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RBBP8

Gene
RBBP8
Protein
DNA endonuclease RBBP8
Organism
Homo sapiens
Length
897 amino acids
Function
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:10764811, PubMed:10910365, PubMed:15485915, PubMed:16581787, PubMed:16818604, PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:20829486). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity).
Similarity
Belongs to the COM1/SAE2/CtIP family.
Mass
101.942 kDa
Sequence
MNISGSSCGSPNSADTSSDFKDLWTKLKECHDREVQGLQVKVTKLKQERILDAQRLEEFFTKNQQLREQQKVLHETIKVLEDRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKRRQPYNAIFSPKGKEQKT

Gene
Rbbp8
Protein
DNA endonuclease RBBP8
Organism
Mus musculus
Length
893 amino acids
Function
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations.
Similarity
Belongs to the COM1/SAE2/CtIP family.
Mass
100.831 kDa
Sequence
MSISGSGCGSPNSADASNDFKELWTKLKEYHDKEVQGLQVKVTKLKKERILDAQRLEEFFTKNQQLRDQQKVLQETIKILEDRLRAGLCDRCAVTEEHMHKKQQEFENIRQQNLKLITELMNEKNTLQEENKKLSEQLQQKMENGQQDQVAELACEENIIPDSPVTSFSFSGINRLRKKENLHVRYVEQTHTKLERSLCTNELRKISKDSAPAPVNSEEHEILVADTCDQNHSPLSKICETSSYPTDKTSFNLDTVVAETLGLNGQEESEPQGPMSPLGSELYHCLKEDHKKHPFMESARSKEDSLRFSDSASKTPPQEFTTRASSPVFGATSTVKAHLGLNTSFSPSLLDIGKKNLLKTAPFSNIAVSRSEKVRSKSEDNALFTQHSLGSEVKVISQSFSSKQILTNKTVSDSVDEQCSADHMNTTVADKYLVPLKSLGGKASKRKRTEEESEHAVKCPQACFDKENALPFPMENQFSMNGDHVMDKPLDLSDRFAATQRQEKNHGNETSKNKLKQATIYEALKPIPKGSSSGRKALSGDCMPAKDSWETYCLQPRSLQSSSKFSPDQKTPLQIKEENPVFKTPPCSQESLETENLFGDVKGTGSLVPTKVKSRAVHGGCELASVLQLNPCRVAKTKALPSNQDTSFENIQWSVDPGADLSQYKMDVTVIDTKDSSHSRLGGETVDMDCTLVSETVLLKMKKQEQKERSPNGDIKMNDSLEDMFDRTTHEEYESCLADSFSQVPDEEELPDTTKKTNIPADKQDGVKQKAFVGPYFKDKERETSIQNFPHIEVVRKKEERRKLLGHTCKECEIYYADLPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCLERGYIKEDLDLSPRPKRRQPYNAVFSPKGKEQRT

Gene
Rbbp8
Protein
DNA endonuclease RBBP8
Organism
Rattus norvegicus
Length
893 amino acids
Function
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity).
Similarity
Belongs to the COM1/SAE2/CtIP family.
Mass
100.705 kDa
Sequence
MSISGSSCGSPNSTDISSDFKELWTKLKEYHDKEVQGLQIKVTKLKKERILDAQRLEEFFTKNQQLRDQQKVLQETIKILEDRLRAGLCDRCAVTEEHMHKKQQEFENIRQQNLRLITELMNEKSALQEENKKLSEQLQQKMESGQQDQVAELECEENIIPDSPITSFSFSGINRLRRKENLHVRYVEQTHTKLEHSACTSELRKFSKGSTPAPVNSEEHEILVADTCDQSHSPLSKICGTSSYPADKLSSNLDAVVAETLGLDGQEESEPQGPVSPLGNELYHCLKEDHKKQPFMESAIRNEDNVRFSDSASKAPPRELTTRGSSPVFGPTSTVKTHLGLKTSFSPSLLDSGKKNLLSTAPFSSISVSRSEKVRSKSEDNALFTQQSAGSEVKVISQSFPSKQILTSKNVSDSVDEQGGADHMKDAVSDKHLVPLKSLGGKASKRKRTEEEGEHAVHCPQTCFDKENALPFPMENQFPVNGDHVMDKPLDLSDRFAANQRQEKNHGDETCKHKLKQVTIYEALKPVPKGSSSGRKALSGACTLAQDSAETYCLQQRTLQCSSKFSPDHNTQLQIKEENPVFKTPPRSQESLETENLFGDVKGIGSLVPIKVKGRSAHGGCELASVLQLNPCRVAKTKSLPSNHDMSFENIQWSVDPGADLSQYKMDVTVIDTKDSSHSRLGGETVDMDCTLVSETMLLKMKKQEQREKSPNGDIKMNDSLEDMFDRTTHEEYESCLADNFSQVPDEEELSDTTKKPNIHGDKQDGIKQKAFVEPYFKDKERETSIQNFPHIEVVRKKEERRKLLGHTCKECEIYYADLPAEEREKKLASCSRHRFRYIPTNTPENFWEVGFPSTQTCLERGYIKEDLDPCPRPKRRQPYNAVFSPKGKEQRT

Gene
rbbp8
Protein
DNA endonuclease RBBP8
Organism
Xenopus tropicalis
Length
867 amino acids
Function
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA.
Similarity
Belongs to the COM1/SAE2/CtIP family.
Mass
99.332 kDa
Sequence
MNISASTCGSPSSSESLPAGDLFKELWSKLKECHDKELQELLLKINKLKKQRCLDAQRLEEFYTKNQHLREQQKTLHDTIKVLEDRLRAGLCDRCTVTEEHMRKKQQEFENIRQQNLKLITELMNDKNALQDENKRLSEQLHNMQKSRWKSDEENPADTGEGEDGVIPDSPLSTFSLSMVSRMRRKKDNKHIRYSEKAPEDTLTLERKITCIPSQGSAEKNASHSSHRRKGEDILVAETLELSPLPNGKSKRKKVYLCSKTSIAFASILLVLLHLFAEQLHSWMNNLSQVSKSLRWCLPLKGNNKQGYIEYLFRFTEGSMEESQGNDDDGWNTKEASPVFGGPARNIRRSAEMDCISPPLPVGLNSKLISKCSRNPSDFLFNSVQAKAEDGAQATRLCLGKETDSVISQCSSNGQGVLRCSPNKSVPGGAQMGKDILDSEHHKQMANRYGKRKNAEAEQEESCESSFDKENNIPIKDIGSERHSMLDKPLDLSDRFSVLRPQDRSHGSSRGRTKQTFALVPEKPDPKKPLHIDLREDLYHQTKQKKVFVSGLVERSAFNLHEDKEVTEEGNQLFDDLEIETVHEPKRNARSVHRGVQPTSVLQPNLHMVQACPESQQGKPPIDNMQWSIDPGADLSQYEMDMTMEDSKGGSPAKPELEDMDYTYVSESFLLKMKKGDPGDSEDESKGQDSFEKMFDKSEYGEYVLCIKDRSPSQSCKERNDLSSMVCKNIYTHSVRFDRVKKQKAFVEPYFQRPEQKKPAMDFPHIEVVRKKDERRKMLGHTCKECELYYADLPEEERAKKLASCSRHRFRYIPPSTPENFWEVGFPSTQTCQDRGYIKEELSPCQRPRRRQPYNAKFSSKIKEQKT

Gene
rbbp8
Protein
DNA endonuclease RBBP8
Organism
Xenopus laevis
Length
856 amino acids
Function
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA.
Similarity
Belongs to the COM1/SAE2/CtIP family.
Mass
98.292 kDa
Sequence
MSITASTCGSPSSSESLPNGDLFKELWSKLKECHDKDLQELLMKIGKLKKERCLDAQRLEEFYTKNQHLREQQKTLHDTIKVLEDRLRAGLCDRCTVTEEHMRKKQQEFENIRQQNLKLITELMNDKNALQDENKRLSEQLHDMQKNRHRRKSDEENPADTGDGEDGVIPDSPLSTFSLSMVSRMRRKKENKHVRYTEQTQEDALTFDRKISSGTRPQISTQVNMRKGEDVLVAETLELAPLPNKYEVCTEKPVFNLATVVAETLGLDAMEESQSQSVFNQPGITCAPLFHKSEDSSPRQVKVEFTEGSMEGFQTNDDDTEWNRREASPVFGEPVRNIRRGTDMDCSSPPLPVGLSSKLKSHCSRNAPDFSVHAKAEDGALLTRLSHCIETDSVISQCSSNRQDVLRPSPNKSDAQMGKYIFDSEQHKQTGNRYGKRKNAEAEQEESCESSFDKENNIPLKDISGARHSMLDKPLDLSDRFSVLRPQDRSHESSSRTKLTISLVPEKPDTKTILHIDLKENLHQQTRQKKVFVSGLVEHSAFNLHEDNEVTEEDNKPFHDSETEIMCHVPKRKPRAVHRGVQPTSVLQPNLHMVHACLESQGRPPIDNMQWSIDPGADLSQYEMDMTMEDSKSGSPAKPELEDMDYTYVNESCLLKLKMGDPDDSEAESKDQDSFGEMFDKTEYGEYASYIKDKSPSQSISCKERSDIPSIENKKITSEKEHESKGEPYQKQKAFVEPYFQRPERKKPAIDFPHIEVVRNKEERRKMLGHTCKECELYYADLPEEERAKKLASCSRHRFRYIPPSTPENFWEVGFPSTQTCKDRGYIKEELSPCQRPRRRQPYNAIFTSKIKEQKT

Gene
RBBP8
Protein
DNA endonuclease RBBP8
Organism
Bos taurus
Length
757 amino acids
Function
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity).
Similarity
Belongs to the COM1/SAE2/CtIP family.
Mass
85.265 kDa
Sequence
MNLSGSSCGSPSSADVSNDFKDLWTKLKEYHDKETQGLQVKVTKLKKERILDAQRLEEFFTKNQQLREQQKVLHETIKVLEDRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNEKNTLQEENKKLSEQLQQKIENDQPHKATDLESEEDVIPDSPITTFSFSGTNRLRRKENLRVRYIEQTHAKLEHSGCAHELRTVPKSSAHPQHKPKESEILVADTCDQSQAPVAKPHGKSSYTPDNLATVVAETLGLCVQEESESRGPQSPLGDELYHCLEGDHKKQAFEECRRNSEDNLRFSDSKTPFQEELTTRVSSPVFGAPSNVKSSLGLNTSLSPSLLETGKKTHLKTVPLSNTSAPGPEKPRSKSEDGTLITHHHLGTEVNKIPSQSSSNKQMLINKNTSEPISEQGNIGHSKDTDRDKHVVPLKSLGGRTKRKKIEEESEDEVICPQASFDKENAFPFPLDSHSSMNGDYVMDKPLDLSDRFSAIQRQEKSQGCENSKIRFRQVTLYEALKPIPRDSSSSRKALSGSCGLTKDSPEEPCLQESLFQSLSKSPDNKTLLQIKEENPVFKIPLRPRESFETENLFDDTKGAGSHEPIKIKTRSVRGACEVASVLQLNPCRIAKTKSLQNNQDVSFENIQWSIDPGADLSQYKMGVTVDDTKDGSQSRLAGETVDMDCTLVSETMLLKLKKQEQKGEESPNGERKMNDSLEDMFDRTTHEEYESCLAESFPQVADEEKELSTTTKKPNISW

Gene
rbbp8
Protein
DNA endonuclease RBBP8
Organism
Danio rerio
Length
651 amino acids
Function
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA.
Similarity
Belongs to the COM1/SAE2/CtIP family.
Mass
74.39 kDa
Sequence
MSITPADLSPASSSDHREKLQELLTAVRDLHDTALQELQAKIAKLKKERCLDAQKLSEFHSKNQHLREQQKIQQEKIRQLEDRLRSGPCDRCTVKEKQIKKTNTELEDNNQRNLSVISELEAERKTLTDENRRLSLELERLRRSGSPQNTSSEAEEGMIPDSPLRPLSLPVASKMKRRKEQNHVRYTETPLSLSHPESRQREQSVAFGCNGKGVLVAETCEMDATSVAERDNKRHFRIVVPETCRPDVYPEQVDDVDDDDLHIPSHTEQNQKPELRDCTNILIAGQNDDSPLILRCRPLASQDHQSSIDDVLRTPANSSTCVLTKGKRKHSNGAKKDREISDCRLDADETDIKGIIFASTPANGRLQSKNQETSEIETTQDSKKKCLDGHTPRKSLVQNHHAPFPYDQSWSVDPGADLGQYDTESSPQPEHQARTDLETLDTDCTFVSHSLLLRGQKTTGQSQTTGIGQKANDSLADIFDKTGYGEYESCPQDDSIDLKQDSVYEEEREEDDPEEKPEAAVVFRRPADRKPLVSDSDKSSRNKSFACVEVVRKKDERRKLKGHYCKECEVYYADLPEEEREKKLTSCSRHRYRYIPPSTPENFWEVGFPSTQTCVERGYIKEDEQPDVRIRRRRPYLAMFSPKAKSQKKKH