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RFX2

Gene
RFX2
Protein
RFX-like DNA-binding protein RFX2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
1111 amino acids
Function
Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1.
Similarity
Belongs to the RFX family.
Mass
125.295 kDa
Sequence
MSNNPHRTHKRQKSSVSNPGYYFTPETKSEIQQQQPQQQESQQQQQQQQQQHSQTHNIYDNDNYMNYNFPPTSNRPRASTTTGTTSTTHPGSELSHESHSVHTSPLKRTASSELDQPIPAMAPSSPLVSSAPYYYQQPSQQQNLSYHDHHHQQQQQQSTPQGQQLSQQTQSNSQSGVPPPLYGTSSSIPPGSTMQPSTSFAFHTSHSTYNPSFDSSNLYNSAFRLPEYPTTSSSSLLSTTGGKQFQQSSALLPSGTLPPSILGTSSSSHVSALRQHQKNNLSISSHLTLFSLSGNNSSQLQSQGSSFQQSETGVDDTKRSSKESTTIFNDLLFHLTSVDGSNINTFLLSILRKINSPFTLDDFYNLLYNDRQRTLLDNSNYQNRIDKTIVSPSDTDMTVSIINQLLNFFKTPSMLVDYFPNMEDKDNKLANINYHELLRTFLAIKILHDILIQLPISEDDDPQNYTIPRLSIYKTYYIICQKLIASYPSASNTRNEQQKLILGQSKLGKLIKLVYPNLLIKRLGSRGESKYNYLGVMWNANIVQEEIKQLCDEHELNDLNEIFNSDNNNPFASIAPSGSATTGSTPRRGLSHKRTSSKQKIKTEPVAGNPFLQPLQTSHHHHHSHHHHHEEQSQEESLSQQMGEHITAPRLSFLRANSKYPTDVNLSVLDDDNWFVRLSYECYARQPALNRDLIQQIFLKNEFLLNNSSLLQNLMDSIIKPLVMQETYSNVDLVLYLAILLEILPYLLLVKSSTNINLLKNLRLNLLHLINNFNNELKKLDSPKFPIERSTIFLVLVKKLINLNDLLITFIKLINRDNCKTTMSSDIENFLKINSQTVKLDDDDNSFFFNLNTTSMGEVNFNFKNEILSNDLIYTLIGYNFDPTTNSELKSSISMNFINEEINVIDEFFKNDLLNFLSTDFHAGLDDDNGEEDDDEEAGPGSTHPMGATGSQGSLSPEPVSTGNPSVPPTRNTSISEVNAENKRGNEAVLTPKETAKLNSLISLIDKRLLSSQFKSKYPILMYNNCISYILNDILKHIFLKQQQQQLQSSSSQLHDTQPLTQQDTAQGIGSSSSNANNTNSSFGNWWVFNSFIQEYMSLIGELVGLHDNLV

Gene
rfx2
Protein
DNA-binding protein RFX2
Organism
Danio rerio
Length
734 amino acids
Function
Transcription factor that acts as a key regulator of ciliogenesis (PubMed:22233545). Specifically regulates expression of genes required for cilium assembly and function (PubMed:22233545). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (By similarity).
Similarity
Belongs to the RFX family.
Mass
81.854 kDa
Sequence
MQRSEGGSETPSTVALRTSTSAQAPVVQPVPASQQRVLVQATGSSQKGAQVQQLPVPRVQQVPQQVQQVQHYHSQQVQYVEGAEAVYPNGTIRAAYSYNPESQLYGQGSGSAYFDSQAGGAQVTTVVSSGGVPTHGMVGIAMDVGGSQIISSGSAYLIHGGMEGGRHHTSHSSRSSSAMLEMAIENLQKSEGIATHKSSLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRMQEDTQYMAMRQTPVHQKQRFKPFHKMDGMGDSLNSGSQHLSSTPEQSVAAQCQHHQQYIDVSHVLPPFPSLDLGSCPLPESISMTDVKKLQSSYRIHCEATLDVVMNLQFHLIEKLWQTFWHSTAPSSDGATTIPNSEEDVEDIRGFPRDKLITLCKYEPIKQWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTSAMTNFPPEIISTKAAVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDESVVQRLELDFKATLQQQSSLDQWAAWLDNVVNQVLKPYDGSLSFPRAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFSDLSSLMPSLKEQDTSFSDDMTSDGDMSRMSERSLTEPAVKRERIEIPHSLQEI

Gene
RFX2
Protein
DNA-binding protein RFX2
Organism
Homo sapiens
Length
723 amino acids
Function
Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene HIST1H1T (By similarity).
Similarity
Belongs to the RFX family.
Mass
79.987 kDa
Sequence
MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQVQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI

Gene
RFX2
Protein
DNA-binding protein RFX2
Organism
Macaca fascicularis
Length
723 amino acids
Function
Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene HIST1H1T.
Similarity
Belongs to the RFX family.
Mass
79.865 kDa
Sequence
MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSAPKGAQMQPVSLPRVQQVPQQVQPAQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSAASYFEAPGGAQVTVAASSPPAVPSHSMVGITMDVGGSPIVSSTGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSSLHSTPEQTMAAQSQHHQQYIDVSHVFPEFPAPDLGSVLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDERRGSEAGPDAHSLGEPLVKRERSDPNHSLQGI

Gene
Rfx2
Protein
DNA-binding protein RFX2
Organism
Mus musculus
Length
717 amino acids
Function
Transcription factor that acts as a key regulator of spermatogenesis (PubMed:26248850, PubMed:26162102, PubMed:26853561). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (PubMed:26162102, PubMed:26853561). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:15229132, PubMed:26162102). Probably activates transcription of the testis-specific histone gene HIST1H1T (PubMed:15229132).
Similarity
Belongs to the RFX family.
Mass
79.19 kDa
Sequence
MQNSEGGADSPASVALRPAAQPMPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYAYNPDPQLYAPSSAASYFETPGGTQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGAYLIHGGMDGTRHSLAHTARSSPATLEMAIETLQKSEGLAPHKGGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHGMPDQAMATQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDSCASLPASDEDPEVTLLPKEKLISLCKCEPILQWMRSCDHILYQTLVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHSGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI

Gene
RFX2
Protein
DNA-binding protein RFX2
Organism
Bos taurus
Length
707 amino acids
Function
Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene HIST1H1T.
Similarity
Belongs to the RFX family.
Mass
77.673 kDa
Sequence
MQNSESGSDSPASVALCSSAAAQAPVAQPVTASPQRVLVQAAGSAPKGAQMQPLSLPRVQQVTQQVQPAQHVYPAQLQYVEGGDAVFTNGALRTAYAYNPEPQMYAPSSAASYFEAPGGAQVTVAGSSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDGTRHTLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPVHQKPRYRPAQKTDSLGESGSHSSLHSTPEQAMAAQSQHHQQYIDVSHVFPEFPAPDLGSVLLQESITLHDVKALQLAYRRHCEATLDVVMNLQFHYIEKLWLSFWNSKSSSDGPTSLPASDEEPEGAVLPKDKLVSLCKCDPVLRWMRTCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEEGVVQRLEQDFKLTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKGGCVWALPPVHSGGGGSP

Gene
RFX2
Protein
DNA-binding protein RFX2
Organism
Pongo abelii
Length
704 amino acids
Function
Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene HIST1H1T.
Similarity
Belongs to the RFX family.
Mass
77.621 kDa
Sequence
MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSAPKGAQMQPISLPRVQQVPQQVQPVQHVYPAQVQYAEGGDAVYTNGAIRTAYTYNPEPQMYAPSSAASYFEAPGGAQVTVAASSPPAVPSHSMVGITMDVGGSPIVSSTGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSSSHSGLHSTPEQTTAAQNQHHQQYIDVSHVFPEFPAPDLGSVLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGERLSQNVTSALWPGSEPGSSPGELCSSAWLATLC

Gene
rfx2
Protein
DNA-binding protein RFX2
Organism
Xenopus laevis
Length
694 amino acids
Function
Transcription factor that acts as a key regulator of ciliogenesis. Specifically regulates expression of genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:22227339, PubMed:24424412). Required for neural tube closure and neural ciliogenesis (PubMed:22227339).
Similarity
Belongs to the RFX family.
Mass
77.784 kDa
Sequence
MQNSDSGSDSATSVALRTSTSAQAPVVQPVPASQQVQTVQHVYPAQVQYVEGDTVYTNGAIRTAYSYNAETQIYAPSSGSSYFDSQGGGAQVTTVVSSPTAIPSHSMVGITMDVSGSQIISSSGAYLIHGGLENSRHTPSHTSRTFPATLEMAIENLQKNEGITSHKSSLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQDHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRIQEDAQYMAIRQQPIHQKQRYRPAQKIDGMGENPANSSQHASPEQSVAAQSQHHQQFIDTSHVFPDFPAPDLGSLLLPEGITMTDIKNLQLMYRRHCEATIDVVMNLQFQYIEKLWQAFWNSKPSSPDGSNPMSSEDEQEPIIPNEKLMVLCKYEPIMRWMRNCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMCDFPQQIVHAKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDEGMVQKLEQDFKLTLQQQSSLDQWANWLDNVVTQVLKPHEGSTSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFSDFASMSPVQMDKDDVSELGSDTEGDPHISGQPPVKRERVELNHSMQEM

Gene
rfx2
Protein
DNA-binding protein RFX2
Organism
Xenopus tropicalis
Length
694 amino acids
Function
Transcription factor that acts as a key regulator of ciliogenesis. Specifically regulates expression of genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Required for neural tube closure and neural ciliogenesis.
Similarity
Belongs to the RFX family.
Mass
77.857 kDa
Sequence
MQNSDSGSDSATSVALRTSASAQAPVVQPVPASQQVQTVQHVYPAQVQYVEGDTVYTNGAIRTAYSYNAEAQIYAPSSGSSYFDSQGGGAQVTTVVSSPTAIPSHSMVGIAMDVSGSQIISSSGAYLIHGGLENSRHTPSHTSRTFPATLEMAIENLQKNEGITSHKSSLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQDHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAIRQQPIHQKQRYRPAQKMDGMGENTANSSQHTSPEQSVAAQSQHHQQFIDTAHVFPDFPEPDLGNVLLPEGITMTDIKNLQLMYRRHCEATIDVVMNLQFQYIEKLWQAFWNSKPSSPDGSNPMNSEDEQEPIIPKDKLMVLCKYEPIMRWMRNCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMCDFPQQIVHAKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEEGMVQKLEQDFKLTLQQQSSLDQWANWLDNVVTQVLKPHEGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFSDFASMSPVLMDKDDVSELGSDNDGDPRISGQPPVKRERVDLNHSMQEM

Gene
Rfx2
Protein
DNA-binding protein RFX2
Organism
Rattus norvegicus
Length
692 amino acids
Function
Transcription factor that acts as a key regulator of spermatogenesis (By similarity). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:14743396, PubMed:15526285, PubMed:16676351, PubMed:18247329). Probably activates transcription of the testis-specific histone gene HIST1H1T (PubMed:14743396, PubMed:15526285, PubMed:16676351, PubMed:18247329).
Similarity
Belongs to the RFX family.
Mass
76.537 kDa
Sequence
MQNSEGGADSPATVALRPAAQPVPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYTYNPDPQLYAPSSAASYFETPGGAQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGTYLIHGGMDSTRHSLAHTARSSPATLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHSTPEQAMAAQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDGRASLPASDEEPEVTLLPKDKLISLCKCEPILQWMRSCDHILYQALVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI