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RIB7

Gene
RIB7
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
252 amino acids
Function
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Similarity
Belongs to the HTP reductase family.
Mass
28.316 kDa
Sequence
MPIQPLKKELVSFLEPYMPENAGVLGEQEKPYVILTYAQSLDARIAKIKGTRTIISHQETNTMTHYLRYKFDGIMLGCGTVLVDDPGLNCKWWPDDEPKPEHFAEHSPRPIILDPNGKWKFEGSKMKTLFDSGDGKAPIVVVKKLPEVVEENVDYLVMQTNFTGKVDWHDLFIQLKSQFGLKSIMVEGGGIVINDLLQRPHLIDALVITVGATFLGSEGVEVSPLIEINLKDISWWKGTRDSVLCSRLVSHS
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase: RIB7

Gene
RIB7
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Organism
Kluyveromyces marxianus
Length
249 amino acids
Function
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Similarity
Belongs to the HTP reductase family.
Mass
28.142 kDa
Sequence
MVLLPLKKDLVPFLEPYLPDEERDADKEKPYVILTYAQSLDSRIAKIKGTRTFISHEETKTMTHYLRYKFDAIMLGCGTVMIDDPGLNCKWWPEDEKPEHLAGISPRPIILDPNCKWKFADSKMKKLYEAGDGKAPIIVVKELPSEPEEGVDYLVMRTNFTGKMDWSDMLVQLKSKFNVKSVMVEGGGIVINDLLQRPNLVDALIITLGATFLGSEGVEVSPLVEIKLKDVSWWTGDLDTVLCSRLVTH
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase: RIB7

Gene
RIB7
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
247 amino acids
Function
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Similarity
Belongs to the HTP reductase family.
Mass
27.372 kDa
Sequence
MSLLPLTPSLRPFLEEYLPRPCSNRPFVTLTYAQSLDSRIAAKPGEQTKISHLETKTMTHYIRSKHDGIMVGIGTVLADDPKLNCRFEAEDGNISTPRPIILDPTGKWAYHKSQLRSVCDNNKGLAPFILIDETVTPRNEDVEVLDKQDGAFVRLPLLRNADKVGNWNIILKKLFQLGIKSIMVEGGASIINDLLVYSKIIDSLIITIGPVFLGKDGVEVSPSGHAGLIDVKWWQGIQDSVLCARLT
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase: RIB7

Gene
RIB7
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
246 amino acids
Function
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Similarity
Belongs to the HTP reductase family.
Mass
26.93 kDa
Sequence
MALIPLSQDLADILAPYLPTPPDSSARLPFVTLTYAQSLDARIAKQKGERTVISHEETKTMTHYLRYHHSGILIGSGTALADDPGLNCRWTPAADGADCTEQSSPRPIILDVRGRWRYRGSKIEYLHNLGKGKAPIVVTGGEPEVRELGVSYLQLGVDEGGRLNWGELFERLYSEHHLESVMVEGGAEVLNQLLLRPDIVDSLVITIGSKFLGSLGVAVSPAEEVNLEHVNWWHGTSDSVLCGRLA
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase: RIB7

Gene
RIB7
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
244 amino acids
Function
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Similarity
Belongs to the HTP reductase family.
Mass
27.116 kDa
Sequence
MSLTPLCEDLPQFLQNYLPNAGQTENTIVPFVTLTYAQSLDARVSRGPGVRTTISHPETKTMTHYLRHHHDGILVGSGTVLADNPGLNCKWGPDPAANSPRPIIIDTKQKWRFDGSKMQELFIKRQGKPPIVVVTSEPIIKEQHVDYAICPINDTTKLVDWKKLFEILKEEFNIRSVMVEGGANVINQLLLRSDIVNSLIITIGSTFLGSSGTEVSPPQTVNLKDMSWWKGITDVVLCARLADD
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase: RIB7

Gene
RIB7
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
244 amino acids
Function
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Similarity
Belongs to the HTP reductase family.
Mass
27.568 kDa
Sequence
MLRVRDDLPPFLKNYLPDGHRNGRPFVTLTYAQSIDAKIAKQRGVRTTISHIETKEMTHYLRYFHDGILIGSGTVLADDPGLNCKWIGPNNDPDESMEEKSPRPIILDPKLKWKYSGSKMEELCNQGMGKPPIVITTKTPKVKEANVEYMIMEPDANDRISWKSILDTLRRNYDMKSVMIEGGSHVINQLLMCSDLIDSLIVTIGSIYLGSEGVTVSPPDEVKLKDISWWKGTSDVVMCSRLQN
Protein
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase: RIB7