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PRXL2A

Gene
PRXL2A
Protein
Peroxiredoxin-like 2A
Organism
Homo sapiens
Length
229 amino acids
Function
Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
Similarity
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Mass
25.764 kDa
Sequence
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHIRTEVKDFQPYFKGEIFLDEKKKFYGPQRRKMMFMGFIRLGVWYNFFRAWNGGFSGNLEGEGFILGGVFVVGSGKQGILLEHREKEFGDKVNLLSVLEAAKMIKPQTLASEKK

Gene
Prxl2a
Protein
Peroxiredoxin-like 2A
Organism
Rattus norvegicus
Length
229 amino acids
Function
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.
Similarity
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Mass
25.763 kDa
Sequence
MSFLQDSSFFSMGMWSIGVGAFGAAALALLLANTDMFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVVKEKVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMLMGLVRLGVWYNSFRAWKGGFSGNFEGEGFILGGVFVIGSGKQGVLLEHREKEFGDRVNLLSVLEAVKKIKPQTPASRQS

Gene
prxl2a
Protein
Peroxiredoxin-like 2A
Organism
Xenopus laevis
Length
227 amino acids
Function
Involved in redox regulation of the cell. Acts as an antioxidant (By similarity).
Similarity
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Mass
25.221 kDa
Sequence
MFDLSDQLITMGLWSISIGAFGAAVAGILLANTDFFLSQTEKATLDYLEETELKTIGEEPRLFKAKDLWERDGAVIMAVRRPGCFLCREEASGLSTLKPQLDQLGVPLYAIVKENIGNEVEHFQPYFNGKVFLDAKGQFYGPQKRKMMLLGLVRLGVWQNFRRAWKGGFEGNLEGEGLILGGMFVIGSGKQGILLEHREKEFGDKANLTAVLDAARKISKQTAQNDN

Gene
prxl2a
Protein
Peroxiredoxin-like 2A
Organism
Xenopus tropicalis
Length
227 amino acids
Function
Involved in redox regulation of the cell. Acts as an antioxidant (By similarity).
Similarity
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Mass
25.23 kDa
Sequence
MFDLSDQLIAMGLWSISIGAFGAAVAGILLANTDLFLTQTEEATLDYLEETELKAIGDEPKSFKAKDLWEKNGAVVMAVRRPGCFLCREEASDLSSLKSQLDQLGVPLYAVVKENIGNEVEQFQPYFNGKIFLDEKGKFYGPQKRKMMFLGLVRLGVWQNFRRAWKGGFEGNLEGEGLILGGMFVIGSGKQGILLEHREKEFGDKANLTAVLDAARKINKQRAQNDN

Gene
PRXL2A
Protein
Peroxiredoxin-like 2A
Organism
Gallus gallus
Length
224 amino acids
Function
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass (By similarity).
Similarity
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Mass
24.948 kDa
Sequence
MSFLPDFGIFTMGMWSVGLGAVGAAITGIVLANTDLFLSKPEKATLEFLEAIELKTLGSEPRTFKASELWKKNGAVIMAVRRPGUFLCREEASELSSLKPQLSKLGVPLYAVVKEKIGTEVEDFQHYFQGEIFLDEKRSFYGPRKRKMMLSGFFRIGVWQNFFRAWKNGYSGNLEGEGFTLGGVYVIGAGRQGILLEHREKEFGDKVSLPSVLEAAEKIKPQAS

Gene
PRXL2A
Protein
Peroxiredoxin-like 2A
Organism
Bos taurus
Length
218 amino acids
Function
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.
Similarity
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Mass
24.355 kDa
Sequence
MGMWSIGAGAIGVAALALLLANTDMFLAKPEKAALEYLEDIDLKTLEKDAVTFKAKALWEKNGAVIMAVRRPGCFLCREEATDLSSLKPKLDELGVPLYAVVKEHIKNEVKDFQPYFKGEIFLDENKKFYGPQRRKMMFMGFVRLGVWQNFFRAWNGGFSGNLDGEGFILGGVFVMGPGKQGILLEHREKEFGDKVNLTSVLEAARKIRPQTSASEKQ

Gene
Prxl2a
Protein
Peroxiredoxin-like 2A
Organism
Mus musculus
Length
218 amino acids
Function
Involved in redox regulation of the cell (By similarity). Acts as an antioxidant (By similarity). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity). May affect bone resorption and help to maintain bone mass (By similarity). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
Similarity
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Mass
24.395 kDa
Sequence
MGMWSIGVGAVGAAAVALLLANTDMFLSKPRKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVVKEQVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMFMGLIRLGVWYNSFRAWNGGFSGNLEGEGFILGGVFVIGSGKQGILLEHREKEFGDRVNPLSVLEAVKKIKLQTPASGRS

Gene
prxl2a
Protein
Peroxiredoxin-like 2A
Organism
Danio rerio
Length
212 amino acids
Function
Involved in redox regulation of the cell. Acts as an antioxidant (By similarity).
Similarity
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Mass
23.043 kDa
Sequence
MGMWSLGLGAVGAAIAGLILANTDFLLTKSAPATVDYLANADLKTIDGDERSLKAKALWEKSGAVIMAVRRPGUFLCREEASELSSLKPQLDELGVPLYAVVKENVGTEIQDFRPHFAGEIFLDEKQAFYGPQQRKMGGLGFIRLGVWQNFVRAWRAGYQGNMNGEGFILGGVFVMGSGGQGVLLEHREKEFGDKVSLESVLEAAKKVVVEK