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Rangap1

Gene
Rangap1
Protein
Ran GTPase-activating protein 1
Organism
Mus musculus
Length
589 amino acids
Function
GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:18305100). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (By similarity). Required for postimplantation embryonic development (PubMed:8314081).
Similarity
Belongs to the RNA1 family.
Mass
63.531 kDa
Sequence
MASEDIAKLAETLAKTQVAGGQLSFKGKGLKLNTAEDAKDVIKEIEEFDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVADKAELEKLDLNGNALGEEGCEQLQEVMDSFNMAKVLASLSDDEGEDEDEEEEGEEDDEEEEDEEDEEDDDEEEEEQEEEEEPPQRGSGEEPATPSRKILDPNSGEPAPVLSSPTPTDLSTFLSFPSPEKLLRLGPKVSVLIVQQTDTSDPEKVVSAFLKVASVFRDDASVKTAVLDAIDALMKKAFSCSSFNSNTFLTRLLIHMGLLKSEDKIKAIPSLHGPLMVLNHVVRQDYFPKALAPLLLAFVTKPNGALETCSFARHNLLQTLYNI

Gene
RANGAP1
Protein
Ran GTPase-activating protein 1
Organism
Homo sapiens
Length
587 amino acids
Function
GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).
Similarity
Belongs to the RNA1 family.
Mass
63.542 kDa
Sequence
MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRMAVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFARHSLLQTLYKV

Gene
rangap1
Protein
Ran GTPase-activating protein 1
Organism
Xenopus laevis
Length
580 amino acids
Function
GTPase activator for RAN, converting it to the GDP-bound state (PubMed:9108047). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is required for RAN-mediated nuclear import and export (By similarity).
Similarity
Belongs to the RNA1 family.
Mass
62.908 kDa
Sequence
MAAEDIAQLADCLAKANVGDGELSFKGKTLKLNTAQDAEEVIREIEEYEGLQALRLEGNTVGVEAAKAIAEVLQRKPDLKRCHWSDMFTGRLRPEIPTALRSLGDALITAGAQLTELDLSDNAFGPDGVRGFEALLKSPTCFTLQELKLNNCGMGIGGGKILAAALTECHKKSSAHGKPLALKVFIAGRNRLENDGATALSEAFRLIGTLEEVHMPQNGINHAGITALAESFKANSLLKVINLNDNTFTEKGGVAMAEALKTLRQVEVINFGDCLVRSKGAQAIASALKEGLHKLKDLNLSYCEIKADAAVSLAESVEDKSDLEKLDLNGNCLGEEGCEQVQEILESINMANILGSLSDDEDEDDDDDDEDDDDDEDDENDDEEVEEEEEEVEEEEGGDNENKEKSKEIPCLSGSAPASPPKLPVDASTFLSFPSPEKLVRMGPRRSAMIAQQVNVADTEKVVQAFIQVSSVYREDGEIKAAVEETIDGLMKEAFENRGFQANVFITSLLVQMGLLKSEDKMKTIPHLNGPLLTLNHMVQQNYFPKSLASTLLAFISKPNGVLENNASARHTLLCNLHNL

Gene
RANGAP1
Protein
RAN GTPase-activating protein 1
Organism
Arabidopsis thaliana
Length
535 amino acids
Function
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Plays a role in spatial signaling during cell division.
Similarity
Belongs to the RNA1 family.
Mass
58.827 kDa
Sequence
MDHSAKTTQNRVLSVKMWPPSKSTRLMLVERMTKNITTPSIFSRKYGLLSVEEAEQDAKRIEDLAFATANKHFQNEPDGDGTSAVHVYAKESSKLMLDVIKRGPQEESEVEVSKDGDVFFDISGGSRAFIEEEEARDLLRPLADPRNSYTKIRFSNRSFGSEAAKFAASVLSSIKDQLTEVDLSDFVAGRPEAEALEVMNMFSSALEGSKLRYLNLSDNALGEKGIRAFASLINSQHDLEELYLMNDGISEDAARAVRELLPSTDKIRVLQFHNNMTGDEGATAIAEIVRECPSLEDFRCSSTRIGSEGGVALAEALEHCSHLKKLDLRDNMFGVEGGIALAKTLSVLTHLTEIYMSYLNLEDEGTEALSEALLKSAPSLEVLELAGNDITVKSTGNLAACIASKQSLAKLNLSENELKDEGTILIAKAVEGHDQLVEVDLSTNMIRRAGARALAQTVVKKNTFKLLNINGNFISEEGIDEVNDMFKDCLDKLVPLDDNDPEGEDFEDEDEEEEGEDGNELESKLGSLKIKQGEE