Sae1

SUMO-activating enzyme subunit 1

350 amino acids

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

38.62 kDa

MVEKEEAGGGGGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDPGAQFLIQTGSVGRNRAEASLERAQNLNPMVDVKVDTEDVEKKPESFFTKFDAVCLTCCSRDVIIKVDQICHRNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPEAKRAKLDSSETTMVKKKVLFCPVKEALEVDWSGEKAKAALKRTAPDYFLLQVLLKFRTDKGRDPTSESYKEDAELLLQIRNDVFDSLGISPDLLPDDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGSGIVECLGPQ

Sae1

SUMO-activating enzyme subunit 1

349 amino acids

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

38.513 kDa

MVEKEEVSGGGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDLGAQFLIRTGSVGQNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTEFDAVCLTCCSKDVIIKVDQICHRNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVTKVSQGVEDGPDAKRAKLDSSETTMVKKKVLFCPVKEALAVDWSGEKAQAALKRTAPDYFLLQVLLKFRTDKGRDPTSDSYSEDAELLLQIRNDVFDSLGVSPDLLPDDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGSGIVECLGPQ

sae1

SUMO-activating enzyme subunit 1

348 amino acids

The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

39.076 kDa

MIDTIEKEDTIISEEEAAQYDRQIRLWGLDAQKRLRGSRVLLVGLRGLGAEVAKNLILAGVKGLTLLDHEQVTEESRRAQFLIPVDADGQNHAQASLERAQFLNPMVEVKADTEPVESKPDDFFFQFDAVCLTRCSRDLMVRVDQLCASRNIKVFCGDVYGYNGYMFSDLGQEYHYVEEKPKVVKGSNEANDGPEAKKPKIDPNETTMVKKTISFCSLKEALEVDWTTEKAKSSLKRIPADYFLLQVLLKFRTDKGRDPQPDSFAEDSQLLLQIRDDVLETMGLSSDLLPNTFVSYCFSEMSPVCAVVGGVLGQEIVKALSQRDAPHRNFFFFDGLKGSGVVDYFSSK

sae1

SUMO-activating enzyme subunit 1

347 amino acids

The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

38.776 kDa

MVEKEEAVISEEEAAQYDRQIRLWGLEAQKRLRTSRVLLVGMRGLGAEVAKNLILAGVKALTLLDHEQVSSEDSRAQFLIPSGSLGQNRAEASLNRARNLNPMVSVEADTENINQKSDDFFTQFDVVCLTSCSRDLLVRVDHICHKHNIKFFTGDVFGYHGYMFADLGEHEFVEEKAKVAKVSKAKQEVEDGPEAKKAKIDPTESILVKKKVQFCPLKDALEIDWHSEKAKSALKKTPTDFFLLQVLMKFRTDKKRDPQPSNYQEDSELLLQICSDVLDSLGVSPDLLPKDFASYCFSEMAPVCAVVGGVLGQEIVKALSQRDAPHNNFFFFDGRSSNGIVDCLGSK

SAE1

SUMO-activating enzyme subunit 1

346 amino acids

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

38.306 kDa

MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASQVLLVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTENIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCSVKEALEVDWSSDKAKAALKRTTPDYFLLQVLLKFRTDKGRDPSSDTFGEDSELLLQIRNDVLDALGVNPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPN

SAE1

SUMO-activating enzyme subunit 1

346 amino acids

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Belongs to the ubiquitin-activating E1 family.

38.45 kDa

MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK

SAE1

SUMO-activating enzyme subunit 1

346 amino acids

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

38.45 kDa

MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK

sae1

SUMO-activating enzyme subunit 1

344 amino acids

The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

38.247 kDa

MVEKEEAVISEEEAAQYDRQIRLWGLEAQKRLRTSRVLLVGMRGLGAEVAKNLILAGVKALTLLDHEQVSSEDSRAQFLIPSGSLGQNRAEASLNRARNLNPMVSVEADTENINQKSDDFFTQFDVVCLTSCPSDLLVRVNHICHKHNIKFFTGDVYGYHGSMFADLGEHEFVEEKAKVTKAKPLVEDGPEAKKAKIDPTETILVKKKVQFCPLKDALEIDWRSEKAKSALKKTPTDYFLLQVLMKFRTDKGRDPQPSSYQEDSELLLQICSDVLDSLGVSPDLLPKDFASYCFSEMAPVCAVVGGVLGQEIVKALSLRDAPHNNFFFFDGKTSNGIVDCLGSK

sae1

SUMO-activating enzyme subunit 1

330 amino acids

The dimeric enzyme acts as an E1 ligase for sumo. It mediates ATP-dependent activation of sumo and formation of a thioester with a conserved cysteine residue on sae2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

37.227 kDa

MTNPENTPMTTTNEGGKGLTEYEAKIYDRSIRLWGVDAQAKLRQSKVLFIGINGLMSEIIKNVVLAGVDSITLVDDHIITTSDLSAHLFINEDSVGKVISTESVFAISELNPLVTIDVYDKEIETMDDQFIKNYTMVVISDKNLNNVSKVNSLCRKNNVSFIFSHSFGLKGLFFSDLNEFKYFTKTTTEPPKTETHISIFKSFKESMGYDWSKTNSRTPLPFFALSTLYQFEEKHNRVPDNISDSDLSELKSIINSSIEKFNLKNTDSNKYFEETKDLLNKMNIEISPVCAIVGGIVGAEIIKIITQNMQVLNNFFFYDGVKGTGLVEQF