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RAD18

Gene
Rad18
Protein
E3 ubiquitin-protein ligase RAD18
Organism
Mus musculus
Length
509 amino acids
Function
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.
Similarity
Belongs to the RAD18 family.
Mass
57.412 kDa
Sequence
MEVLAEPRWPPGLAVMKTIDDLLRCGICFEYFNIAVIIPQCSHNYCSLCIRKFLSYKTQCPTCCVAVTEPDLRNNRLLDELVKSMNFARTHLLQFALESPPISPVSSTSKKVVVKVHNADAAQHPVKQANRLMDKFLIRETGDCVFELLGKENERKFSPQKELSTSAEIKETSLLGKPVLGLSDANGPVTPSTSTMKLDTKVSCPVCGVSIPENHINKHLDSCLSREEKKESLRSSAHKRKPLPKTVYNLLSDRDLKKKLKQYGLSVQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVQEIESMEKTRMRLEASKLNENVMVFTKNQTEKEIEEVHSEYRKKHQNAFQLLVDQAKKGYKKTGRVSQAAAMRTDEPAETLPSMRTDEPAETLPSMRTDEPAETLPLMRADEPAETLPSECIAQEDNVSFSDTVSVTNHFPQPQLDSPGPSEPERPDDSSSCTDILFSSDSDSCNRNDQNREVSPQQTRRTRASECVEIEPRNKRNKN

Gene
RAD18
Protein
E3 ubiquitin-protein ligase RAD18
Organism
Homo sapiens
Length
495 amino acids
Function
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.
Similarity
Belongs to the RAD18 family.
Mass
56.223 kDa
Sequence
MDSLAESRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPVASRQSLKQGSRLMDNFLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAPDPSEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVREIENIEKTRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSKLDSPEELEPDREEDSSSCIDIQEVLSSSESDSCNSSSSDIIRDLLEEEEAWEASHKNDLQDTEISPRQNRRTRAAESAEIEPRNKRNRN

Gene
RAD18
Protein
Postreplication repair E3 ubiquitin-protein ligase RAD18
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
491 amino acids
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Similarity
Belongs to the RAD18 family.
Mass
55.586 kDa
Sequence
MNSNPFTKNLQNVTDPSDWEPTKLPNLKELDSLQRCYICKEFLKAPVITSCNHTFCSHCIREYLIVNSHCPLCKAEQFESNLKRVILLEEIVLCFSKFRPILLELLKKEESNEAYDKNRSPFSEIPSKDEDSRKRSSPDQEVIEISSDESNSLELSEASNDVPKKKIKAEINSNSRNAIPTRNEMVECPICAEVMSADLLQTQHIDYCLSGKSQPSSSRSAGNSSSRYQSMKRRQPNKTNNGISSFFKPADNKPIMAGAGKLDLSKTDNQNFYFDEVSKHHHNDIKKLPKLDFSSLTTPKLKEKLSHLKLPVQGTRIQLELRYNQYYILFNSNLDSNHPLSEKVLKQKLNQWELSHSAFTNQGSTSTLFNNGSPAVKSITDKNFSVKEWLDANRNEYKSLVKAARASIKKASTKNVTSSISIDTEAINTHSVGGQHLNERSEYRSEANLIEPIDDGASEEIQQNEISNLNFKKDIANSPLFVKDTLNESHS

Gene
RAD18
Protein
Postreplication repair E3 ubiquitin-protein ligase RAD18
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
487 amino acids
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR. The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
Similarity
Belongs to the RAD18 family.
Mass
55.23 kDa
Sequence
MDHQITTASDFTTTSIPSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKKSKPNEQMAQCPICQQFYPLKALEKTHLDECLTLQSLGKKPKISTTFPTESNPHNKSSSRFKVRTPEVDKSSCGETSHVDKYLNSMMSAEHQRLPKINFTSMTQSQIKQKLSSLGLSTNGTRQNMIKRYNHYEMLWNSNFCDSLEPVDEAELKRQLLSWDVSHNKTPQNSSNKGGISKLMIMKSNGKSSSYRKLLENFKNDKFNRKGWMVMFRKDFARLIREAKMKIKTGSSDSSGSVGHSNDGDGVEKVQSDQGTEDQQMEKDQDTVINEDRVAGERNLPNEDSTDADLSRELMDLNEYSKDPPGNN

Gene
RAD18
Protein
Postreplication repair E3 ubiquitin-protein ligase RAD18
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
443 amino acids
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Similarity
Belongs to the RAD18 family.
Mass
49.688 kDa
Sequence
MSIQPGQVVTDPSDFAGTTIPELADLDSLLRCHICKDMLQTPVLTQCGHTFCSLCIREYLNKESRCPLCLAELRQNMLQKEFLVGELAACYMELRARLLETVRIPPKKVAEVVQNNSPIELDSDGEVEIIESCTGAVPGSKRGSPQVEEVEAAAKRQRTKQNGIQYMLQKKPKAVGEKVPCPICNRLYNKEFLERVHLDECLMMGTLRESGESDITVIEQQSYTAEPDSKNSHVAERRGESPVDEVVTHKESYLGSGLRVTKSRLPKLHFTSLSTSQLKQKLSELGLPTAGSRQQMINRYNHYELLWNSNFLDSIQPVGEGELRRSLLSWEATRNTDTPISSGVSSSITNMLKTNNSASTLLKSFKTDKFDKSAWSRLHGKEFRRLIRAAKKSMLEQDRGEAITAQNNELSTKASVDMESTSFRNDTNDTIDTVTDEVHEDLK

Gene
RAD18
Protein
Postreplication repair E3 ubiquitin-protein ligase RAD18
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
427 amino acids
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Similarity
Belongs to the RAD18 family.
Mass
48.688 kDa
Sequence
MKLSVPETISNPRDFLHTSVPQLTDLDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDLTESMLQKEFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEADTSVGTKRGTPDSPSLSSVSTKKRKHDGITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELEGSHIDECLNKGSSLERSDSFEILDERTPSPSMESSHQPLEEKTSLPSSHLLEVKEKKDITYHNERYLNSGLLQQKENRLPRLDFQSLSMTQLKQKLASLALPSNGTKQQMVARYKHYEMLWNSNFLDSIDPVDENELKRRLSSWEAKHNTDHSSDSNSITNLLRGNKRTNAISAMIKLFKSDRFDRKGWMRHHTSTFKALKLEAQRSDKLAKMKKEELSQKSDANSEVSSEPILKIDQTSENN

Gene
rad18
Protein
Postreplication repair E3 ubiquitin-protein ligase rad18
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
418 amino acids
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Similarity
Belongs to the RAD18 family.
Mass
46.205 kDa
Sequence
MEQTFDLPDSTDWLETPLSLVSPLESSLRCQVCKDFFDNPVITSCSHTFCSLCIRRCLSTEGKCPACRSSDQELKLRRNWAVQELVEAFQNARPSMLELARKAANSRLDGGYVTGQPAAKKRKVDQEDGPDASGSEGIRTRSQSRRGNSQAEPVVVDAIEDDQDKEYIPEDGLVACPICGRRMKNEAVFQHLDICTGDPAPLKQASFGSLQPMSPASRKSKDVTDKPPERLPTINYSLLKDNVLRKKLKDLGIPNWGPRPLLQRRHTEWMNLWNANCDSKAPKSKRELLHELAVWERTQGGHAAPSSESSNTVMRKDFDAAAWSNNHGDEFKRLIANARKRKDAVIRTTIPQAAPARDGTSTASAPEQSTEMSTPPEVAERLQTQTVPEGTSVATIAENETGTIQTPNITQVVSSPPE

Gene
RAD18
Protein
Postreplication repair E3 ubiquitin-protein ligase RAD18
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
411 amino acids
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Similarity
Belongs to the RAD18 family.
Mass
46.771 kDa
Sequence
MDVLTSAADFKKSKVPQLQELDDLLRCHICKDFLKNPVLTPCGHTFCSLCIRGYLSNEPKCPLCLHELRESMLRSEYLVNEITETYKAARQRLLDELNSLETNQDNSVIEVVSDKEPSLLQIDDDVNENSNHITVNDTSDIIDEDNEIQITGTKRTARTILNGSRPTKAAKISDMFTTRKAKTEEKAPCPICSQLFPIRYLERTHLDECLTKPPTSSPPIKQSRLSPKPSESVSHVKRYLNSTNTSTQQRLPKLNFAKMTTSQLKQKLASLSLPVSGTRANMVARYNYYEMLWNSNFIDSINPVSESELRRQLMSWDASHNGNNNSSNGGTNTISQLMKMNSKNKGKEYEKLLKDFKKDSFDKKGWMLLHKNSFNRLLCDAKKTRRKTENETLMTSQSPRESSTQTELSAT

Gene
RAD18
Protein
Postreplication repair E3 ubiquitin-protein ligase RAD18
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
378 amino acids
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Similarity
Belongs to the RAD18 family.
Mass
42.482 kDa
Sequence
MNLKDITDPSDFKTTKLPALAELDILKRCYICKDLLNAPVRTQCDHTYCSQCIREFLLRDNRCPLCKTEVFESGLKRDPLLEEIVISYASLRPHLLRLLEIEKVESKQEVDREKSANESASNGNRNVNNDVDETVRVKDQSNADELGEEKGQAQHGEQVNEQTTEVISLLSDDEENGSDSLVKCPICFERMELDVLQGKHIDDCLSGKSTKRTPTDILSPKAKRPKQITSFFKPTIDTKTPSPPTSKASTTPTATPTTTLLKANVSSPSPVAQSTVHKGKPLPKLDFSSLSTQKIKAKLSDLKLPTTGSRNEMEARYLHYYVIYNANLDSNHPVKESILRQQLKQWEMVQHQPSFGDAEWKGAETGNWKELIARARSN

Gene
RAD18
Protein
Postreplication repair E3 ubiquitin-protein ligase RAD18
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
344 amino acids
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Similarity
Belongs to the RAD18 family.
Mass
39.535 kDa
Sequence
MNSDIPDPSDWIDSKLSGLKDVDETLRCHICKEFFTAPMITGCGHTFCSLCIQRYLTNTSQRCPTCMQEQQISQLRKNVTVETLVEHFSAQRATILRVVKEAAKQPIPEVVEPPSSPDLDDGRRRSGRKRTRTNYTETLVSSDDIQVECPVCQAMLPGAAINRHLDNNCNDTGANGGNWLGTKKKTKPLRKIQRVNQASESVANVRRKLQDEGLSTSGSKQTLFRRYDEWVTLWNANVDNKTPRSKSDIKDDLRRWETTVVANENAQPVKMTIKNIDDRQWVQKHKEDYDYLIEQARKSILKKKQEKEKEQQQQQEGHQKAVDRREDNEPDMKRSETEGYQVVS