RUBCNL

Protein associated with UVRAG as autophagy enhancer

663 amino acids

Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (By similarity).

73.604 kDa

MVSQSSGRQDSPVDPWEGVSDDPGNTDGLPSLLDTEHPFCPSDIRFTRHRAAWINPPCAQQQLQDASPQVLAVGNRESHTASNTKSPLGTSPLSLGDSVVETSLPKGTTDSLGSSSAWGTAGNGSDSSVTLKEERAGLPRRCPHTSLITSSKTVSGPPCPEDGRAFFKPSQLTASADADAVQVGGRTVSSNSFSPEAFVLPVDAEKENAHFYVADMIISVMEKMKCNILSQQHTETWSTEEAGRSLGNSRADLEGTFYTHVKQESGSSTSSDSGYEGCVLQVSPVVETPTFSEVTEEDCKCDFDDFVIVELGDFSNTTEPCGCSSDTSKSVIHEPNFNSAELIAKELYRVFRKCWMLAEVHYQLTGSLDAAGSIVINEERVQKDFESSTDVVQEIKLKSRIRGTGDWAPPRFQIIFDIHPPLKRDLVVIAQNFFCAGCGTPIEPKFVKRLRYCEYLGKYFCDCCHSYSESCIPARILRMWDFRKYYVSNFSKRLLDHIWHEPIFNLLHVSHGLYTKAKELDRVREIQEQLFHIKKLLKTCRFAESTLKEFEQLPGHLTEALHLFSLEDMVKVKKGLLAPLLKDILKASLEHVASCELCQGKGFICEFCRSTAVIFPFQTATCRRCSACRACFHKQCFQSSKCPRCARITARRRLLESLPSAAT

RUBCNL

Protein associated with UVRAG as autophagy enhancer

662 amino acids

Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable).

73.457 kDa

MVSQSTVRQDSPVEPWEGISDHSGIIDGSPRLLNTDHPPCQLDIRLMRHKAVWINPQDVQQQPQDLQSQVPAAGNSGTHFVTDAASPSGPSPSCLGDSLAETTLSEDTTDSVGSASPHGSSEKSSSFSLSSTEVHMVRPGYSHRVSLPTSPGILATSPYPETDSAFFEPSHLTSAADEGAVQVSRRTISSNSFSPEVFVLPVDVEKENAHFYVADMIISAMEKMKCNILSQQQTESWSKEVSGLLGSDQPDSEMTFDTNIKQESGSSTSSYSGYEGCAVLQVSPVTETRTYHDVKEICKCDVDEFVILELGDFNDITETCSCSCSSSKSVTYEPDFNSAELLAKELYRVFQKCWILSVVNSQLAGSLSAAGSIVVNEECVRKDFESSMNVVQEIKFKSRIRGTEDWAPPRFQIIFNIHPPLKRDLVVAAQNFFCAGCGTPVEPKFVKRLRYCEYLGKYFCDCCHSYAESCIPARILMMWDFKKYYVSNFSKQLLDSIWHQPIFNLLSIGQSLYAKAKELDRVKEIQEQLFHIKKLLKTCRFANSALKEFEQVPGHLTDELHLFSLEDLVRIKKGLLAPLLKDILKASLAHVAGCELCQGKGFICEFCQNTTVIFPFQTATCRRCSACRACFHKQCFQSSECPRCARITARRKLLESVASAAT

Rubcnl

Protein associated with UVRAG as autophagy enhancer

648 amino acids

Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (By similarity). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (By similarity). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (PubMed:30704899). May act as a tumor suppressor (By similarity).

72.279 kDa

MVSQSIGWGDSPVDLCEGSNRAFQDTDQPACQLDVRLLRHKASWINPLCVQQPLQELCPQRPTVQSSENHVVLDTPSPLRLSILSYRDSLAEMPLSENTADVICSNSAHCSGGKEGDFFLATEEQEVHLQQESLLKNPKTVATSPSPKEGSARSESPHLTASTDDGDARSSSRSHAWNFFPLETFMLPADVEKENLHFYAADIIISVIENMKCNLPNQQQPERWDTEDASRLRGTGAEMTFYTHIKQEPGSSASSHTGCEGCAALQVSPVAETLSYCPVAGEACKHDLNKLVMLELGKYNDITKGCRCSYNSSKSATCESNLSPAGCLARELFRGFCKCWMLSEVNCQLPGSPTTASSGVGDEEYAEEDFDSSVDAAREVMLKSRVPGTEDWVLPRCQIILTVHPPIKRDIAVVAQNFFCAGCGTPIQPKFVKRLRYCEYLGKYFCASCHSSAESCIPARILTMWDFRKYQVSDFSKWLLDSVWHQPVFKLLGGHHSLYAKAKELDRVKDLQEQLFHIKKLLKTCRFADSVLKEFEQVPSHLTDECHIFSMDDFLRTKKGLLAPLLKDILRASLAHVDSCELCQGKGFICEFCQSTTVIFPFQTTTCRRCAACRACFHKQCFQSSRCPRCARIIARRQHLESLPTAAT