Protein
Actin-regulating kinase PRK1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Function
Protein kinase involved in regulation of actin cytoskeleton organization and endocytosis. Phosphorylates the endocytic protein SLA1. The CDC28-CLN3 complex phosphorylation of SLA1 enhances its further phosphorylation by PRK1, weakening SLA1 association with PAN1, an activator of the actin-nucleating ARP2/3 complex. Plays a role in cell wall regulation and required for oxidative stress survival.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Sequence
MPQPPPNAYKAGTRLTVGSHKVSIIKYISEGGFAHVYTCTIDPPFQGSTVACLKRVVVPSKWQLSLLRQEVDAMRRLRGNKHIVSYIDSHASRLGDSNTSGTNHSQQQQYEVFLLMEYCENNGLIDFMNTRLVNKLTEKEIIDIMYQVTIGVAMCHHLRPPLIHRDIKIENVLIDGKGVFKLCDFGSSVNYLPPPRNPQELQLMKDDLMQHTTPQYRAPEMIDLSKGFPIDDKSDIWALGIFLYKLCYYTTPFERPNQSSLQELEHTILNCSETLRFSDQPGSIFSPRLKNAIKVCLRADPRRRPNAVQLLGEIAAMKGEKTIPNVVPYSVIEQQRTKQASALEEDTKKGQASFVETKKITSKPKTDPFANIDKSKFLNKSGYKLSSVTAESRTVPARPLSAFFDDGNTPRIYSQGNRSTPSVQDYVKEELAKGESYEFNEPDGTLEFLKSREEEKLNQRNDTGGSFKAAFKNGLRKISTGGNISANNTGSSVKSNRRASLKRIITGGSNHNRKHSEENTKNVEDSNPVSSAPKKLSIQHRMQQLLNQNDHQRVQKSAQGYGKYTDIKASEDIDEINKPTLSKHSQKKLSPPAVPVNLSSQRNKSQQSSSTTKKYPIKDSKPLSKVRNNPPKDSVKTKPPPPKPKKPVYLKSPTKLEIADQRRLSDASEISMPDLDDLEKQFSKRFPSYV