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PVR

Gene
PVR
Protein
Poliovirus receptor homolog
Organism
Chlorocebus aethiops
Length
417 amino acids
Function
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell (By similarity).
Similarity
Belongs to the nectin family.
Mass
45.465 kDa
Sequence
MARTMAAAWPPLLLTLLELSWPPPGTGDIIVQAPTQVPGFLGDSVTLPCYLQVPGMEETHVSQLTWSRHGESGSMAVFHQTQGPNYSEPKRLEFVAARLGTELRDASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGKPVPVARCVSTGGRPPAHITWHSDLGGMPNTSQAPGFLSGTVTVTSLWILVPSSQVDGKSVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLSQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTFICNVTNALGARQAELTVQVKEGPPSEPSGMSSNIIIFLILGIVILLTLLGIGVYFYRSRCSREFLWCHHLSPSSEEHASASANGYISYSDVSREASSSQDPQTEGTR

Gene
PVR
Protein
Poliovirus receptor
Organism
Homo sapiens
Length
417 amino acids
Function
(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.
Similarity
Belongs to the nectin family.
Mass
45.303 kDa
Sequence
MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR