Protein
Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Organism
Drosophila pseudoobscura pseudoobscura
Function
Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Essential for viability. Involved in glycosaminoglycan synthesis and the subsequent signaling. May be involved in hh and dpp signaling by controlling the sulfation of heparan sulfate (HS) (By similarity).
Similarity
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Sequence
MGDGQAGSVININGSASGQQAPTSNSPTLTRKSSSSELPPELRILCFDLTHYNQTTQFLLSCAGVFILYILYGYLQELIFTVEGFKPFGWFLTLVQFGYYIGFGLVERRLEAYRSGRRSLWNVEPAPRCIPMKTYLVLAALTLGTMGLSNSSLGYLNYPTQVIFKCCKLIPVLVGSILIQGKRYGPLDFAAASCMCIGLAWFTLADSQMTPNFNLLGVAMISGALLCDAAIGNVQEKAMKEHKAPSSEVVFYSYGLGFVYLFVIMLVTGNFFSGFAFCLEHPLQTFGYGFLFSLSGYLGIQFVLALVRSSGAPIAATVTTARKAVTIAFSFVLFSKPFTVQYLWSGLIVVLGIYLNVYSKKNKLTFADIRSRFKQFGFRLARSPSRKFLVEV