Protein
Proteasome inhibitor PI31 subunit
Organism
Rattus norvegicus
Function
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity).
Similarity
Belongs to the proteasome inhibitor PI31 family.
Sequence
MAGLEVLFASAAPAMTCPQDALVCFLHWEVVTNGYYGLGTGDQPDPNDKKSELLPAEWNSNKELYALRYESKDGARKLLLKAVSVENGMIINVLEHGTQQVADLTLNLDDYIDAEDLSDFHRTYKNSEELRSRIRSGIITPIHEQWEKVRLSSPPREFPPATAREVDPLRISSHHPHTSRQPTWRDPLSPFAVGGEDLDPFGCQRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL