ric8a

Synembryn

573 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G-protein coupled receptors. In addition to its GEF activity, it plays an essential role in cortical subcellular localization of heterotrimeric G proteins, suggesting it acts as a facilitator of G-alpha function through control of its membrane targeting and/or assembling of associated components rather than a GEF. Also required during gastrulation and sensory organ precursors (SOP) formation.

Belongs to the synembryn family.

65.602 kDa

METEHLKRLEAKEADHIPAILDEFNTKNADLLVFDSFRTDNLWHELWLAIFGILDDQRLSHLHTQCLNTVRILTRDEFSLQTNYIEQEVNTLLKLARIEAGSLKLPATPDELKQEEREEPQLEPSQAQSEVIAEALKCLCNLVYQSSDCRRQCLRQHCLDAILKRVASSMRHPCALEYYDMKLLFLLTALEPAARSRLQIDLNGLTYMTKWLDDKLGEDSVGEEQLNIICELLKVMFNVTSAPDKSPNEYEIQSLHLTGVLRELLLRFGDLATEKDRAVVTHAINLLTNISGSCLTELTLRCSNAELESHKEREQDNEKEKDTEAGAGAKPRECCSQCFEKRNVRSLDVLLRYLRQSLAQQEAEASSHELLSPVLTVLVKCARSDRVMRHYLRQEILPPLRDVSQRPEVGQELRNHLCRFLTLPAMILRDLSAELLFVLCKENVGRMIKYTGYGNAAGLFAKRGILDCRRVEGTDYSSDSEDSDTEEYKQQQQGINPVLGCVEPRSKSHLDDISEEQKEYEAMQLVNLIEQLRQGGIVKPAMIDKDGRPQPLEHILQLQEELPQQQLDQKRKT

ric8a

Synembryn

566 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G-protein coupled receptors. In addition to its GEF activity, it plays an essential role in cortical subcellular localization of heterotrimeric G proteins, suggesting it acts as a facilitator of G-alpha function through control of its membrane targeting and/or assembling of associated components rather than a GEF (By similarity).

Belongs to the synembryn family.

64.45 kDa

MDAEHLKRLEGREAEHIPDILNEFNKKHADLLVFDSFHSDNQWHELWLAIFGILDDAQLGHLHTQCLNTVRILTRDEFSLQTNYIEHEVSQLLRLARVEASSLKLPATPDELKQQEEGQLQLQEQPSLAQSDIIAEALKCLCNLVYQSADCRRQCLRQHCLDAILKRVASSMRHPCALEYYDMKLLFLLTALEPAARTRLQIDLNGLTYMTKWLDDKLAEPSCSEEQLNIICELLKVMFNVTSAPDKSPNEYEIQSLHLTGVLRELLLRFGKMATDKERSVVTHAINLLTNISSSCLIELTLKCSNAEEQPKKAVEGVAKAKPAKCCALCFEKRNVRCLTVLLNYLRQALAQQEAEASSHELLSPVLTVLVKCSRSDRVMRHYLRQEILPPLRDVSQRPEIGQELRNHLCRFLTLPAMILRDLAAELLFVLCKEDVGRMIKYTGYGNAAGLFAKRGILDCRRVEGADYSSDSEDSDTEEYKKHQQGINPVLGCVEPKSKHNPLDDMTEEQKESEALQLVNLIEQLRQGGIVKPALIDKDGKPQPLEHILQLQEELPQQQLEQKRKT

ric8a

Synembryn-A

548 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).

Belongs to the synembryn family.

61.996 kDa

MDLNAIIEKMETGDQDAALTALQTYNKEKSQCFSFTSGEEEDRERLGELVLSFLERDLQPSCQLACLETIRILSRDKKSLSPFATRHAMQILIRHAGLGQGEGVTPEIPDLEVIVEALKCLCNIVFNSEAAQEAAADLQLMVGLAERLKQCREPQWNHDVRFFDLRLTFLITALRVDVRAQLAHELRGVSLLSEALDATFGLCWPDMYEVARAGFDGCSELPPLGRQETERVMEILKILFNVTFDSNRRHVDEEEAATYRHLGAILRHCIMSSAEGEERTEEMHSHTVNLLGNLPLPCLDVLLMPKVQQGSIEYMGVNMDAVKVLVEFMEKRLDRGNKLKETLLPSLNLLTESARIHRETRKFLRNKVLPPLRDVKNRPEVGNALRNKLVRLMTHIDTDVKHCAAEFLFVLCKESVSRFIKYTGYGNAAGLLAARGLMRGGRDPGHYSEDEDSDTEEYREAKPHINPVTGRVEEEQPNPMEGMTDEQKEYEAMKLVNMFDKLSREQVIQPMKIGADGKMTSMEPHELHHLASQQFGESNNSDSDSDTN

RIC8A

Synembryn-A

539 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).

Belongs to the synembryn family.

61.504 kDa

MELRTVVATVESGEQDAVLKVLQIYNQEKSQCFTFDDEEREERKKMAQLLIKFLERELQPSCQVTCLESIRILSRDKYCLEPFTTEEGLKTLSRHAGIDYSEELIREVPDLEVILESLKCLCNIVFSSPRAQELTAEARLVVGLTKRIKLYNERSLPHEVKFFDLRLLFLLTALRVDIRQQLAQELRGISLMTDTLELTLGVKWMDPYEVATEEGLLPPLPRQETERAMEILKVLFNITFDSSKREVDEEDAALYRHLGALLRHCLMISADGEDRTEEFHSHTVNLLGNLPLKCLDVLLTPKVRPGSLEYMGVNMDAVNILLDFLERRLDRGHKLKESLTPVLNLLTESARVHRQTRKFLKAKVLPPLRDVKNRPEVGNSLRNKLVRLMTHIDTDVKHCAAEFLFVLCKESVSRFVKYTGYGNAAGLLAARGLMAGGREEGEYSEDEDTDTEEYKEAKPNINPVTGRVEEKLPNPMEGMTEEQKEYEAMKLVNMFDKLSREQVIQPMGITPSGNLAPMENAIRDMADERSSSDSDLGLD

ric8a

Synembryn-A

539 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).

Belongs to the synembryn family.

61.274 kDa

MDLGALLDELESGDQELVQKSLAEYNQENSQCFFFNAEQREERKKLGELVISFLNRDLQPSCQIACLETIRILSRDKYALSPFTGRSAIQTLAQYAGLDYSEEMEMPCIPDGESAVEALKGLCNIIYNSVEAQEVAKDLRLVCGLARRLKLYNETRSSHESKFFDLRLLFLLTALSVDMRRQLAQELRGVSLLTDALESTLALKWSDIYEVVTDHLAPPLGKEETERVMEILKALFNITFDISRREVDEEEAALYRHLAAILRHCLLRQSDGEDRTEEFHGHTVNLLVNLPLMCLDVLLTPKVEQGSVEYMGMNMDTVEVLLQFLHRRLDRGHKLREMLTPVLNLLTESSRVHRETRKFLRAKVLPPLRDVKNRPEVGNTLRNKLVRLMTHVDTDVKHCAAEFLFVLCKENVSRFVKYTGYGNAAGLLAARGLLAGGRGEGCYSEDDDTDTEEYREAKANINPVTGRVEEKQPNPMDGMTEEQKEYEAMKLVNMFDKLSREQIIQPMGVTSDGRLGPLDEAAQKMLQRQESSDLDSDSD

ric8a

Synembryn-A

539 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).

Belongs to the synembryn family.

61.452 kDa

MDPGTLLDKLESGDQELVQKALAEYNQENSQCFFFNAEQREERKKLGELVIKFLNRDLQPSCQMACLETIRILSRDKHALSPFTGRSAIQTLAQYAGLDYSEEMEMPSIPDGESAVEALKGLCNIIYNSVEAQEVAKELRLVCGLARRLKLYNETRSSHESKFFDLRLLFLLTALSVDMRKQLAQELRGVSLLTDALESTLALKWSDIYEVVTDRLAPPLGKEETERVMEILKTLFNITFDISRREVDEEDAALYRHLAAILRHCLLRQCDGEDRTEEFHGHTVNLLVNLPLMCLDVLLTPKVEQGSVEYMGMNMDTVEVLIQFLDRRLDRGHKLRETLTPVLNLLTESSRVHRETRKFLRAKVLPPLRDVKNRPEVGNTLRNKLVRLMTHVDTDVKHCAAEFLFVLCKENVSRFVKYTGYGNAAGLLAARGLLAGGRGEGRYSEDEDTDTEEYREAKPNINPVTGRVEEKQPNPMDGMTEEQKEYEAMKLVNMFDKLSREQIIQPMGVTSDGRLEPLDEAAQKMLQRQESSDLESDSD

RIC8A

Synembryn-A

531 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Belongs to the synembryn family.

59.71 kDa

MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

RIC8A

Synembryn-A

530 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).

Belongs to the synembryn family.

59.499 kDa

MEPRAVADALETGEEDVVMEALRAYNRENSQSFTFDDAQQEDRKRLAKLLVSVLEQGLPPSRRVIWLQSIRILSRDRSCLDSFTSRRSLQALACYAGISASQGSVPEPLNMDVVLESLKCLCNLVLSSPVAQALAAEAGLVVRLAERVGLCRQSSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELQGVRLLTRALELTLGMTEGERHPELLPPQETERAMEILKVLFNITFDSIKREVDEEDAALYRHLGTLLRHCVMLAAAGDRTEELHGHAVNLLGNLPVKCLDVLLTLEPHEGSLEFLGVNMDVIRVLLSFMEKRLHQTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGELLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGQLTSLQDAMCETMEGQLSSDPDSDPD

RIC8A

Synembryn-A

530 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).

Belongs to the synembryn family.

59.661 kDa

MEPRAVAEAVETGKEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVTWLQSVRILSRDRNCLDPFTSRQSLQALACYADISGSEGSVPDSPDMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVHLLTDTLELTLAVTPEGNPPKLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHEDSVEFMGVNMDVIRALLIFLEKRLHQTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Ric8a

Synembryn-A

530 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).

Belongs to the synembryn family.

59.847 kDa

MEPRAVADALETGEEDAVTEALRSFNREHSQSFTFDDAQQEDRKRLAKLLVSVLEQGLSPKHRVTWLQTIRILSRDRSCLDSFASRQSLHALACYADITVSEEPIPQSPDMDVLLESLKCLCNLVLSSPTAQMLAAEARLVVRLAERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLLTDALELTLGVAPKENPPVMLPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRHCVMVEAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVISALLAFLEKRLHQTHRLKECVAPVLNVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTEEYREAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD

RIC8A

Synembryn-A

530 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).

Belongs to the synembryn family.

59.695 kDa

MEPRTVAEAVETGKEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVTWLQSVRILSRDHNCLDPFTSRQSLQALACYADISVSEGSVPESPDMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPKLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLFTLEPHGDSVEFMGVNMDVIRALLIFLEKRLHQTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Ric8a

Synembryn-A

529 amino acids

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Belongs to the synembryn family.

59.833 kDa

MEPRAVADALETGEEDAVTEALRSFNREHSQSFTFDDAQQEDRKRLAKLLVSVLEQGLSPKHRVTWLQTIRILSRDRSCLDSFASRQSLHALACYADIAISEEPIPQPPDMDVLLESLKCLCNLVLSSPTAQMLAAEARLVVRLAERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLLTDALELTLGVAPKENPLVILPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRHCVMADRAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVINALLAFLEKRLHQTHRLKECVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSRMRTPTEEYREAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRLIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD