PREP2

Presequence protease 2, chloroplastic/mitochondrial

1080 amino acids

ATP-independent protease that degrades both mitochondrial and chloroplastic transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.

Belongs to the peptidase M16 family. PreP subfamily.

121.131 kDa

MLRSLTCSSTITSTSLFFRSFRQLPRSYLSPSSSTTVVGASGRNIRRLSTLEAAGRRLFLRRGLKLLSAASRGLNGQFSRLSIRAVATQSAPSSYPGQDEAEKLGFEKVSEEFISECKSKAVLFKHKKTGCEVMSVSNDDENKVFGIVFRTPPKDSTGIPHILEHSVLCGSRKYPMKEPFVELLKGSLHTFLNAFTYPDRTCYPVASTNKKDFYNLVDVYLDAVFFPKCVDDVHTFQQEGWHYELNDPSEDISYKGVVFNEMKGVYSQPDNILGRVTQQALCPENTYGVDSGGDPKDIPKLTFEKFKEFHRQYYHPSNARIWFYGDDDPVHRLRVLSEYLDMFDASPARDSSKVEPQKLFSRPRRIVEKYPAGEDGDLKKKHMVCLNWLLSDKPLDLQTQLALGFLDHLMLGTPASPLRKILLESGLGEALVNSGMEDELLQPQFSIGLKGVSDDNVQKVEELVMNTLRKLADEGFDTDAVEASMNTIEFSLRENNTGSSPRGLSLMLQSIAKWIYDMDPFEPLKYEEPLKSLKARIAEKGSKSVFSPLIEEYILNNPHCVTIEMQPDPEKASLEEAEEKSILEKVKASMTEEDLTELARATEELRLKQETPDPPDALKCVPSLNLSDIPKEPIYVPTEVGDINGVKVLRNDLFTNNILYTEVVFDMGSVKHELLQLIPLFCQSLLEMGTQDLTFVQLNQLIGRKTGGISVYPLTSSVYGRDDPCSKIIVRGKSMVGRAEDLFNLMNCVLQEVRFTDQQRFKQFVSQSRARMENRLRGSGQGIAAARMDAMLNVAGWMSEQMGGLSYLEFLHTLEQKVDQDWEGISSSLEEIRRSFLSRNGCIVNMTADGKSLTNTEKYVGKFLDLLPENPSGELVTWDARLPLRNEAIVIPTQVNYVGKAGNIYSSGYKLDGSSYVISKHISNTWLWDRVRVSGGAYGGSCDFDSHSGVFSFLSYRDPNLLKTLDIYDGTGDFLRGLDVDEDTLTKAIIGTIGDVDSYQLPDAKGYTSLLRHLLNVTDEERQIRREEILSTSLKDFKEFAEAIDSVSDKGVAVAVASQEDIDAANRERSNFFEVKKAAL