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RWDD3

Gene
RWDD3
Protein
RWD domain-containing protein 3
Organism
Bos taurus
Length
267 amino acids
Function
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination (By similarity).
Mass
30.406 kDa
Sequence
MAEPVRQELSALAAIFCGPDEWEVLSLSETDGAVFRILTKAEGFMDTDIPLQLVFHLPLSYPYCLPGIVVNSKHLTRAQCEIVKEKLLEQAETLLLEPMVHELVLWIQENLRHILKCPEAGGGSEKCSSAASMTVDDGLWMTLLHLDHMRAKAKYVKTVEKWASDLRLTGRLMFMGKIILILLQGDRNDIKEYLILQKTCKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSSLDELQKEFETTGLKKLFSECVLRLVK

Gene
RWDD3
Protein
RWD domain-containing protein 3
Organism
Homo sapiens
Length
267 amino acids
Function
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.
Mass
30.543 kDa
Sequence
MAEPVQEELSVLAAIFCRPHEWEVLSRSETDGTVFRIHTKAEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQLTRAQCVTVKENLLEQAESLLSEPMVHELVLWIQQNLRHILSQPETGSGSEKCTFSTSTTMDDGLWITLLHLDHMRAKTKYVKIVEKWASDLRLTGRLMFMGKIILILLQGDRNNLKEYLILQKTSKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSALDELQKEFETAGLKKLFSEFVLALVK

Gene
Rwdd3
Protein
RWD domain-containing protein 3
Organism
Mus musculus
Length
267 amino acids
Function
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination.
Mass
29.89 kDa
Sequence
MAEEVRQELSALAAIFCGPNEWEMLSCSETDGAVFRIHTTAEGLVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEKLLGEARKLVSEPMVHELVLWIQQNLRLVLSQPETVSSHEKCTLPESATGDDGPWMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVLSETKVQTEHKRFLAFEVKEYSTLEELQKEFGAAGLGELFSECVLGLVK

Gene
RWDD3
Protein
RWD domain-containing protein 3
Organism
Pongo abelii
Length
267 amino acids
Function
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination (By similarity).
Mass
30.435 kDa
Sequence
MAEPVQEELSALAAIFCGPHEWEVLSRSETDGTVFRIHTKAEGFMDADIPLESVFHLPVNYPSCLPGISINSEQLTRAQCVTVKEKLLEQAESLLSEPMVHELVLWIQQNLRHILNQPETGSGYEKCTFSTSTTVDDGLWITLLHLDHMRAKTKYVKTVEKWASDLRLTGRLMFMGKIILILLQGDRNNLKEYLILQKTSKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSALDELQKEFETAGLKKLFSEFVLALVK

Gene
Rwdd3
Protein
RWD domain-containing protein 3
Organism
Rattus norvegicus
Length
267 amino acids
Function
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination.
Mass
30.138 kDa
Sequence
MAEEMRQELSALAAIFCGPHEWEMLSCSETDGAVFRIHTTAEGLAGEDVPLELAFHLPAGYPSCLPGISVNSERLTRAQCVTVKEKLLGEARRLLSEPMVHELVLWTQQNLRHILSQTETESSNGTCTLPESSTVDGGLWMTLLRLDHMRARTKYVKVVEKWASELRLTGRLMFMGKMILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVLSETKVQTEHKRFLAFEVKEYSTLEELQKEFETAGLQELFSECVLGLVK

Gene
rwdd3
Protein
RWD domain-containing protein 3
Organism
Xenopus tropicalis
Length
265 amino acids
Function
Enhancer of SUMO conjugation. Increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and ube2i/ubc9 and transfer of SUMO to specific target proteins which include hif1a, pias, nfkbia, nr3c1 and top1. Has no effect on ubiquitination (By similarity).
Mass
30.038 kDa
Sequence
MSESALEEVAALSAIYCRDGECEVLSSSVNGITVMIQTGVQGITGSEIHLKLIFDLPVEYPSSLPNISVSSEELTRAQRKDLRDKLVEQAKQHILEPMIHDLVVWTQQNLNNLIVQPEPSILEGHFPLSLDTITEETTWTILLRLDHMRAKSKYVKTVEKWTNDLKLCGRLMFLGKLILILLQGDRKSTRDYLVLQKTCKVDVDSSGKKCKEKMISVLCETILPLKQKRFTTFEVKEYSSVSDLQKEFEAAGLQTIFSEFVQALF

Gene
rwdd3
Protein
RWD domain-containing protein 3
Organism
Danio rerio
Length
257 amino acids
Function
Enhancer of SUMO conjugation. Increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and ube2i/ubc9 and transfer of SUMO to specific target proteins which include hif1a, pias, nfkbia, nr3c1 and top1. Has no effect on ubiquitination (By similarity).
Mass
29.655 kDa
Sequence
MSKEAFDELSVLSAIYCEQGEFEVLEESPEKGVVFRVHTLIDNNEKTPLDIIFHISPEYPNTPPDISISSNHLSRRQCHDLRRSLLDTAQSLPAEPMVHGLMLWLQENFSDLIKTSSCHSAEVRPETTEETWTALLHLDHMRSKAKYIKLIEKWTLELRLTGRLFTGKLILILLQGTKENIKQYIHLLKSVKVDVDSSGKRCKEKMMSVLCEIPKPEDKIMMTTFEVKDILSLDDLRREFDLIGLNELYHQFVSSLT