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RUMGNA_00694

Gene
RUMGNA_00694
Protein
3-beta-hydroxycholanate 3-dehydrogenase (NADP(+))
Organism
Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9)
Length
276 amino acids
Function
Involved in the modification of secondary bile acids to form iso-bile acids via epimerization of the 3-OH group through 3-oxo-intermediate. In vitro, catalyzes the reversible oxidation of 12-alpha-hydroxy-3-oxo-5-beta-cholan-24-oate (3-oxo-DCA) and 3-oxo-5-beta-cholan-24-oate (3-oxo-LCA) to yield isodeoxycholate (isoDCA) and isolithocholate (isoLCA), respectively. It prefers NADPH to NADH.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
29.047 kDa
Sequence
MNFGGFIMGRFDEKIMLVTGATSGIGRAVAIRAAKEGATVVAVGRNEERGAAVVAAMEEAGGKGEFMKCDVSNKDAVKALFAEIQEKYGKLDVAVNNAGIVGASKTVEELEDDDWFQVIDANLNSCFFCCREEVKLMQPSGGAIVNVSSVAGMRGFPSAAAYVASKHAVSGLTKAVAVDYATKGITCNAICPAGTDTPLTERSSADIKTRMAEIAAQGKDPMEWLKNSMLSGKTETLQKKNATPEEQAATILYFASDEARHITGSIVASDGGFTTY