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RB5134

Gene
RB5134
Protein
dITP/XTP pyrophosphatase
Organism
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Length
208 amino acids
Function
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
22.802 kDa
Sequence
MNRMFDLVLGTGNAKKLVELRMMLPEETIALTALSEIENAIDVVEDGETFSANAAKKATEQAKHLERWVLAEDSGLSVDALKGAPGVYSARYAGTHGDDEANNEKLLRELTDVPMDRRGAQFNCHLCLSDPDGNVRLAESGICRGRIATERSGGAGFGYDPLFVIPEYHKTFGELNLTVKRALSHRSRALRLFIPQLLRLVQSNSTSA