Function
(2Z,6Z)-farnesyl diphosphate cyclizing enzyme. Produces (+)-alpha-santalene, (+)-endo-beta-bergamotene, (-)-endo-alpha-bergamotene, and at lower amounts, (-)exo-alpha-bergamotene and (+)-epi-beta-santalene. Not able to use geranyl diphosphate, E,E-farnesyl diphosphate or E,E,E-geranylgeranyl diphosphate as substrates, but able to use Neryl diphosphate to make the monoterpene terpineol.
Sequence
MIVGYRSTIITLSHPKLGNGKTISSNAIFQRSCRVRCSHSTPSSMNGFEDARDRIRESFGKVELSPSSYDTAWVAMVPSKHSLNEPCFPQCLDWIIENQREDGSWGLNPSHPLLLKDSLSSTLACLLALTKWRVGDEQIKRGLGFIETQSWAIDNKDQISPLGFEIIFPSMIKSAEKLNLNLAINKRDSTIKRALQNEFTRNIEYMSEGVGELCDWKEIIKLHQRQNGSLFDSPATTAAALIYHQHDKKCYEYLNSILQQHKNWVPTMYPTKIHSLLCLVDTLQNLGVHRHFKSEIKKALDEIYRLWQQKNEQIFSNVTHCAMAFRLLRMSYYDVSSDELAEFVDEEHFFAISGKYTSHVEILELHKASQLAIDHEKDDILDKINNWTRTFMEQKLLNNGFIDRMSKKEVELALRKFYTISDLAENRRCIKSYEENNFKILKAAYRSPNIYNKDLFIFSIRNFELCQAQHQEELQQFKRWFEDYRLDQLGIAERYIHDTYLCAVIVVPEPELSDARLLYAKYVLLLTIVDDQFDSFASTDECLNIIELVERWDDYASVGYKSEKVKVFFSTLYKSIEELVTIAEIKQGRSVKNHLLNLWLELVKLMLMERVEWFSGKTIPSIEEYLYVTSITFGARLIPLTTQYFLGIKISEDILESDEIYGLCNCTGRVLRILNDLQDSKKEQKEDSVTIVTLLMKSMSEEEAIMKIKEILEMNRRELLKMVLVQKKGSQLPQICKDIFWRTSNWADFIYLQTDGYRIAEEMKNHIDEVFYKPLNH