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RfC4

Gene
Rfc4
Protein
Replication factor C subunit 4
Organism
Mus musculus
Length
364 amino acids
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity).
Similarity
Belongs to the activator 1 small subunits family.
Mass
39.867 kDa
Sequence
MQAFLKGTSVSAKAQLTKDRGTPATAGSSGETKKVKPVPWVEKYRPKCVDEVAFQDEVVAVLRKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQERLLDIAEKENVKIGNEEIAYLVKISEGDLRKAITFLQSATRLTGGKEVSEDVITDIAGVIPAATIDGIFTACHSGSFDKLEAVVKNLIDEGHAATQLVNQLHDAIIENENLSDKHKSIITEKLAEVDKCLADGADEHLQLMSLCATVMQQLTQNC

Gene
RFC4
Protein
Replication factor C subunit 4
Organism
Homo sapiens
Length
363 amino acids
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.
Similarity
Belongs to the activator 1 small subunits family.
Mass
39.682 kDa
Sequence
MQAFLKGTSISTKPPLTKDRGVAASAGSSGENKKAKPVPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRLLDIAKKENVKISDEGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEKVITDIAGVIPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAATQLVNQLHDVVVENNLSDKQKSIITEKLAEVDKCLADGADEHLQLISLCATVMQQLSQNC

Gene
rfc4
Protein
Probable replication factor C subunit 4
Organism
Dictyostelium discoideum
Length
347 amino acids
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity).
Similarity
Belongs to the activator 1 small subunits family.
Mass
38.855 kDa
Sequence
MSKIQKKDTEPWVAKYRPKTVDDVSYQEDVISALKKSLNTGNLPHLLFYGPPGTGKTSTILAIAMDIYGPELMKQRVLELNASDERGIEVVRTKIKNFAGYAVNKTTTGTSNPGATFKLIILDEADSMTTDAQAALRRTIETTSKTTRFCLLCNYISRIIDPLASRCAKFRFKPLDTVATIERLKFISQQEGIKCEESVYQAIQVVSNGDMRKAITYLQSAFRFFANKISEDVIYNIAGSLPPQLIKQLVDCCKKNSFDRLQSMVQSIIAQGYPVSQVISQLFDYVLTTKDLNQSQKSHITMKIGNVDRNLIDGSEEFLQLFDLSSYIMKQLNNNSTSTNGDDMLIG

Gene
rfc4
Protein
Replication factor C subunit 4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
342 amino acids
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1.
Similarity
Belongs to the activator 1 small subunits family.
Mass
37.655 kDa
Sequence
MSNAVSSSVFGEKNNSVAYELPWVEKYRPIVLDDIVGNEETIDRLKVIAKEGNMPHLVISGMPGIGKTTSILCLAHALLGPAYKEGVLELNASDERGIDVVRNRIKAFAQKKVILPPGRHKIIILDEADSMTAGAQQALRRTMEIYSNTTRFALACNQSNKIIEPIQSRCAILRYSRLTDQQVLQRLLNICKAEKVNYTDDGLAALIMTAEGDMRQAVNNLQSTVAGFGLVNGENVFRVADQPSPVAIHAMLTACQSGNIDVALEKLQGIWDLGFSAVDIVTNMFRVVKTMDSIPEFSRLEMLKEIGQTHMIILEGVQTLLQLSGLVCRLAKSQMKPESFII

Gene
RFC4
Protein
Replication factor C subunit 4
Organism
Arabidopsis thaliana
Length
339 amino acids
Function
May be involved in DNA replication and thus regulate cell proliferation.
Similarity
Belongs to the activator 1 small subunits family.
Mass
37.508 kDa
Sequence
MAPVLQSSQPWVEKYRPKQVKDVAHQEEVVRVLTNTLQTADCPHMLFYGPPGTGKTTTALAIAHQLFGPELYKSRVLELNASDDRGINVVRTKIKDFAAVAVGSNHRQSGYPCPSFKIIILDEADSMTEDAQNALRRTMETYSKVTRFFFICNYISRIIEPLASRCAKFRFKPLSEEVMSNRILHICNEEGLSLDGEALSTLSSISQGDLRRAITYLQSATRLFGSTITSTDLLNVSGVVPLEVVNKLFTACKSGDFDIANKEVDNIVAEGYPASQIINQLFDIVAEADSDITDMQKAKICKCLAETDKRLVDGADEYLQLLDVASSTICALSEMAQDF

Gene
RFC4
Protein
Replication factor C subunit 4
Organism
Oryza sativa subsp. japonica
Length
335 amino acids
Function
May be involved in DNA replication and thus regulate cell proliferation.
Similarity
Belongs to the activator 1 small subunits family.
Mass
36.916 kDa
Sequence
MDASSSSAPDLADAYDIPWVEKYRPTRVADVGGNSDAVARLQDIARDGNMPNLILSGPPGTGKTTSILSLAHELLGPSYREAVLELNASDDRGLDVVRNKIKMFAQKKVTLQPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQSRCAIVRFSRLSDQEILGRLMIVVAAEKVPYVPEGLEAIIFTADGDMRQALNNLQATVSGFRFVNQENVFKVCDQPHPLHVKNMVKNVLDGKFDEACSALKQLYDLGYSPTDIITTLFRVIKNYDMAEYLKLELLKETGFAHMRICDGVGSFLQLSGLLAKFALVRETAKAS

Gene
RfC4
Protein
Replication factor C subunit 2
Organism
Drosophila melanogaster
Length
331 amino acids
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP.
Similarity
Belongs to the activator 1 small subunits family.
Mass
37.173 kDa
Sequence
MPEEPEKTADDKRSHLPWIEKYRPVKFKEIVGNEDTVARLSVFATQGNAPNIIIAGPPGVGKTTTIQCLARILLGDSYKEAVLELNASNERGIDVVRNKIKMFAQQKVTLPRGRHKIVILDEADSMTEGAQQALRRTMEIYSSTTRFALACNTSEKIIEPIQSRCAMLRFTKLSDAQVLAKLIEVAKWEKLNYTEDGLEAIVFTAQGDMRQGLNNLQSTAQGFGDITAENVFKVCDEPHPKLLEEMIHHCAANDIHKAYKILAKLWKLGYSPEDIIANIFRVCKRINIDEHLKLDFIREIGITHMKIIDGINSLLQLTALLAKLCIAAEKH

Gene
RFC4
Protein
Replication factor C subunit 4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
323 amino acids
Function
Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair.
Similarity
Belongs to the activator 1 small subunits family.
Mass
36.149 kDa
Sequence
MSKTLSLQLPWVEKYRPQVLSDIVGNKETIDRLQQIAKDGNMPHMIISGMPGIGKTTSVHCLAHELLGRSYADGVLELNASDDRGIDVVRNQIKHFAQKKLHLPPGKHKIVILDEADSMTAGAQQALRRTMELYSNSTRFAFACNQSNKIIEPLQSRCAILRYSKLSDEDVLKRLLQIIKLEDVKYTNDGLEAIIFTAEGDMRQAINNLQSTVAGHGLVNADNVFKIVDSPHPLIVKKMLLASNLEDSIQILRTDLWKKGYSSIDIVTTSFRVTKNLAQVKESVRLEMIKEIGLTHMRILEGVGTYLQLASMLAKIHKLNNKA

Gene
RFC4
Protein
Replication factor C subunit 4
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
309 amino acids
Function
Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment (By similarity).
Similarity
Belongs to the activator 1 small subunits family.
Mass
35.31 kDa
Sequence
MDLLVNKYQPSEIQDIVGNEATMELVSLMIESRDMPHLLFTGPPGTGKTTCAKILARRLLGNKEGLLELNASDERGIDTVRTTIKSFAQRRVKDCEFKIIILDEADSMTTTAQQAMRRVMEIHSSECRFILICNVFTKIFEPIQSRCAILRFDRIEQSVILKRLKEISEGEGIRITAEALDLVVELSDGDMRQSLNILQACINSPGTVDQDYIIKIIGLPSPKRIEKVLQRLLKREVEEALEMFDEIWEEKFDPLDLINSFFRAAKNMESYELLKVIGLANLRISEGVNSRLQFYGMFWDILDMGSKRL