Protein
Multidrug transporter QDR2
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Function
Multidrug resistance transporter involved in resistance to the antifungal drugs miconazole, tioconazole, clotrimazole, and ketoconazole; as well as to quinidine (PubMed:23629708, PubMed:27148215). Decreases the intracellular accumulation of clotrimazole in and plays a role in the extrusion of this antifungal from preloaded cells (PubMed:23629708, PubMed:27148215).
Similarity
Belongs to the major facilitator superfamily. CAR1 family.
Sequence
MMEDQQSLHSFISDYDQRSHAVEKYDGPDLSEVDSEDNDKMIKTNEDEAVKEPIYRTRSNQTEPDIANAPPYSRFDAKYKMALVLQCAYTGLFSTMAGAIYYPVLSVIEKQFHITEELVNITVVVYFIFQGIAPTLMGGLADSLGRRPVVLFAVTVYFGACIGLACAQTYAQIVVLRCLQAAGISPVIAINSGIIGDVTTRAERGGYVGYISGFQVLGSAFGALIGAGLSSRWGWRSIFWFLAIGSGVCLVFSIIMLPETKRTIVGNGSVTPRNYLNRAPLLMFPLIRRKLHLDDPEYETLEPRTQLSLLAPLSILKVKEISILLVTAGIQFATWSTHQTALSTVLSKNYHLSVAKIGLCYLPTGICTLISIVTSGRYLNWSYRRRFAKHKVWLKEQEEILVKENGYSREEVQNIINNDPKYVFNLVQTRLHAAFVTLLLSSSGFVAFGWCIDVKAPLASVLVMSGFASLFSNCILTFSTTLIVDIFPSKTSTATGCLNLFRCLLSALFIGCLSKMATSMTYGGVFTFLGALTALSACPLFYLLKNGREITLKRKRKEDASRAFALSVANEKAEAEGKAEESR