Protein
Trans-3-hydroxy-L-proline dehydratase
Organism
Paracoccus denitrificans (strain Pd 1222)
Function
Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts t3LHyp to L-proline, which would allow P.denitrificans to grow on t3LHyp as a sole carbon source. Displays neither proline racemase activity nor 4-hydroxyproline 2-epimerase activity.
Similarity
Belongs to the proline racemase family.
Sequence
MRTSRVVHVVSCHAEGEVGDVIVGGVAPPPGETVWDQSRWIARDETLRNFVLNEPRGGVFRHVNLLVPPKDPRAQMGWIIMEPADTPPMSGSNAICVATVLLDTGIIPMQEPITRMVLEPPGGLIEVEAECRGGKAERIRVRNVPSFADRLDARIEVEGLGTITVDTAYGGDSFVLVDAASVGMRIAPDQARDLAEMGVRITRAANEQLGFRHPANDWSHISFCQFTDPLSERDGVLYGRNAVAIRPGKIDRSPTGTGCSARMAVLHARGRMKPGDRFVGRSIIDTEFHCSIADEVELNGKRAIRPIISGRAWVIGTKQLMVDPDDPFQNGYRLSDTWPMDL