Protein
Poliovirus receptor homolog
Organism
Chlorocebus aethiops
Function
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell (By similarity).
Similarity
Belongs to the nectin family.
Sequence
MARTMAAAWPPLLLTLLELSWPPPGTGDIIVQAPTQVPGFLGDSVTLPCYLQVPGMEETHVSQLTWSRHGESGSMAVFHQTQGPNYSEPKRLEFVAARLGTELRDASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGKPVPVARCVSTGGRPPAHITWHSDLGGMPNTSQAPGFLSGTVTVTSLWILVPSSQVDGKSVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLSQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTFICNVTNALGARQAELTVQVKEGPPSEPSGMSSNIIIFLILGIVILLTLLGIGVYFYRSRCSREFLWCHHLSPSSEEHASASANGYISYSDVSREASSSQDPQTEGTR