenger receptor class B member 1
Organism
Mus musculus
Length
509 amino acids
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (By similarity). Both isoform 1 and isoform 2 act as receptors for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:9254074, PubMed:9614139). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity).
Similarity
Belongs to the CD36 family.
Mass
56.754 kDa
Sequence
MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIICQLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL

Gene
SCARB1
Protein
Scavenger receptor class B member 1
Organism
Sus scrofa
Length
509 amino acids
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Similarity
Belongs to the CD36 family.
Mass
57.514 kDa
Sequence
MGSRSRARQVAAALGFVGLLLAALGAVMIVMVPSIIKQQVLKNVRIDPSSLSFNMWKEIPVPFYLSVYFFDVINPNEILQGQKPQVRERGPYVYREFRHKSNITFNDNDTVSFLEYRSYQFQPHKSRGLESDYIVIPNILVLSASVMMEDRPMSLKLIMTFAFSALGERAFVNRTVGEIMWGYEDPLIHLINKYFPNMFPFKGKFGLFAELNNSDSGLFTVFTGVKDFSRIHLVDKWNGLSKVNFWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLIYKEQGVFEGIPTFRFVAPNTLFANGSVYPPNEGFCPCMESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSGLHPNTEEHSLFLDIHPVTGIPMNCSVKLQLSLYIKSVKGIGQTGKIEPVVLPLLWFAESGAMEGETLQTFYTQLVLMPKVLHYAQYVLLALGCVLLFIPIVYQIRSQEKCYLFWSSSKKGSKDKEAIQAYSESLMTPAPKGTVLQEARL

Gene
Scarb1
Protein
Scavenger receptor class B member 1
Organism
Rattus norvegicus
Length
509 amino acids
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Similarity
Belongs to the CD36 family.
Mass
56.957 kDa
Sequence
MGVSSRARWVALGLGVLGLLCAALGVIMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPSEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSYIENRSLRFQPDRSQGSESDYIVLPNILVLGGAVMMEDKPTSLKLLMTLGLVTMGQRAFMNRTVGEILWGYEDPFVNFLSKYFPDMFPIKGKFGLFVGMNDSSSGVFTVFTGVQNFSKIHLVDKWNGLSEVNYWHSEQCNMINGTAGQMWAPFMTPESSLEFFSPEACRSMKLTYQESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSQPHFYNADPVLSEAVLGLNPDPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGVGQTGKIEPVVLPLLWFEQSGMMGGKTLNTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIIYQLRSQEKCFLFWSGSKKGSQDKEAMQAYSESLMSPAAKGTVLQEAKL