Protein
Probable histone-arginine methyltransferase 1.3
Organism
Arabidopsis thaliana
Function
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability (By similarity). Recruited to promoters upon gene activation, methylates histone H3 and activates transcription via chromatin remodeling (PubMed:27676073). Positive regulator in the oxidative stress tolerance that promotes the expression of enzymes preventing oxidative stress such as APX1 and GPX1 by histone methylation (H3R17me2a). Confers tolerance to cadmium CdCl(2) and salt NaCl stresses (PubMed:27676073).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Sequence
MEVSSVKKLEQLEYSLESVTDLSSSSVSSSSPAVATFSYVDGVTELRFLQSDSTHCFNFDLASAQLFKLGPVHFICVSDGSSSSEEKSFSKGVNIKFKNEKDSKDFCESFEEWRNDSVVQGSSLQNGTVSANKSKFDNKIEASSAKMYFHYYGQLLHQQNMLQDYVRTGTYYAAVMENHSDFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMAEYARKLIAGNPLFADRITVIKGKVEDIELPEKADILISEPMGTLLVNERMLESYVIARDRFMTPKGKMFPTVGRIHMAPFSDEFLFIEMANKAMFWQQQNYYGVDLTPLYGSAHQGYFSQPVVDAFDPRLLVASPMFHMIDFTQMKEEDFYEIDIPLKFTASMCTRMHGLACWFDVLFDGSTVQRWLTTAPGAPTTHWYQIRCVLSQPIYVMAGQEITGRLHLIAHSAQSYTIDLTLSAKMWGPGASQGGILQSSTCKFDLKEPYYRMSQPQAYPVAQEPPLQPQPELSTQQDIQTPNDELEEELLQQLPQNPSAQL