Protein
E3 ubiquitin-protein ligase RNF123
Organism
Rattus norvegicus
Function
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.
Sequence
MTSKGAAMSFSRKSYRLTSDAEKSRVTGIVQEKLLSDYLYRIFSSPDHGTPAATSRKPLNFHNLPEHVDQLLQVDDEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSSTCVYKGKWVYEVLISSQGLMQIGWCTINCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGFRPLQDPPFADLVRAQRLLGCFQTVLSVELDPVEGRLVEKESSEWQLHGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGIVEKGTPEQAQSVVHQILDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTMAVLRHEKSRKFLLSNVLFDMLRSVVFFYIKSPLRVEEAGLKELIPTTWWPHRSSREGRDGQEAKEETTEERQRRRAYERGCQRLKKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNTPVLCPPEYMVCFLHRLVSALRFYWDEYKASNPRASFSDEAYIPPQIFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQAATMDDLDEDEEPAPTAAQSWRARQRPVQALAIGGALPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRLLSTMEKVKVRSLNVEQRTREDIEGSHWNEGLLLGRPPEEPERPLTENSLLEVLDGTVMMYSLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLQTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADPRIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKPEDANLPSLQKPCPSTLLQQHMADLLRQGSDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWSRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVRLLAHGPSSETEQATSVLLADPCFQLRSIRYLLGQPEPLAPGSALPAPDRKRFSLQSYADYISAEELAQVERMLAHLTAASAQAAAASLPTNEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKATIVSVEDWDKAASTSATSSAA