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SCARA5

Gene
scara5
Protein
Scavenger receptor class A member 5
Organism
Danio rerio
Length
499 amino acids
Function
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.
Similarity
Belongs to the SCARA5 family.
Mass
55.221 kDa
Sequence
MENRAMYLTTTHEDRENSSFYEESYDGMNLSKLNLCEEVNSTKYRRKTDNRCGQLDSLTSIKYAIVSLYILVLLTIFGLCIAVSKSHASWRREEALLENVTRLGEQSETLQMSLSQIPSQSDLLENIWKLESLFHNHTEQLRLLGLLTQGLERDIKDLQAFAEHTTDSVAQLWDHLSMISHSSQRNSTHLGDELASTAGSIREQDALLKTMVGNVETLQERLEDMGWTLQTLNHSLGGDVSLHQIKIYELQEKIVNVTHDTLGMKITQTHLEDQLRNEIQVLNVVTADLRLKEWEHSMALKNLTIFQGPPGPKGEKGDVGPLGPDGIPGWIGPRGLTGEKGVQGPRGLAGRNGQDGHNGDKGEVGPEGPKGVRGERGPKGEKGERGDKQGEKVEDAVVRLVNGSGPHEGRVEVLHDLRWGTVCDDVWDIKDGDVVCRMLGFRGAKEIHKTGRFGQGTGLIWMDDVACVGTEDSIDLCKFSGWGKTNCGHVEDAGVTCNV

Gene
SCARA5
Protein
Scavenger receptor class A member 5
Organism
Bos taurus
Length
495 amino acids
Function
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
Similarity
Belongs to the SCARA5 family.
Mass
53.453 kDa
Sequence
MENKAMYLHATVSDRDSSSIFEEPFDGRSLSKLNLCEDGPCHKGRAGGCCTQLGSLSALKHAVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLNESFRDLQLRLLQAPLQGELSEQVWKAHDALQNQSDSLLALAGAVQRLEGALWGLQAQAAQSEQAVVLLRERAAQQSDAAQLELYQLQVDSNRSQLLLRRHAGLLDGLARRVGALSDELADVGGALRGLNLSLSYDVALQGTRLRDLRVLVSNASEDARRLRLAHRGLELQLKQELAVLNGVTEDLRLKDWEHSIALRNITLAKGPPGPKGDPGDAGKEGEPGIPGLPGLRGLPGERGTPGLPGPKGDEGKLGATGPMGMRGFKGDRGPKGEKGEKGDRTVDASGVEAVMVRLVNGSGLHQGRVEVYHERRWGTVCDDGWDKKDGDVVCRMLGFPGAEDVHRTAQFGQGTGRIWMDDVACKGTEESIFRCSFSKWGVTNCGHAEDAGVTCKRH

Gene
SCARA5
Protein
Scavenger receptor class A member 5
Organism
Homo sapiens
Length
495 amino acids
Function
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
Similarity
Belongs to the SCARA5 family.
Mass
53.994 kDa
Sequence
MENKAMYLHTVSDCDTSSICEDSFDGRSLSKLNLCEDGPCHKRRASICCTQLGSLSALKHAVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLNESFRDLQLRLLQAPLQADLTEQVWKVQDALQNQSDSLLALAGAVQRLEGALWGLQAQAVQTEQAVALLRDRTGQQSDTAQLELYQLQVESNSSQLLLRRHAGLLDGLARRVGILGEELADVGGVLRGLNHSLSYDVALHRTRLQDLRVLVSNASEDTRRLRLAHVGMELQLKQELAMLNAVTEDLRLKDWEHSIALRNISLAKGPPGPKGDQGDEGKEGRPGIPGLPGLRGLPGERGTPGLPGPKGDDGKLGATGPMGMRGFKGDRGPKGEKGEKGDRAGDASGVEAPMMIRLVNGSGPHEGRVEVYHDRRWGTVCDDGWDKKDGDVVCRMLGFRGVEEVYRTARFGQGTGRIWMDDVACKGTEETIFRCSFSKWGVTNCGHAEDASVTCNRH

Gene
Scara5
Protein
Scavenger receptor class A member 5
Organism
Mus musculus
Length
491 amino acids
Function
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
Similarity
Belongs to the SCARA5 family.
Mass
53.667 kDa
Sequence
MDNKAMYLHTVSDRDNGSIFEEPFDGRSLSKLNLCEDGPCHKRRAGGCCTQLGSLSALKHAVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLNESLRDMQLRLLQAPLQADLTEQVWKVQDALQNQTDSLLALAGLVQRLEGTLWGLHAQAAQTEQAMALLRDRTGQQSDSAQLELYQLQVESNRSQLLLQRHAGLLDGLARRVGVLGEELADVGGALRGLNHSLSYDVALHSTWLQDLQVLVSNASADTRRMRLVHMDMEMQLKQELATLNVVTEDLRLKDWEHSIALRNITLAKGPPGPKGDQGNEGKEGKPGSPGLPGSRGLPGERGDPGLPGPKGDDGKLGATGPMGMRGFKGDRGPKGEKGERGERAGDMDFTMIRLVNGSGPHQGRVEVFHDRRWGTVCDDGWDKKDGDVVCRMLGFHGVEEVYRTARFGQGTGRIWMDDVNCKGTESSIFHCQFSKWGVTNCGHAEDAGVTCTVP