RMI1

RecQ-mediated genome instability protein 1

817 amino acids

Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells.

Belongs to the RMI1 family.

88.117 kDa

MRRRNLIITSDSDSDDGGGGGGAATASTPASASASASFPSVSGGGCGDGWPSPQNPRSVPVQFPSPSSPPPSPPIEISDEEEAEAEVVVEEEEVVVVEDEEEEYEEVEEIEDPDGDSPFVDAPEHISPPPPPPPPARTPMPTPTPTPTPTPTRPPVPVWAAPLPARTPTPTPSAPPRAAAPSPAGTPSPSPIPPSSTPVSALSGPLRQVDEFLRGLGLRLRPEWLESCAAGVPGFYGLGGVEAMARRCFEQFLFADMNACGAGVLPEGVGSMHNAVLDGPLVLQVDEIVNLSAPLRERYRDAHAGPKRCLKLSMTDGIQRIYGMEYRPIKDLEVLAPAGFKIVIRNVHIRRGLFMLVPEVIEILGGVDDELDEARNRLVSEVNKPPRGKRKQGGLPLSSRATLAAWPTNANATNDAEQGASVPRTVNTPHPTRLGNASHASQVGRTTQPMVDNLIPHVVVSNAQEQSRHIQEITMQGQPTSLNRHNKEASASYRYNAQCSISGTTRAMADEHVLVSNAQEQSPHIQEITMQDQSTSLNGRNKEASASTSYRYNAQCSISGTTRAMADERVDPSFVGNNVHEQMQRVQGITMQDHISASSESKRELSVTTPSGYDSRLAPHGVGNTGTRSGEATRSSNVDDGINNIGHPISLCGENEKPFTYIFNMLADWGVQQDTVPYIQGKIKGLITSVKRFQYKQSMQYDLYVYIDDGSFITEAFVDRDIVQNMIGLSAEELAAALSSGGPAQANIRKTMKAFEHFLVNFEGTILIELNRDSSVPIVREMNKGCSSSDAWQLLRRVKTFSGQGYMRSLDFMDTTP

RMI1

RecQ-mediated genome instability protein 1

644 amino acids

Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells. Together with TOP3A, is essential for the resolution of meiotic recombination intermediates, a step that prevents entanglement of the parental chromosomes.

Belongs to the RMI1 family.

69.97 kDa

MRRRRLQLRYSSDEEEEDETGTSGVGDSVQSFGIASSIQPETSVSSNSNPNPGERIAISEVEIIDVFGNPQPTPPDSSIPTPYPVYPSESVSGNDYESPISEVLSRMGIKLKREWWVSCLSGLETSIPQFSYLDVAAKAKHCFEQFMFFDMNLCGGGVLPPNVASMNRIELAGPFVLQVDEIVNIGCPLKGRYENANAGLKRCLKLSMTDGVQRVFGMEYRPIKDLQVLAPAGLKIVVSSVQVRHGLLMLVPEIVEVLGGMVEELEEARKRLVVEVNKPPRGKRTRVGVVPSLTTRATLAAWSLNGNDTGNHVHDTGNHVNSSASGNASHTQANQGIPVHVTRTHNSSRAMDEPLASTNVGATVSRVEHMQIDTASAHGERTFSDIHSTSSNIHRAASTAGTGTSCSGACSGARSFANNVGGNSLDQTSNVTSFVEEMHIDTGRVRDTTTHIYGSDSGGVAAEFSNMVVDLEGPSVLSTNTEKPFTYLAELSQKWAVMKDTIHFVQGRIKCFLTGVKKFQFKQQSTYELLCYVDDGSLICEILLHNDVVQKRIGHSSMEVTAALSSSAPTSLNAMMKEKLKRFQLFLADFEGIMVVEMNRSSQYPVAIEMNQGCSLTDARLLLDRIKSSSRTSSSLNPVVVLSP

RMI1

RecQ-mediated genome instability protein 1

627 amino acids

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).

Belongs to the RMI1 family.

69.236 kDa

MSTPNVTARVETWLSSTWHVKVPLTWLEACINWIQEENGGGNLSQAQISRQVFEQWLLTDLRDLEYPILPDGILDAPKGELSGFYSLQIDSLLDVSQPAYSQLQKIRGKSTVNEEVTANTQAFQKPWEAKPTRMLMLQLTDGIHQIQGMEYQPVPVLHSNLPPGTKITVHGNVAYRLGVLLLKPENVKLLGGEVDALLEEYSQERVLARLLGEAENPDSVRQPGHEQIVPGPVDELGQTLGPSDEELLASLDENNDFILNNETSLESGYCSRSNNFSATSCSLTTYNENTTGFPLQQESVNLLPRSDEQTPPSVEYNDAFLNDFPLEDDILLEEEIQRELEEVPSVARNGNVNLSTERIPHTYRSSCGSSLNETSEKDDGCGSEKPVEVTSKQKNLARTVSTGDGTSTGGSLQCNSVSQACSSAIVLLKNPHEERRNDLGPDESSCQSRHAPDSRQLNKDPVSSSKTDPEADQQAILCRPGNACDLDLDSPPFTYISLLLAKKPETITLVKVKCFIVTLTGNLTSSNGSWGIKAKVSDGSAYLEVDFADDILTSLIGFSVPEMHTLRKDPALQPKLKDGLERCQKQLIDLCCLMTIEFNPFQSKATVLILQDTDARHLEQLKKRLNK

RMI1

RecQ-mediated genome instability protein 1

625 amino acids

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.

Belongs to the RMI1 family.

70.144 kDa

MNVTSIALRAETWLLAAWHVKVPPMWLEACINWIQEENNNVNLSQAQMNKQVFEQWLLTDLRDLEHPLLPDGILEIPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVTAEAQVTPKPWEAKPSRMLMLQLTDGIVQIQGMEYQPIPILHSDLPPGTKILIYGNISFRLGVLLLKPENVKVLGGEVDALLEEYAQEKVLARLIGEPDLVVSVIPNNSNENIPRVTDVLDPALGPSDEELLASLDENDELTANNDTSSERCFTTGSSSNTIPTRQSSFEPEFVISPRPKEEPSNLSIHVMDGELDDFSLEEALLLEETVQKEQMETKELQPLTFNRNADRSIERFSHNPNTTNNFSLTCKNGNNNWSEKNVSEQMTNEDKSFGCPSVRDQNRSIFSVHCNVPLAHDFTNKEKNLETDNKIKQTSSSDSHSLNNKILNREVVNYVQKRNSQISNENDCNLQSCSLRSSENSINLSIAMDLYSPPFVYLSVLMASKPKEVTTVKVKAFIVTLTGNLSSSGGIWSITAKVSDGTAYLDVDFVDEILTSLIGFSVPEMKQSKKDPLQYQKFLEGLQKCQRDLIDLCCLMTISFNPSLSKAMVLALQDVNMEHLENLKKRLNK

RMI1

RecQ-mediated genome instability protein 1

624 amino acids

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).

Belongs to the RMI1 family.

70.051 kDa

MSVTSIALRVETWLSATWHVKVPVTWLEACINWIQEENDHVNLSQAQMNKQVFEQWLLTDLRDLEHRLLPSGILETPKGELNGFFALQINSLVDVSQPAYAQIQKLRGKNTTNDLITAETQVTPKPWEAKPSRMLMLQLTDGIVQIQGMEYQSIPALHSDLPPGTKILIYGNISFRLGVLLLKPENVKMLGGEVDALLEEYAQEKVLARLIGEPDPIVSVIPNNSNQIIPRITDVLDPALGPSDEELLASLDENDELAANNNTSLERSCFIGNSSNTVPIRQSDFETELVISPRPREKPRNQSMLFTDEELDDFSLEEALLLEEAVQKEQMETKELQLLTLNRTTDESIEKFSHRSNTLNNFSFICKNGNNNWSEKNLSEQMTSEDKSLSCPSTRDQNSSSLSVNHNVPLPHDFTNKGKSSETYKIKQISSSDGHSLNNKMFNGELVSNVPKRSSDVPNENEHHLQTCSLQLSENSTGLPITMDLYSPPFIYLSVLMASKPKEVTTVKVKAFIVTLTGNLSSSGGIWSVRAKISDGTAYLDVDFVDEILTSLIGFSVSEMKRLKKDPCKYQKFLEGLQKCQRELIDLCCLMTISFNPSLSKAMVLALQDVNTDHLENLKRRLKK

Rmi1

RecQ-mediated genome instability protein 1

616 amino acids

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).

Belongs to the RMI1 family.

68.465 kDa

MSVASAVLRVETWLLATWHVKVPPMWLEACVNWIQEENNNATLSQAQINKQVLEQWLLTDLRDLEHPLLPDDILELPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVSAETQSTPKPWEVRPSRMLMLQLTDGVTHIQGMEYQSIPALHSGLPPGTKILVRGCILFRLGVLLLKPENVKVLGGEVDGLSEENAQEKVLARLIGELDPTVPVIPNNSIHNVPKVSGGLDAVLGPSDEELLASLDESEESAANNDVAMERSCFSTGTSSNTTPTNPSGFEPGCNISSRPKEKPPNQPTHFTDGEFDDFSLEEALLLEETVQKEQMETKASQPLTLKENTGKCMEIFSHKPSSLNHTALIHKQGNSNFDEKTSEQMIHEDKFFDCASTRNHHKRFSAHDFTNDSKISEVDDAAQQTLSSSNVHCLRNKILNRKLDLSEKSSQISKENGHPFQACSSRSFENNTYLSIGMDLHSPPFIYLSVLMARKPKEVTTVTVKAFIVTLTGNLSSSGGFWGVTAKVSDGTAYLDVDFIDEILTSMIGYSVPEMKQLRKDPLKYKTFLEGLQKCQRDLIDLCCLMTISYDPSSCKGVVLELQDVGMEHVENLKKRLNK

rmi1

RecQ-mediated genome instability protein 1

557 amino acids

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).

Belongs to the RMI1 family.

61.68 kDa

MMATSGIANRVKTWLISTWHVKVPDPWLEACINWIQEENGSSLLQAEINKQVFEQWLLTDLRDLEFPVLPANITDSLKCELNGFHAVQMDSLVDISLPAYSQLQKLKGKDSTNEQVTCTTQQSQKPWEAKPTRMLMLQLTDGTQHIQAMEYRPIQALNANLSPGTKMVLQGTIVCRLGVLLLKPENVKVLGGEVEALVAEYTQTKVLSRLIGVEDNTVAQHSNVQEHAAGVAAGELGQALGPSDEDLLASLEENEEFSINNGVPSESGYYSRNENSSISSSTQHQTQDSIVRCWVDDDILEFSINNGVPSESGYYSRNENSSISSSTQHQTQDSIVRQTSFPMLDQTVVHVNVANNHAIEEQFDIDDELFLEEEIQRELEEMSMSQAEVTHGSTDLPTTLSATSHASSASCTSDQNNIDIPPYTYLSTILASKSRSITCVKLKSFIVTLNGNLSHSCGLWNIKAKISDGTGYLNVEFSDDVLTELIGFTVPEMKTLKKDPSQQSTLMEGLQKCQRMLTDFCGVMTVSYNPAKEEAVVLSLQDVTEEIMQSLQKLLRS

rmi1

RecQ-mediated genome instability protein 1

519 amino acids

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).

Belongs to the RMI1 family.

57.581 kDa

MSVGEVQVIQAWLRSEWHIQVPPAWLDACVNWIKEEADRASIPQSQLNQRVLEQWLLTDLRDLAHPVLPERISEAQKTVLSNRCCVQMDSLLDVSQPAYNQLQRIRGTDCSNDQVSAVTQETQRPWEAKPTRMLMLQLTDGVQNLEGMEYRPIPALNANLPPGTKLQLVGPIAVRLGVLLLKAENIKVLGGEVEQLLEIHSQSRVLCGTLGLPEETHPQQEPDGLVASVADSGYSSLASEASLRHPQSQPLPQISRQDDWDMDEIPDDDFRSIPDHFDDLPQNNNPLEDVPEDFDDIPLDELDNVMCPIDVEVSAGTLEDPERNKHDSSLLNGSKPEEVSFPSRSRLGNTYQSRTLNKVPNTSLASCSTSTLDSSACKETPMYLCSLQAGCWPPKSPQVFRLQAFIVTLVGNLRISGGVWKLGATISDGSGYLDVDLSDNMLSELIGFSAAETRVLRKDLARRGEVDSGIQHCQRELVDMCCMMSVQVDLTGRGVVLSASPISDRECSEMQKRVKEARR

RMI1

RecQ-mediated genome instability protein 1

241 amino acids

Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with SGS1 and TOP3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response. Required for resistance to the DNA-damaging agent methyl methanesulfonate (MMS).

Belongs to the RMI1 family.

26.86 kDa

MSFSSILSQDITDDITPPAYSATLGSREQIVFRAYQNEPWLAGTASNLILDKKLVIVDRELLFQVLMVENITKSKLTQIDDIKTKLDPKKQKVDRLRSGAQGNGAKKYEVITQVDMEDDGNVADNNCAKENNSNNNSSAAKNKAVFKLTLQSKSGDVFFAINSTPISWSSCMLGSKIVILPGTVFNRGVFILKDSQVIFLGGINRVWNENRDQKFCDYLESKLQRDKQLVNGGSKKRKAND

rmi1

RecQ-mediated genome instability protein 1

235 amino acids

Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with top3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response.

Belongs to the RMI1 family.

26.632 kDa

MNQTTTLSTELTELGVRVQNRWLQSLLDYLAKKHSTGANTTPQLVMQYLVASDIRESTTSEGAAPYIVSEQHNVRIENTMLLQIVRVREIGISIVNQLEYLNDLEELKKLKGQKVIRLVHDESGDEEQNDDDGLTEAQDAVQKGSELKKMCRLILEDSNGQRFWGLERKPIKGIQLSTKLGTKLLVKNVLVRRGVLMLDPNNTTILGGSIEEWDKDYFPKRLIEELKGELSKTKA