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RFC1

Gene
rfc1
Protein
Probable replication factor C subunit 1
Organism
Dictyostelium discoideum
Length
1401 amino acids
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 1 binds to the primer-template junction (By similarity).
Similarity
Belongs to the activator 1 large subunit family.
Mass
153.582 kDa
Sequence
MAKKANKEQSPKKTSPTSSQGSTATKKKTKTSEPAGTDIRNFFAVIKPSTSGENVKNDLFSKAKEDSNKEFSLSDKENDDVKIISNKKDTTNNDKKKPSENKSPKKKEPSKSIDLTSDEDKSSSEEDKKKPSSSSSKKKPSSSSSSLPNKKKSTLKRLKKKRDDSSSSSSSSESDFDSGSDLDIESIDQKPKTITKKKNLKRKSKPDSSSSSEDETKHQKDKKIKLKTPEKKIEEPEKKVEIPSSTSSISSSQKKIVYSFEDSEDSDADKPIPPSKKPSAVVVNAPSTKTFEKKKENTDIPPSPSKTKETTSTTTDTKPIKSPSKSNKSTTPTTTTPITTEKKKIAQLEFESPIVSITAIDTEKKKDGNKDNKNKEKDKDSSPFDEMEIEESKSKTIMPNNNNNNKSKESSSSTTNSKNNTSMNDDLIFDDFAFSPIKSGSNKTTPSKSTSSPSKETTPIKTRSKTVESKFDDDSIFDSPDKKTTTTTASNTKTKTPPSKKDKFNHDIIFEESDTPLNRAIEDSIVKRSLSGLNNIDKDSKTTTTTTTEKKQKLKSDPFDTETEEETEDEGDEPLYKQQSSSFGSGSINPTATPTTPTKKPAATSTNATPTKKPNPFMYMNGRPTPPNKGSKPRPQGKENCLRGKVFLVSGVMDCFERDEMHDIIKRWGGKVAKSAVKLLNYLVSGKDVGEKKLEGAKKVGAKIITEDEFLEMINKTLPKPVSTTETTHISLPTPTPTPTPTPASSSSSSTTTTTTTTTTTTNSTGIKGPSLPVRSGSGGSSTGIKGPSLPVRSGSGGTTSSSPPLTFTSSPPTSTTTATTTTTSSPPISMASVIVPKSISTIPKGHDILWVEKYRPKVIEDIVGNPGIFQEFGKWLDQWNSTAPRDASKKNAVLLSGPPGIGKTSAALLICKQKGFEAIELNASDARSKSEIKRLLSGVSDNQNITKFFGTTNQDTGKDVQANKKIKTAIILDEIDGSSGNSDRGGIAEIIGLIKKSKMPFICLCNDYYSSKVTSLRNHCMDLKLRKPTLNQVSSRLLAIAKHEGMKVSSYMIEKVYTSSHSDIRQSINTLQMMSRSKRDYNNDNVTQSLQEKDFDISPFTAAELILREDNSNINKKLDYFFSDFSLVPLIIQENYLKTRPYGGGSQSKYNDCELISMAADALSDSDQFGRAIGKEMAWNLLPTYGVTSCIIPSGYIRGSPPMPLSFPSYLGKYSNASKQQRFVRELQLHMRSTSNTFVNRDETRLYYVPMLKHHLIQPLVQDDNDGIENVINVMDEYGLTEDDRNNIIELSTWGKEDPLKDVKTQVKSAFTRKFRSTSHAIYDVSLLSSKGSGGGGTNIAEGYEEVEGESQNQIEEEDEETEEKDSLPNLVKKSSVKSKSDTKPKSTKSKSTTTKSKKK

Gene
RFC1
Protein
Replication factor C subunit 1
Organism
Homo sapiens
Length
1148 amino acids
Function
Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.
Similarity
Belongs to the activator 1 large subunit family.
Mass
128.255 kDa
Sequence
MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAIETDAMIKKKTKSSKPSKPEKDKEPRKGKGKSSKK

Gene
Rfc1
Protein
Replication factor C subunit 1
Organism
Mus musculus
Length
1131 amino acids
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction.
Similarity
Belongs to the activator 1 large subunit family.
Mass
125.985 kDa
Sequence
MDIRKFFGVISSGKKPVNETVKNEKTKASEGTVKGKKGVKEAKVNNSGKEDASKPKQHSKKKRIIYDSDSESEETVQVKNAKKKSEKLSLSYKPGKVSQKDPVTYVSETDEDDDFVCKKAASKSKENGVSTNSYLGTSNVKKNEENVKTKNKPLSPIKLTPTSVLDYFGTESVQRSGKKMVTSKRKESSQNTEDSRLNDEAIAKQLQLDEDAELERQLHEDEEFARTLALLDEEPKIKKARKDSEEGEESFSSVQDDLSKAEKQKSPNKAELFSTARKTYSPAKHGKGRASEDAKQPCKSAHRKEACSSPKASAKLALMKAKEESSYNETELLAARRKESATEPKGEKTTPKKTKVSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLTFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKILDEDGLLDLIRTMPGKRSKYEMAAEAEMKKEKSKLERTPQKNDQGKRKISPAKKESESKKCKLTLLKNSPMKAVKKEASTCPRGLDVKETHGNRSSNKEECLLWVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKLASKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTSGAAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQSKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGEETAHMSLMDKSDLFFHDYSIAPLFVQENYLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSLLPTQAIYASVLPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTVNMDYLSHIRDALVRPLTSQGVEGAQHVIKLMDTYYLMKEDFENIMEVSSWGGKPSAFSKLDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDAVETDAMIKKKTRSSKPSKSEREKESKKGKGKNWKK

Gene
RFC1
Protein
Replication factor C subunit 1
Organism
Oryza sativa subsp. japonica
Length
1021 amino acids
Function
May be involved in DNA replication and thus regulate cell proliferation.
Similarity
Belongs to the activator 1 large subunit family.
Mass
110.9 kDa
Sequence
MSSDIRKWFMKAQDKNGGAAKPAGTTALAKKPVLSIPEKPSAAPSMAACDQDCSARRKTSKYFASKTEKEEDTSAGKGTGRGLPKRKLQKVSDELEDDMKPLPAKEVHKEEEDDDDDDFVAPSKRKTPVKPPPSKKLKGASTAEAHGKTGLDDDNEDKMDEDAKTPSKASGSGRGRGRGRGRGGRGAGAAHGKTIGLDDDGEEDKMDEDAKTPSKAAGRGRGGASGGRGRGGGGRGFMNFGERKDPPHKGEKEVPEGAPDCLTGLTFVISGTLDSLEREEATDLIKRYGGRVTGSISKKTNYLLADEDVGGVKSNKAKELGVPFLTEDGLFDMIRKSKPAKATVAKHQSDKNSEKQQKSPMKSSPVKVERRDGNQITTGKNISPKSNKGSASIDNQKVNIVDRGSLQWTEKYRPKVPNDIVGNQSMVKQLHDWLRSWEDQFLHSGQKGKGKKQADSGAKKAVLLSGPPGIGKTTTAKVVSQMLGLQAIEVNASDSRGKADSKIEKGVGGSTSNSIKELISNATLNYSNNRLKRPKAVLVMDEVDGMSAGDRGGVADLIASIKMSKIPIICICNDRYSQKLKSLVNYCLLLNFRKPTKQQMGKRLMEIAKKEGLQAQENAMEELAERVHGDIRMALNHLQYMSLSQSVVKYDDIRQRLNSSTKDEDISPFTAVDKLFGFNGGRLRMDERIDLSMSDPDLVPLIIQENYINYRPITVGKDDSGVKRMNFLARAAESIADADIVNVQIRRYRQWQLSQAACLSSSIVPAALMHGNREILEAGERNFNRFGGWLGKYSTTNKNIRLLEDAHSHILASQQANLDRESLRLDYLTLLLRQLTDPLKTMPKDEAVQKVVEFMDTYSLSQEDFDTIVELSKFKGHPNPMDGIQPAVKSALTKAYKQGSSSRVVRAADLVNIPGMKKPLKKRVAAILEPVGESLPEENGVASSEGDEEDSSDAENNDELVPGDTKPKLDLQSDKKKGIQVQLDLKSNGNGLNSKKMPAGRSKASGSAGKAAGGSGGKRKR

Gene
RFC1
Protein
Replication factor C subunit 1
Organism
Arabidopsis thaliana
Length
956 amino acids
Function
Plays a role as mediator of transcriptional gene silencing (TGS), DNA replication, DNA repair, hypersensitive response (HR) and telomere length regulation. Is required in meiosis for DNA double-strand break (DSB) repair during meiotic homologous recombination. May participate in the RAD51-mediated recombination intermediate repair process. Is important for lagging strand synthesis. Promotes meiotic recombination via a specific pathway for crossovers (COs) that involves the formation of double Holliday Junction (dHJ) intermediates.
Similarity
Belongs to the activator 1 large subunit family.
Mass
104.378 kDa
Sequence
MSDIRKWFMKAHEKGNGSAPKSTSSKAGPVKNAAETAPIKSEQASEDLETADRRKTSKYFGKDKTKVKDEKEVEAIPAKRKLKTESDDLVKPRPRKVTKVVDDDDDDFDVPISRKTRDTTPSKKLKSGSGRGIASKTVDNDDDDDGEDKETPLKSAGRGRGGRAAPGASTGGRGRGGGRGGFMNFGERKDPPHKGEKEVPEGTPDCLAGLTFVISGTLDSLEREEAEDLIKRHGGRITGSVSKKTTYLLCDEDIGGRKSEKAKELGTKFLTEDGLFDIIRSSKPVKKSLPERSNKGTEKICAPPKTSPQKEETRGKPLAKSSPKKVPPAKGKNKIIETSLPWTEKYRPKVPNEIVGNQSLVTQLHNWLSHWHDQFGGTGSKGKGKKLNDAGSKKAVLLSGTPGIGKTTSAKLVSQMLGFQAVEVNASDSRGKANSNIAKGIGGSNANSVKELVNNEAMAANFDRSKHPKTVLIMDEVDGMSAGDRGGVADLIASIKISKIPIICICNDRYSQKLKSLVNYCLPLNYRKPTKQQMAKRLMHIAKAEGLEINEIALEELAERVNGDIRLAVNQLQYMSLSMSVIKYDDIRQRLLSSAKDEDISPFTAVDKLFGYNGGKLRMDERIDLSMSDPDLVPLLIQENYLNYRPSGKDEAKRMDLLARAAESIADGDIINVQIRRYRQWQLSQSCCVASSILPASLLHGSREVLEQGERNFNRFGGWLGKNSTAGKNRRLMEDLHVHVLASRESSAGRETLRVDYLPLLLSRLTSPLQTLPKDEAVSEVVDFMNSYSISQEDFDTILELGKFKGRENPMEGVPPPVKAALTKKYNEMNKTRMVRVADMVQLPGVKKAPKKRIAAMLEPTVDSLRDEDGEPLADNEEGNGSDAEEDSEEATDGEKLESNLKNLNARGIQVELDLKGAGSSGSRKAAGKGRGRGKAADTSAEKKATGRGSGAKRKR

Gene
rfc1
Protein
Replication factor C subunit 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
934 amino acids
Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 1 is essential for cell cycle progression. It may associate with components of the DNA replication machinery and serve to enhance the efficiency of DNA replication.
Similarity
Belongs to the activator 1 large subunit family.
Mass
103.489 kDa
Sequence
MSNSDIRSFFGGGNAQKKPKVSPTPTSPKPKRSLKKKRIVLSDDEDGTIENSKVPASKSKVQKRNESEDISHSLPSIVHEDDKLVGSDGVSTTPDEYFEQQSTRSRSKPRIISNKETTTSKDVVHPVKTENFANDLDTTSDSKPVVHQTRATRKPAQPKAEKSTTSKSKSHTTTATTHTSRSSKSKGLPRFSDEVSQALKNVPLIDVDSMGVMAPGTFYERAATTQTPGSKPVPEGNSDCLSGISFVITGILETLTRQEATDLIKQYGGKVTGAPSVRTDFILLGENAGPRKVETIKQHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKKEQEEKKILETVARMDDSNKKESQPSQIWTSKYAPTSLKDICGNKGVVQKLQKWLQDYHKNRKSNFNKPGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASDTRSKRLLDEQLFGVTDSQSLAGYFGTKANPVDMAKSRLVLIMDEIDGMSSGDRGGVGQLNMIIKKSMIPIICICNDRAHPKLRPLDRTTFDLRFRRPDANSMRSRIMSIAYREGLKLSPQAVDQLVQGTQSDMRQIINLLSTYKLSCSEMTPQNSQAVIKNSEKHIVMKPWDICSRYLHGGMFHPSSKSTINDKLELYFNDHEFSYLMVQENYLNTTPDRIRQEPPKMSHLKHLELISSAANSFSDSDLVDSMIHGPQQHWSLMPTHALMSCVRPASFVAGSGSRQIRFTNWLGNNSKTNKLYRMLREIQVHMRLKVSANKLDLRQHYIPILYESLPVKLSTGHSDVVPEIIELMDEYYLNREDFDSITELVLPADAGEKLMKTIPTAAKSAFTRKYNSSSHPIAFFGSSDVLPMKGSAQREVPDVEDAIEAEDEMLEEASDSEAANEEDIDLSKDKFISVPKKPKKRTKAKAEASSSSSTSRRSRKKTA

Gene
RFC1
Protein
Replication factor C subunit 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
861 amino acids
Function
Component of the ATP-dependent clamp loader RFC complex for the POL30/PCNA homotrimer DNA clamp. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Replication factor C (RFC or activator 1) complex acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment.
Similarity
Belongs to the activator 1 large subunit family.
Mass
94.903 kDa
Sequence
MVNISDFFGKNKKSVRSSTSRPTRQVGSSKPEVIDLDTESDQESTNKTPKKMPVSNVIDVSETPEGEKKLPLPAKRKASSPTVKPASSKKTKPSSKSSDSASNITAQDVLDKIPSLDLSNVHVKENAKFDFKSANSNADPDEIVSEIGSFPEGKPNCLLGLTIVFTGVLPTLERGASEALAKRYGARVTKSISSKTSVVVLGDEAGPKKLEKIKQLKIKAIDEEGFKQLIAGMPAEGGDGEAAEKARRKLEEQHNIATKEAELLVKKEEERSKKLAATRVSGGHLERDNVVREEDKLWTVKYAPTNLQQVCGNKGSVMKLKNWLANWENSKKNSFKHAGKDGSGVFRAAMLYGPPGIGKTTAAHLVAQELGYDILEQNASDVRSKTLLNAGVKNALDNMSVVGYFKHNEEAQNLNGKHFVIIMDEVDGMSGGDRGGVGQLAQFCRKTSTPLILICNERNLPKMRPFDRVCLDIQFRRPDANSIKSRLMTIAIREKFKLDPNVIDRLIQTTRGDIRQVINLLSTISTTTKTINHENINEISKAWEKNIALKPFDIAHKMLDGQIYSDIGSRNFTLNDKIALYFDDFDFTPLMIQENYLSTRPSVLKPGQSHLEAVAEAANCISLGDIVEKKIRSSEQLWSLLPLHAVLSSVYPASKVAGHMAGRINFTAWLGQNSKSAKYYRLLQEIHYHTRLGTSTDKIGLRLDYLPTFRKRLLDPFLKQGADAISSVIEVMDDYYLTKEDWDSIMEFFVGPDVTTAIIKKIPATVKSGFTRKYNSMTHPVAIYRTGSTIGGGGVGTSTSTPDFEDVVDADDNPVPADDEETQDSSTDLKKDKLIKQKAKPTKRKTATSKPGGSKKRKTKA