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PYM1

Gene
PYM1
Protein
Partner of Y14 and mago
Organism
Homo sapiens
Length
204 amino acids
Function
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
Similarity
Belongs to the pym family.
Mass
22.656 kDa
Sequence
MEAAGSPAATETGKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEATAPVTPSRPEGGEPGLSKTAKRNLKRKEKRRQQQEKGEAEALSRTLDKVSLEETAQLPSAPQGSRAAPTAASDQPDSAATTEKAKKIKNLKKKLRQVEELQQRIQAGEVSQPSKEQLEKLARRRALEEELEDLELGL

Gene
PYM1
Protein
Partner of Y14 and mago
Organism
Bos taurus
Length
203 amino acids
Function
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
Similarity
Belongs to the pym family.
Mass
22.663 kDa
Sequence
MATPYVTDETGGKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEATAPITASRPEGGEPALSKTAKRNLKRKEKRRQQQEKGEAEALSRTLEKVSLGETAQVPSAPQASRAAPTAASDQPDSAATTEKAKKIKNLKKKLRQVEELQQRIQAGEISQPSKEQLEKLARRRALEEELEDLELGL

Gene
Pym1
Protein
Partner of Y14 and mago
Organism
Mus musculus
Length
203 amino acids
Function
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
Similarity
Belongs to the pym family.
Mass
22.69 kDa
Sequence
METASTPEATGTGKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEATTPVTPSRPEGGETGLSKTAKRNLKRKEKRRQQQEKEAEALSRTLDKVSLGDTAQIPSALQGPQATPLAASDPSDSAATTEKAKKIKNLRKKLRQVEELQQRIQAGEVSQPSREQLEKLARRRVLEEELEDLELGL

Gene
pym1
Protein
Partner of Y14 and mago
Organism
Xenopus tropicalis
Length
200 amino acids
Function
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
Similarity
Belongs to the pym family.
Mass
22.854 kDa
Sequence
MATPYVTDESGKYIAATQRPDGSWRKQRKVKEGYVPQEEVPVYENKYVKFFKSKPSLPPGLSETDASTGKTQQPSKPDADTTLSKTAKRNMKRKEKRKQEKGEREQVEDARQDLERVNISETPVQKNLTSAHKNGSASSDNPAAEKAKKIKNLRKKLRQVEELQQKIDSGEIKEPSKEQLEKLSRRKALEEEIEDLELDL

Gene
pym1
Protein
Partner of Y14 and mago
Organism
Xenopus laevis
Length
199 amino acids
Function
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
Similarity
Belongs to the pym family.
Mass
22.553 kDa
Sequence
MAAPYVSDDSGKYIASTQRPDGSWRKQRKVKEGYVPQEEVPVYENKYVKFFKSKPSLPPGLCEADGTTGQAQPSKPDADASLSKTAKRNLKRKEKRKQEKGEREQVEETRQDLERVNISDTPVQKNVTSAHKNGSASSDNSAAEKAKKIKNLRKKLRQVEELQQKIDCGEIIQPSKEQLEKLARRKALEDEIEDLELDL

Gene
pym1
Protein
Partner of Y14 and mago
Organism
Danio rerio
Length
194 amino acids
Function
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
Similarity
Belongs to the pym family.
Mass
22.066 kDa
Sequence
MATPYVTDESGKYIAATQRPDGSWRKPRRVRDGYVPQEEVPVYENKFVKFFKSKPELPPGVCVETPPQTQTQPSDAAGLSRTAKRNMKRKEKRRQQGQETKSEPELQPEPELQPEPEPQGLSQQMQQLELSASQGPGAADSARRLKNLRKKLRQVEELQQRVLSGELKPSQEQLDKLGRAQALREELQQLEAHS