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RHNO1

Gene
RHNO1
Protein
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
Organism
Bos taurus
Length
241 amino acids
Function
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity).
Mass
27.324 kDa
Sequence
MPPRKKRRQAAQKPQLLFHQQPLEAPKHRCRFPQLPVVTHTRQVPSKPVDHNTITSWVSPQFDTTAESWFPGKRKHHHRDHARRSSRKSTSSRFPCLTFETPQSSASSATPGILASRDGPSQPEKDISGRPLVPMLSPQSCRELSAHTFPDFPCVFIPPDIQTPESPGQGEPIPSELRENSLPSCSLHTSTPKSPEPGPVLVTDTPEEKYGIKVTWRRRRHLFAYLRERGKLSRSQFLVKD

Gene
RHNO1
Protein
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
Organism
Homo sapiens
Length
238 amino acids
Function
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.
Mass
26.709 kDa
Sequence
MPPRKKRRQPSQKAPLLFHQQPLEGPKHSCASTQLPITHTRQVPSKPIDHSTITSWVSPDFDTAAGSLFPAYQKHQNRARHSSRKPTTSKFPHLTFESPQSSSSETLGIPLIRECPSESEKDVSRRPLVPVLSPQSCGNMSVQALQSLPYVFIPPDIQTPESSSVKEELIPQDQKENSLLSCTLHTGTPNSPEPGPVLVKDTPEDKYGIKVTWRRRQHLLAYLRERGKLSRSQFLVKS

Gene
Rhno1
Protein
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
Organism
Mus musculus
Length
235 amino acids
Function
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity).
Mass
26.82 kDa
Sequence
MPPKKRRRQSQKAQLLFHQQPLEGPKHHYESCQQPITHTVQVPSKPIDQSTVTSWVSPQFDRAAESRFLIHWKPHRDQARRPTRRSTCKFPRLTFESPQSSSSETLLLSNRVQPQNSEKDPPRRPLVPLFSPQSCGELSVHVPHSLPHVFAPPDIQTPDSSVRDDPISPDQKENSFPSCILGPGTPSSPEPGPVLVKDTPEEKYGIKVTWRRRRHLFAYLKEKGKLDGSQFLVKI

Gene
Rhno1
Protein
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
Organism
Rattus norvegicus
Length
235 amino acids
Function
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity).
Mass
27.07 kDa
Sequence
MPPRKRRRQCQKAQLLFHQQPLEGPKPHYESHQQPITHTVQVPSKPIDQSTITSWVLPQFDTAAESRFPTHRKHHRDQARHPTRRSTCKFPRLTFESPESSSSETLLLSNREQLQNSEKDAPRRPLVPLFSPQSCGELSVHVPQSLPHVFMPPDIQTPGSSVREDPISPDQKENSLPSCILGPRTPRTPEPGPVLVKDTPEEKYGIKVTWRRRRHLFAYLKERGKLDKSQFLVKT