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PPBP

Gene
PPBP
Protein
Platelet basic protein
Organism
Homo sapiens
Length
128 amino acids
Function
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
13.894 kDa
Sequence
MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD

Gene
PPBP
Protein
Platelet basic protein
Organism
Sus scrofa
Length
119 amino acids
Function
Chemoattractant factor for neutrophils.
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
12.615 kDa
Sequence
MSLRLGAISSCTTSSPFPVLQVLLPLSLLLTTLVPATMGAAKIEGRMAHVELRCLCLNTVSGIHPSNIQSLEVIRAGAHCAKVEVIATLKNDKKICLDPEAPRIKKIVQKIMEDGGSAA