Protein
Succinate dehydrogenase assembly factor 2, mitochondrial
Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)
Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Similarity
Belongs to the SDHAF2 family.
Sequence
MSAPRILHRVARPVPSSISTITRLNRQFGTTALRLKDGSDEASPEVKAHRANQANKAPNQFVPNTTSTMTKDFVNVGQKPAPPEMLNSANPNYRPSDPYPGRIEHFTGGRQDNGAQKPELGVGEMEGITFKVEPLKRVGEELATKRARLLYQSRKRGILESDLLLSTFADVYLGKMNYDQLVEYDSFLDENDWDIYYWATQDSPEEISPSTPKEDTITETWKESGAKSGEWAQTIGAFRAAYRPVPSRWQNSEVLALLREHVRDKSATGFEKAKNKKTGGGGGLGRMPDVQVFNSGHIVHRRHVLRMLYI