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RBM38

Gene
RBM38
Protein
RNA-binding protein 38
Organism
Homo sapiens
Length
239 amino acids
Function
(Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.
Similarity
Belongs to the RBM38 family.
Mass
25.498 kDa
Sequence
MLLQPAPCAPSAGFPRPLAAPGAMHGSQKDTTFTKIFVGGLPYHTTDASLRKYFEGFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRSLQTGFAIGVQQLHPTLIQRTYGLTPHYIYPPAIVQPSVVIPAAPVPSLSSPYIEYTPASPAYAQYPPATYDQYPYAASPATAASFVGYSYPAAVPQALSAAAPAGTTFVQYQAPQLQPDRMQ

Gene
Rbm38
Protein
RNA-binding protein 38
Organism
Mus musculus
Length
237 amino acids
Function
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation.
Similarity
Belongs to the RBM38 family.
Mass
25.364 kDa
Sequence
MLLQPACSPSVFPRPSAAPSAMHGSQKDTTFTKIFVGGLPYHTTDASLRKYFEGFGDIEEAVVITDRQTGKSRGYGFVTMADRAAADRACKDPNPIIDGRKANVNLAYLGAKPRSLQTGFAVGVQQLHPTLIQRTYGLTPHYIYPPAIVQPSVVIPATPVPSLSSPYLEYTPASPAYAQYPPATYDQYPYAASPAAATSFVGYGYPAAVPQALSAAAPAGTTFVQYQAPQLQPDRMQ

Gene
rbm38
Protein
RNA-binding protein 38
Organism
Xenopus tropicalis
Length
219 amino acids
Function
RNA-binding protein that specifically bind the 3'-UTR of VegT transcripts, leading to maintain their stability and stimulate their translation, thereby playing a role in germ layer formation. VegT is a localized maternal determinant essentially required for endoderm formation. Also has some proneural function in the open neural plate and in the context of retinogenesis. May also act as a mRNA splicing factor. May play a role in myogenic differentiation (By similarity).
Similarity
Belongs to the RBM38 family.
Mass
24.074 kDa
Sequence
MHTVQKDTTFTKIFVGGLPYHTTDASLRKYFEVFGDIDEAVVITDRQTGKSRGYGFVTMSDRAAAERACKDPNPIIDGRKANVNLAYLGAKPRNLQSAFTIGVQQLHPAFIQRPFGLTPQYIYPPAIVQPSVVIPTPIPSLQSPYIDYNAATQAFTHYTTAAYEQYPYAASPATGYMGYGYTSAVQQPLSATTTTATTGAPPTAYIQYQPQQLQPDRMQ

Gene
RBM38
Protein
RNA-binding protein 38
Organism
Gallus gallus
Length
215 amino acids
Function
RNA-binding protein that specifically bind the 3'-UTR of some transcripts, leading to maintain their stability. Also acts as a mRNA splicing factor. May play a role in myogenic differentiation (By similarity).
Similarity
Belongs to the RBM38 family.
Mass
23.453 kDa
Sequence
MHTVQKDTTFTKIFVGGLPYHTTDSSLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRSIQTGFTIGVQQLHPAFIQRPFGLTPHYVYPQAIIQPSVVIPTPVQSIASPYIDYTAASQAYSQYTTAAYDQYPYAASPAAGFVGYGYTGAVQPPITASTPAAPATAFVQYQPQQLQPDRMQ

Gene
rbm38
Protein
RNA-binding protein 38
Organism
Xenopus laevis
Length
214 amino acids
Function
RNA-binding protein that specifically bind the 3'-UTR of VegT transcripts, leading to maintain their stability and stimulate their translation, thereby playing a role in germ layer formation. VegT is a localized maternal determinant essentially required for endoderm formation. Also has some proneural function in the open neural plate and in the context of retinogenesis. May also act as a mRNA splicing factor. May play a role in myogenic differentiation.
Similarity
Belongs to the RBM38 family.
Mass
23.747 kDa
Sequence
MHTVQKDTTFTKIFVGGLPYHTTDASLRKYFEVFGDIDEAVVITDRQTAKSRGYGFVTMSDRAAAERACKDPNPIIDGRKANVNLAYLGAKPRNLQSAFTIGVQQLHPAFIQRPFGLTPQYIYPPTIVQPSMVIPTPIPSLQSPYIDYNAATQAYTHYTTAAYEQYPYAASPATGYMGYGYTSPVQQPLSTTTGAPPTAYIQYQPQQLQPDRMQ