About Products Protein Database Contact

RIPt

Gene
RIPt
Protein
Ribosome-inactivating protein PMRIPt
Organism
Polygonatum multiflorum
Length
603 amino acids
Function
GalNAc-specific agglutinin. Behaves as a type-2 ribosome-inactivating protein. Inhibits mammalian ribosomes (PubMed:10785398). The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA (Probable). The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity) (Probable). Involved in plant defense against insects (By similarity). Has very low cytotoxic activity against the human tumor cell lines CEM and Molt4 (PubMed:10785398).
Similarity
Belongs to the ribosome-inactivating protein family. Type 2 RIP subfamily.
Mass
66.734 kDa
Sequence
MRVVAGILYIVVMAICGLGIQGGTLQDYPSVYFQDSTLQQDFPTIFFNILAGETYGDFIADLREIVTRTADTKNGSIPVLLNPAHPVPVRERFVKVHLTGRNGKTVILALDVTNLYVAAFSANNVAYFFRDFSALERENLFSGMLTIRLSFTSNYVSLEHKAGVGRENISLGPTPLDEACTKSLWSGTTVTEASIAKALLVVIQMVSEAARFRHIEERVRRSFTAADHDQLTFRPDGLMLSMENEWPSMSLEVQRSIEGGIFIGVVQLQDESFQPLRVDNFNTLSRYTMVALLLFRCGHPRATAGTSSTTPAAAQIIRMPVDVLAGEEYYDEETCTVGEPTRRISGLDGLCMDVRNESNNDGIPIQLWPCGAQRNQQWTFHTDGTIQSMGKCMTSNGYHPGDYVMIFNCSTAPVPDATKWVVSIDGSITNPHSGLVLTAPQAAQTTILLVVRNTHSAKQGRSVGDDVEPIVTYIVGFKYMCLQGNNENNTRVWLEDCAVDRPQQWWALYSDGTIRVDSDRSLCVTSDGHSSRDAIIILTCDGGINQRLVFNTDGTILNPNAQLVMDVRQSNVALRQIILYQPTGNPNQQWMTMITRTRPSLTS